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Publicly Available Published by De Gruyter July 2, 2021

An overview of mental health during the COVID-19 pandemic

  • Patrick J. Chen , Yanna Pusica , Dorsa Sohaei , Ioannis Prassas EMAIL logo and Eleftherios P. Diamandis ORCID logo EMAIL logo
From the journal Diagnosis


Since its initial outbreak in late 2019, the COVID-19 pandemic has profoundly affected the global community. In addition to the negative health consequences of contracting COVID-19, the implementation of strict quarantine and lockdown measures has also disrupted social networks and devastated the global economy. As a result, there is rising concern that the pandemic has taken a toll on the mental health of the general population. To better understand its impact, an increasing number of studies examined the effects of the pandemic on mental health and psychosocial implications of enforced quarantine and lockdown. In this article, we aim to review and summarize the findings from a variety of studies that have explored the psychosociological effects of the pandemic and its impact on the mental well-being of the general population. We will also examine how various demographic groups, such as the elderly and youth, can be more susceptible or resilient to the pandemic’s mental health effects. We hope to provide a broader understanding of the underlying causes of mental health issues triggered by the pandemic and provide recommendations that may be employed to address mental health issues in the population over the long-term.


Following its initial outbreak, the Coronavirus Disease 2019 (COVID-19) spread rapidly across the global community, prompting the World Health Organization(WHO) to declare COVID-19 a global pandemic in March 2020 [1]. Several countries quickly implemented strict containment measures such as social distancing, school and commercial closures, and home quarantine to reduce the transmission rates within their communities. While these health measures have effectively combated the spread of COVID-19 [2, 3], there is concern of the magnification and incoming amplification of mental health issues.

The pandemic has had a profound effect on the mental health of the population due to the disruptions in the social [4], economic [5], and mental fabric of the global community [6], [7], [8]. There has been an increased prevalence of depression and anxiety disorders, suicide risk, post-traumatic stress symptoms (PTSS), and insomnia among the population. While this is driven, in part, by the fear of contracting or spreading the illness to loved ones [9, 10], the psychological effects of quarantine have also contributed to increases in feelings of depression, anxiety, insomnia, and feelings of social disconnect [1114]. Meanwhile, public and commercial closures have significantly disrupted the education and career plans of the young generation [15], [16], [17], and growing levels of unemployment and financial debt have also contributed to increased anxiety and depression [18].

The detrimental effects on mental health resulting from the prolonged exposure to the stress imposed by the pandemic are not equally shared among the population [19]. Among the vulnerable groups are the elderly [20], particularly those in institutionalized care, the recently unemployed [21], young children and adolescents [22]. Essential workers and health care providers may be particularly vulnerable to mental health difficulties due to a greater risk of disease exposure to themselves and family members, work intensification and shortages of personal protective equipment [23, 24]. Moreover, survivors of COVID-19 are susceptible to developing mental health issues due to the discrimination and stigma associated with infection [25]. Groups that are more vulnerable to the social, economic and physical impacts of COVID-19 such as racialized individuals, immigrants and refugees, indigenous communities, and low-wage workers are likely, in turn, more vulnerable to mental health effects as well [26], [27], [28], [29].

As the COVID-19 pandemic and lockdowns continue, there has been an increase of interest in the long-term mental health consequences. This article aims to summarize the current literature for factors that contribute to mental distress in isolation, anxiety and depression, suicide risk, PTSS, and sleeping disorders. To provide a broader understanding of the current landscape of the population’s mental well-being during the COVID-19 pandemic, we also consider the mental health of vulnerable groups such as the elderly, children, and adolescents. Figure 1 summarizes challenges and proposed solutions related to the COVID-19 pandemic, which are further discussed below in some detail.

Figure 1: 
Challenges people are facing during COVID-19 lockdowns and proposed solutions.
The Figure summarizes key challenges mentioned and possible solutions suggested in the paper. Fonts and sizes are randomized and do not correlate to any data. The illustration is a synopsis of points that are further elaborated upon in the paper. PTSS, post traumatic stress symptoms; AI, artificial intelligence.
Figure 1:

Challenges people are facing during COVID-19 lockdowns and proposed solutions.

The Figure summarizes key challenges mentioned and possible solutions suggested in the paper. Fonts and sizes are randomized and do not correlate to any data. The illustration is a synopsis of points that are further elaborated upon in the paper. PTSS, post traumatic stress symptoms; AI, artificial intelligence.

