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Licensed Unlicensed Requires Authentication Published by De Gruyter November 22, 2016

CYP2D6 variability in populations from Venezuela

  • Nancy Moreno EMAIL logo , Carlos Flores-Angulo , Cecilia Villegas and Yuselin Mora

Abstract

CYP2D6 is an important cytochrome P450 enzyme that plays an important role in the metabolism of about 25% of currently prescribed drugs. The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatments. The most prevalent diseases in the admixed population from Venezuela are cardiovascular and cancer, whereas viral, bacterial and parasitic diseases, particularly malaria, are prevalent in Amerindian populations; in the treatment of these diseases, several drugs that are metabolized by CYP2D6 are used. In this work, we reviewed the data on CYP2D6 variability and predicted metabolizer phenotypes, in healthy volunteers of two admixed and five Amerindian populations from Venezuela. The Venezuelan population is very heterogeneous as a result of the genetic admixture of three major ethnical components: Europeans, Africans and Amerindians. There are noticeable inter-regional and inter-population differences in the process of mixing of this population. Hitherto, there are few published studies in Venezuela on CYP2D6; therefore, it is necessary to increase research in this regard, in particular to develop studies with a larger sample size. There is a considerable amount of work remaining before CYP2D6 is integrated into clinical practice in Venezuela.

Acknowledgments

We are grateful to Dr. Flor Herrera from Instituto de Investigaciones Biomédicas “Dr. Francisco J. Triana Alonso” for useful suggestions. I would like to thank Prof. Willie Peterson for revising the English in the manuscript.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved the submission.

  2. Research funding: This study was financed by Fondo Nacional de Ciencia y Tecnología (FONACIT) through of the project N° 2012001248.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-7-23
Accepted: 2016-11-2
Published Online: 2016-11-22
Published in Print: 2016-12-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

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