The objective of this study was to evaluate the occurrence of drug-drug interactions (DDIs) in patients on cancer chemotherapy, with the identification of risk factors for these DDIs.
This was a cross-sectional, descriptive study carried out at the Department of Onco-Radiation at Guru Gobind Singh Medical College, Faridkot, Punjab. The DDIs were recorded with the help of a drug interaction/interplay information software.
In total, 354 interactions were identified from 283 patient records. The mean age of the patients in the study was 49.05±14.35 years. According to the mechanism of interaction, 306 (86.44%) drug interactions were classified as pharmacokinetic and 48 (13.56%) as pharmacodynamic in nature.
Sensitization of the treating oncologist and the establishment of alerts, such as electronic alerts or a novel fully digital computerized technology that gives a warning when a health expert enters a patient’s prescription orders into the electronic medical documentation, can be helpful in controlling DDIs.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
3. Kohler GI, Bode-Boger SM, Busse R, Hoopmann M, Welte T, Boger RH. Drug-drug interactions in medical patients: effects of in hospital treatment and relation to multiple drug use. Int J Clin Pharmacol Ther 2000;38:504–13.10.5414/CPP38504Search in Google Scholar PubMed
4. Goldberg RM, Mabee J, Chan L, Wong S. Drug-drug and drug-disease interactions in the ED: analysis of a high-risk population. Am J Emerg Med 2001;14:447–50.10.1016/S0735-6757(96)90147-3Search in Google Scholar
6. Wolters Kluwer Health. Drug Interaction Facts. Version 4.0. 2006. Available at: http://www.factsandcomparisons.com. Accessed 28 Nov 2015. (Lexi-Interact™, Hudson, Ohio: LexiComp Inc.; April 29, 2012).Search in Google Scholar
8. Dirin MM, Mousavi S, Afshari AR, Tabrizian K, Ashrafi MH. Potential drug-drug interactions in prescriptions dispensed in community and hospital pharmacies in east of Iran. J Res Pharm Pract 2014;3:104–7.10.4103/2279-042X.141118Search in Google Scholar PubMed PubMed Central
9. Geneva: World Health Organization. World Health Organization. Technical Report Series No. 498. International drug monitoring: the role of national centers. 1972. Available at: www.who-umc.org/graphics/9277.pdf. Accessed: 30 June 2016.Search in Google Scholar
10. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239–45.10.1038/clpt.1981.154Search in Google Scholar PubMed
12. Bjerrum L, Andersen M, Petersen G, Kragstrup J. Exposure to potential drug interactions in primary health care. Scand J Prim Health Care 2003;21:153–8.10.1080/02813430310001806Search in Google Scholar PubMed
13. Riechelmann RP, Tannock IF, Wang L, Saad ED, Taback NA, Krzyzanowska MK. Potential drug interactions and duplicate prescriptions among cancer patients. J Natl Cancer Inst 2007;99:592–80.10.1093/jnci/djk130Search in Google Scholar PubMed
14. Scientific Advisory Board of the Arizona Center for Education and Research on Therapeutics. QT drug lists. Available at: http://www.arizonacert.org. Accessed 16 February 2016.Search in Google Scholar
15. Lafforgue P, Monjanel-Mouterde S, Durand A, Catalin J, Acquaviva PC. Is there an interaction between low doses of corticosteroids and methotrexate in patients with rheumatoid arthritis? A pharmacokinetic study in 33 patients. J Rheumatol 1993;20:263–67.Search in Google Scholar PubMed
16. Johnson EJ, MacGowana AP, Potterb MN, Stockley RJ, White LO, Slade RR. Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy. J Antimicrob Chemother 1990;25:837–42.10.1093/jac/25.5.837Search in Google Scholar PubMed
18. Tracy TS, Jones DR, Hall SD, Brater DC, Bradley JD, Krohn K. The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis. Eur J Clin Pharmacol 1992;42:121–25.10.1007/BF00278469Search in Google Scholar PubMed
20. Sokol KC, Knudsen JF, Li MM. Polypharmacy in older oncology patients and the need for an interdisciplinary approach to side-effect management. J Clin Pharm Ther 2007;32:169–75.10.1111/j.1365-2710.2007.00815.xSearch in Google Scholar PubMed
22. van Leeuwen RW, Swart EL, Boven E, Boom FA, Schuitenmaker MG, Hugtenburg JG. Potential drug interactions in cancer therapy: a prevalence study using an advanced screening method. Ann Oncol 2011;22:2334–41.10.1093/annonc/mdq761Search in Google Scholar PubMed
24. Andersson ML, Bottiger Y, Lindh JD, Wettermark B, Eiermann B. Impact of the drug-drug interaction database sfinx on prevalence of potentially serious drug-drug interactions in primary health care. Eur J Clin Pharmacol 2012;69:565–71.10.1007/s00228-012-1338-ySearch in Google Scholar PubMed
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