Social isolation and loneliness

Social isolation and its impact on mental health is perhaps the most challenging aspect many individuals have faced this past year, notwithstanding those dealing with the virus directly. Although imposed lockdown policies have effectively curbed the spread of infection, social isolation instigated by quarantine has caused an increase of negative emotions and psychological effects, including confusion, anger, anxiety, and depression among the general populace [7, 8, 12, 30]. In a study conducted by The Angus Reid Institute (a Canadian national not-for-profit research foundation), 50% of Canadians have reported that their mental health has worsened during the first lockdown [31]. Another 42% reported that their physical health has diminished due to inactivity (Figure 2) [31]. Further, prolonged exposure to loneliness is a decisive risk factor for post-traumatic stress disorder symptoms (PTSS) and is associated with the development of minor psychiatric disorders and an increase in suicide risk [32, 33].

Figure 2: 
Mental health and physical well-being since COVID 19 shutdown.
The Figure contains data by the Angus Reid Institute from their online survey conducted from April 15–17, 2020, among a representative randomized sample of 1,912 Canadian adults. The estimated margin of error is about 2%.are due to rounding.
Figure 2:

Mental health and physical well-being since COVID 19 shutdown.

The Figure contains data by the Angus Reid Institute from their online survey conducted from April 15–17, 2020, among a representative randomized sample of 1,912 Canadian adults. The estimated margin of error is about 2%.are due to rounding.

Loneliness among the elderly has also sharply increased as a result of the lockdown [34]. The elderly are extremely vulnerable to the effects of loneliness as their social circles typically decline with age. Further, with the isolation orders preventing participation at places of worship, community centers, and daycare venues, compounded with fears of abandonment and neglect, there has been an increase in the prevalence of social disconnectedness, anxiety, and depression among the elderly [9, 35, 36]. Additionally, isolation of the elderly puts them at a greater risk of neurocognitive decline [37], autoimmune and cardiovascular disease [38], as well as decreases in sleep quality and increases in sleep disturbances [39].

The negative consequences of loneliness are not restricted to the elderly. They can affect youth and adults, noted by a 5.5% increase in the perception of loneliness among middle-aged adults in the UK [40]. In Canada, 20–25% of Canadians aged 18 to 54 have increased the amount of alcohol they drink due to distancing measures, and sales of cannabis have reportedly increased [41, 42]. Further, as youths are at a period of social and cognitive transition, the lockdown can significantly hinder the development of their social skills and identity, which can translate into immediate and long-term consequences [43]. Further, youths have a higher risk of developing mental health symptoms such as anxiety and depression in the long-term, compared to adults, as their ability to cope with distressing situations and emotions may not be fully developed [16].

Anxiety and depression

The fear of contracting and spread COVID-19 has caused a great deal of mental distress among the general populace [44]. It has caused an increase in the prevalence of stress, anxiety disorders, and depression [45]. Distress and anxiety disorders, driven by concerns and self-awareness of their health, were exceptionally high among individuals who had access to higher education [46]. The use of social media has also shown to increase anxiety due to confusion brought on by the large volume and frequent circulation of disinformation, false reports about COVID-19, and high frequency of unpleasant news [47]. High levels of anxiety in the population were also driven by the lockdown, which had caused economic decline [48], and disruptions to educational and professional development [15, 16]. The measures taken to shut down most sectors of the economy during the spread of COVID-19 have resulted in sudden and unforeseen mass unemployment. This has predominantly affected poor and non-democratic nations because of the absence of countervailing economic measures. This issue is also wildly prevalent in Canada and should not be dismissed because the complexity of implementing massive subsides will leave many people vulnerable to poverty and its mental health consequences, such as anxiety and depression. In a study conducted by Nanos Research, 38.9% of Canadians responded that personal financial hardship/debt concerns them most about the personal impact the current COVID-19 outbreak has on their lives [49], which can be seen as a contributing factor to the stress many Canadians are feeling (Figure 3).

Figure 3: 
Feeling of stress before COVID-19 and during April 2020.
(A) Before COVID-19 pie-chart contains individual’s answers to the following question: “Thinking of the months before the Covid-19 outbreak, did you feel stress never, almost never, occasionally, regularly or all the time?” (B) during April 2020 pie-chart contains individual’s answers to the following question: “In the last month because of the Covid-19 outbreak have you felt stress never, almost never, occasionally, regularly or all the time?” the Figure was derived by mental health Commission of Canada and Nanos from their RDD dual hybrid telephone and online random survey conducted from April 25–27, 2020, among a representative randomized sample of 1,049 Canadian adults. The estimated margin of error of ± 3.1 percentage points.
Figure 3:

Feeling of stress before COVID-19 and during April 2020.

(A) Before COVID-19 pie-chart contains individual’s answers to the following question: “Thinking of the months before the Covid-19 outbreak, did you feel stress never, almost never, occasionally, regularly or all the time?” (B) during April 2020 pie-chart contains individual’s answers to the following question: “In the last month because of the Covid-19 outbreak have you felt stress never, almost never, occasionally, regularly or all the time?” the Figure was derived by mental health Commission of Canada and Nanos from their RDD dual hybrid telephone and online random survey conducted from April 25–27, 2020, among a representative randomized sample of 1,049 Canadian adults. The estimated margin of error of ± 3.1 percentage points.

Depression and anxiety were also greatly increased among the elderly due to the pandemic [50, 51]. While the uncertainty and fears of contracting and spreading COVID-19 have primarily driven feelings of anxiety, social isolation has further exacerbated the pandemic’s mental sequelae [34]. Feelings of neglect can also arise among individuals who do not have access to the assistance necessary to maintain their health and care [52]. Deficiencies in maintaining standards in their hygienic and dietary habits can also contribute significantly to depression and anxiety [50]. Among the elderly who are dependent on the assistance of family, friends, or neighbors, there has also been an increase in feelings of being a burden and a sense of worthlessness, which leads to frustration, depression, and anxiety [36, 53].

While children and adolescents are unlikely to experience a severe COVID-19 infection [54], a combination of stay-at-home orders and an increasingly stressful life at home can negatively influence their social, cognitive, and emotional development [5557]. Children from low socioeconomic backgrounds are especially vulnerable to domestic violence and child maltreatment [56, 58, 59]. School closures have also driven increases in feelings of anxiety (22–25%) and depression (17–20%) due to pressures to maintain academic success during the transition to online schooling [60, 61].

Suicide risk

As the pandemic continues to spread and restrictive lockdown measures remain in place, there have been growing concerns that the chronic anxiety and stress caused directly by the pandemic, coupled with the social and economic difficulties that have arisen, may increase suicide risk and self-harm among the population [48, 62, 63]. While evidence from the previous SARS epidemic found an increase in suicide risk following the outbreak [64], less can be stated with confidence from current longitudinal studies, as the pandemic was a repetitively recent phenomenon.

Several factors can contribute to increased suicide risk among the population. It has been suggested that survivors of COVID-19 are at increased suicide risk due to the psychological trauma from the fear of spreading the disease, thanatophobia, and the stigmatization that follows infection with COVID-19 [63, 65]. Trauma may be more pronounced among patients with severe COVID-19 infections, as individuals who required admission to the ICU were at higher risk of developing post-traumatic stress disorder and post-traumatic stress symptoms [66, 67]. Additionally, lockdowns to control the spread of COVID-19 have also introduced a high degree of economic instability and greatly increased the unemployment rate worldwide [18]. As economic difficulties have previously been shown to contribute to suicide risk [62], suicide rates have been projected to increase following the COVID-19 pandemic [68, 69].

Evidence from the 2003 SARS epidemic suggests that suicide risk is higher among the elderly, especially among women, and individuals who were dependent on caregivers to maintain a reasonable standard of living [70, 71]. In the context of the COVID-19 pandemic, older individuals who feel that they lack social cohesion, or have been prevented from participating in social gatherings due to lockdown, are more vulnerable to suicide as they feel more disconnected from society [36, 53]. Suicide risk among the elderly is further exacerbated by feelings of being devalued or perceived as a burden, such as when the elderly were passed over in priority for treatment when medical resources were in short supply [72].While suicide rates among children and adolescents in the general population have not largely been influenced by the COVID-19 pandemic thus far [73], stay-at-home mandates can still negatively influence youth’s mental health, which could translate to increased suicide risk later in life. In particular, as families are forced to stay home throughout the pandemic, there has been an increase in domestic violence and child maltreatment [56, 58, 74]. The increased stress levels among parents and the in-home scenario produced by the pandemic can exacerbate the aggression and abuse towards children. While vulnerable youth would often rely on support systems such as childcare and school staff, it becomes much harder to do so with quarantine and stay at home orders [75]. Adverse childhood experiences, such as domestic violence, sexual abuse, and neglect, are strong contributors to suicide risk. Especially at risk are populations of physically or mentally impaired youth, identify as part of the LGBT community, or have a history of abusing illicit substances. Youths from these demographic groups that have been isolated at home could also see an increase in self-harm [76].

Post-traumatic stress symptoms

Similar to the SARS outbreak [70, 77], contracting COVID-19 can lead to post-illness post-traumatic stress disorder (PTSD) and can manifest several symptoms such as insomnia, depression, and anxiety [66, 78, 79]. Studies have shown that post-traumatic stress symptoms (PTSS) can persist for prolonged periods of up to and beyond 30 months [80], and in part, are driven by anxiety and fear of being discriminated against and stigmatized [78]. As such, mental care should be considered for COVID-19 survivors. Aside from the direct effects of COVID-19 infection, the pandemic has exposed populations to prolonged periods of fear [81], as well as emotional and behavioral changes due to lockdown and physical distancing. Among the general populace, people from lower educational backgrounds and families with lower socioeconomic status were more likely to use negative coping strategies leading to the development of PTSS [82, 83]. In particular, there was a higher prevalence of PTSD/PTSS sub-symptoms, such as negative alternations in cognition, mood, and poorer quality of sleep patterns, which were more prevalent in females than males [84].

Sleep disorders

In addition to the pandemic lockdown’s adverse psychological and mental effects, its immediate effects had also caused reductions in the quality and quantity of sleep in the broader population [85], [86], [87]. These disruptions in the general populace’s sleeping patterns in lockdown have mainly been driven by the drastic changes in daily schedule and patterns, which has delayed regular bedtime [85], caused an increase in difficulty to fall asleep, and increased the frequency of sleep disturbances [88, 89]. Increased sedentary lifestyles, decreased exposure to natural light, decreases in social interaction, boredom, as well as increased screen time and consumption of social media also contribute to disruptions in natural sleep times and cause sleep disturbances [90].

Psychological factors have also contributed dramatically to sleep disturbances and patterns. In particular, high levels of anxiety, depression, loneliness, and uncertainty are strong predictors for the presence of insomnia and poor sleep quality [87, 91]. This was also demonstrated in a Greek population where cases of insomnia and poorer sleep quality significantly increased in prevalence shortly after the COVID-19 outbreak [92]. Further, disadvantaged individuals, such as those who experienced the economic consequences of the lockdown or expressed concern regarding their education or career, are more likely to suffer from sleep disturbances and poorer sleep quality [86].

Interestingly, while the psychologically burdened subpopulations are likely to experience decreases in sleep quality, some studies have suggested that the lockdown has not greatly affected the prevalence of sleep disorders [93] and suggests that the disruptions from the social routine allow for more time available and flexibility for individual sleep adaptation [94], leading to improvement of sleep quality during the lockdown [95]. Further, work from home orders may confer time savings due to a loss of commuting time, which can translate to more sleep time and allows for sleep and work schedules to become more closely aligned with the natural circadian rhythm [89]. However, these findings do not extend to populations with elevated symptoms of anxiety, depression, and loneliness.

Steps forward

Mandated quarantine orders have led to a dramatic change in lifestyle behaviors and increased mental health issues such as feelings of loneliness and social disconnect. To better safeguard mental health during the pandemic, several steps can be taken, such as implementing digital technology for social activities, mental health checks, and telemedicine [8, 96]. Through video calls, activities can be coordinated similarly to that of virtual workplaces and can help mitigate feelings of social disconnect. This can greatly reduce the rates of depression, loneliness, and suicide risk among the general population, especially with individuals who live alone or suffer from mental illness. The use of video calls and telemedicine also allow access to health care and effectively combat feelings of loneliness and abandonment, especially among the elderly population.

With the increase in technology use, it is natural that social media usage would increase during the pandemic [97]. However, social media has been linked to increased anxiety and poor mental health [97, 98] due to frequent unfavorable news and large volumes of disinformation. Therefore, limiting the use of social media may prove beneficial to the general population’s mental health. Lockdowns have also driven a significant increase in boredom, screen time, and greatly decreased physical activity, which can negatively affect mental and physical health [99]. As previously mentioned, these factors can also contribute significantly to the development of poor sleep quality and sleeping patterns [87, 90, 91]. Developing a routine, especially one that includes regular physical exercise at home, as well as some exposure to natural light, could greatly improve sleeping patterns and decrease feelings of frustration driven by boredom. Further, developing schedules can significantly limit screen time among youth and greatly improve sleep quality [100].

The management of depression, suicide risk, and feelings of neglect within the vulnerable subpopulations, such as the elderly and youths, is a major concern. Among the older population, there has been increasing concern of elder abuse and neglect within long-term care homes [101, 102], highlighted by the concentrated numbers of COVID-19 related cases and mortalities among the residents. This underscores the necessity for stricter enforcement of health guidelines and the development of stringent policies that mandate a consistent and adequate standard of care. The mental well-being of the elderly and their families can be greatly improved by ameliorating the hygiene, attention, and quality of life in long-term care homes. Further, there are growing concerns of child maltreatment [58, 59] and an increase in suicide risk among marginalized youth communities [76]. Providing adequate social support, particularly in poor socioeconomic standing areas, as well as providing appropriate intervention for violent domestic cases may potentially mitigate risks of isolation and suicide risk within youth populations [102], [103], [104].

Long term predictions

There is still a great deal of uncertainty of the future, and as the pandemic drags on, customs and socialization will need to continue to change in order to fulfill the eusocial nature of society. While we have previously discussed steps that can be taken to alleviate some of the pandemic’s mental strain [105], these recommendations alone are insufficient to ameliorate and mental sequelae of isolation from vulnerable and isolated populations, such as the elderly, in the long term.

To better cope with the feelings of loneliness, there was an increase in pet adoptions, as humans looked for comfort from animal companions. While this option effectively combats loneliness and provides the benefit of long-term companionship, several demographic groups are limited in this option, given the cost of time, economic and physical responsibilities necessary to maintain a pet. As an alternative, we predict and recommend the rapid development of robotic and artificial intelligence (AI)-based companionship. We have seen that COVID-19 has resulted in a rapid shift to Zoom, Facebook, Teams, Mural, and other nonspecific platforms to bring people together, facilitate the exchange of ideas, and retain teamwork among colleagues. However, most existing tools are still underdeveloped, even though cloud computing has expanded in the last six years to support greater storage and access to data that many applications and services use, allowing remote workers to access corporate resources and continue working However, with the new communication style and remote work, businesses will face new threats and security will most likely move past the traditional firewall parameters and with this progress, new onboarding evaluations will develop with AI technology. Given the current progress and improvements on interactive AI design in their ability to interpret and respond to increasingly complex speech, verbal and nonverbal cues, AI also shows a promising avenue to counter the effects of loneliness during the quarantine.

The practicality of developing and utilizing AI and digital services is best highlighted through its current deployment throughout the manufacturing, medical research, and entertainment industries. While automatons and interactive AI are still relatively simple, previous studies on social assistive robots have shown that they can confer benefits to mental health, such as improve people’s moods, ameliorating depression, as well as encouraging social interaction and connectedness [106]. Further, due to the increase in demand for reliable and accessible public health, there has been a growing interest in developing interactive chatbots [107] and potentially robots, to assist with self-managing conditions.

As it currently stands, there have been no large-scale longitudinal studies examining the mental health benefits of interactive AI, current studies are limited in scope, and there remains the outstanding question of whether the use of technology is sufficient to replace human interaction. Regardless, there is ample evidence supporting the notion that humanoid robots can provide some social comfort and promote social connectivity as a whole. As such, we are optimistic regarding its development, and we advocate for the widespread use of interactive robots for vulnerable and neglected populations to combat loneliness in the future.


This article aimed to review and summarize findings regarding the mental health effects of the COVID-19 pandemic and lockdown orders. Here, we highlighted the prevalence and underlying causes of anxiety, depression, suicide risk, PTSS, and sleep disorders during the COVID-19 pandemic. We have also offered suggestions that may help monitor and ameliorate mental health issues during the pandemic and lockdown. While there has been a great deal of research on the current state of mental health, the pandemic′s long-term effects on the general population are not yet apparent as this has been a recent phenomenon. However, using previous experiences from past epidemics, such as SARS, MERS, and H1N1, and the COVID-19 pandemic, we can better equip ourselves to manage the future mental health crises that may arise.

Corresponding author: Ioannis Prassas, PhD, Mount Sinai Hospital, Joseph & Wolf Lebovic Ctr., Flr 6 - Rm L6-201 Toronto, ON, M5T 3L9 Toronto, ON, Canada; and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada Phone: +416 586 8443; Fax: +416 619 5521, E-mail: ; and Eleftherios P. Diamandis, PhD, MD, Mount Sinai Hospital, Joseph & Wolf Lebovic Ctr., Flr 6 - Rm L6-201 Toronto, ON, M5T 3L9 Toronto, ON, Canada; Department of Clinical Biochemistry, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada; and Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada, Phone: +416 586 8443; Fax: +416 619 5521, E-mail:
Patrick J. Chen and Yanna Pusica contributed equally to this work.
  1. Research funding: None declared.

  2. Author contribution: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Dr. Eleftherios P. Diamandis declares that he holds an advisory/consultant role with Abbott Diagnostics. All other authors have nothing to declare.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.


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Received: 2021-03-27
Accepted: 2021-05-26
Published Online: 2021-07-02
Published in Print: 2021-11-25

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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