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Licensed Unlicensed Requires Authentication Published by De Gruyter November 26, 2016

Benzyldimethyl[3-(miristoylamino)-propyl]ammonium chloride stabilized silver nanoparticles (Argumistin™) in medicine: results of clinical trials for treatment of infectious diseases of dogs and perspectives for humans

  • Yurii Krutyakov

    Yurii Krutyakov, MS, PhD, is Head of the Laboratory of Functional Nanomaterials for Agriculture, Department of Chemistry, Lomonosov Moscow State University (MSU). He graduated from the MSU in 2005 and obtained his PhD degree in Colloid and Interface Science in 2008. His research interests lie in the area of design and creation of new plant protection products and fertilizers containing nanomaterials as active components, development of nanosilver based antibacterial and anti-inflammatory veterinary drugs against infectious diseases of agricultural and small animals.

    , Alexey Klimov

    Alexey Klimov is a member of the development team of an antiseptic drug with a wound healing effect for animals and a crop protection agent widely used in Russia. He graduated from the Moscow State University in 2011. He is the author of several publications on the topic of colloidal chemistry and physics. He has participated in conferances on colloidal and physical chemistry and quantum optics.

    , Boris Violin

    Boris Violin, PhD graduated from the Moscow Veterinary Academy in 1978. His professional field includes quality assurance and standardization of pharmaceutical drugs. His research interests lie in the area of veterinary pharmacology and toxicology and the development of new pharmaceutical formulations, primarily, drugs for animal infectious diseases treatment. Has over 180 publications on the topic of veterinary pharmacology and toxicology.

    , Vladimir Kuzmin

    Vladimir Kuzmin graduated from the Leningrad Veterinary Institute in 1976. He obtained his doctoral degree in Veterinary Science in 1995. His research interests are broad and cover planning of preventive and curative measures for different animal diseases; epizootic monitoring; studying of novel pharmaceutical drugs for animal treatment, etc. he is the author of over 170 publications and holds five patents.

    , Victoria Ryzhikh

    Victoria Ryzhikh has a in Membrane Technology. She is a senior researcher and international certification manager of Grand Harvest Research International Development Ltd. Her research interests include physical chemistry of polymers, membrane technology and nanotechnology and nanomaterials. She is the author of several publications on the physical chemistry of polymers.

    , Alexander Gusev

    Alexander Gusev, PhD is the director of the Research Institution for Ecology and Biotechnology, Derzhavin’s Tambov State University, Tambov, Russia; he is assistant Professor in NUST “MISiS”, Moscow, Russia. His research interests include nanobiointeractions and nanotoxicology of carbon, metallic and oxide nanoparticles. He has published over 30 peer reviewed articles, over 50 conference proceedings, textbooks, and holds two patents.

    , Olga Zakharova

    Olga Zakharova is a specialist in environmental science, she is Deputy Director of Research Institution for Ecology and Biotechnology, Derzhavin’s Tambov State University, Tambov, Russia. Her research interests lie in the field of antibacterial nanomaterials and recycling of nanodispersed wastes. She has published 13 peer reviewed articles, over 20 conference proceedings, textbooks, and holds one patent.

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    and George Lisichkin

    George Lisichkin is Head of the Laboratory of Surface Chemistry, Department of Chemistry, Moscow State University (MSU). He graduated from the MSU in 1964. He obtained his doctoral degree in Chemical Science in 1982. His research interests include surface chemistry, heterogenic catalysis, chemistry of marine environment and problems in chemical education. He is the author of over 300 publications and over 70 inventions.

Abstract

Increased interest in nanosilver during the last 10 years is mainly explained by the emergence and spread of pathogenic microorganisms with multiple drug resistance, including resistance to last-generation antibiotics. In this article, we for the first time, give a description of large-scale clinical trials of a new nanosilver based antibacterial drug [containing two active components: silver nanoparticles (AgNPs) (10–50 ppm) and benzyldimethyl[3-(miristoylamino)-propyl]ammonium chloride (100 ppm)] registered in Russia in 2015 as a veterinary drug under the brand name Argumistin™. This drug has been approved for application in a diluted dosage form – as eye drops, intranasal drops and orally; it has also been approved for application in a more concentrated dosage form (up to 50 ppm of nanosilver) as ear drops and as an antiseptic during demodicosis and gum disease treatment, open wound treatment, etc. We have registered the high therapeutic effectiveness of Argumistin™ during treatment of infectious conjunctivitis, gingivitis, parodontosis and enteritis of dogs. Application of this antibacterial drug gives considerable (up to 70% in case of periodontal diseases) reduction in the treatment period and prevention of complications. The results of clinical trials in the treatment of infectious diseases of dogs makes Argumistin™ a promising candidate for an effective antibacterial drug for human medicine.

About the authors

Yurii Krutyakov

Yurii Krutyakov, MS, PhD, is Head of the Laboratory of Functional Nanomaterials for Agriculture, Department of Chemistry, Lomonosov Moscow State University (MSU). He graduated from the MSU in 2005 and obtained his PhD degree in Colloid and Interface Science in 2008. His research interests lie in the area of design and creation of new plant protection products and fertilizers containing nanomaterials as active components, development of nanosilver based antibacterial and anti-inflammatory veterinary drugs against infectious diseases of agricultural and small animals.

Alexey Klimov

Alexey Klimov is a member of the development team of an antiseptic drug with a wound healing effect for animals and a crop protection agent widely used in Russia. He graduated from the Moscow State University in 2011. He is the author of several publications on the topic of colloidal chemistry and physics. He has participated in conferances on colloidal and physical chemistry and quantum optics.

Boris Violin

Boris Violin, PhD graduated from the Moscow Veterinary Academy in 1978. His professional field includes quality assurance and standardization of pharmaceutical drugs. His research interests lie in the area of veterinary pharmacology and toxicology and the development of new pharmaceutical formulations, primarily, drugs for animal infectious diseases treatment. Has over 180 publications on the topic of veterinary pharmacology and toxicology.

Vladimir Kuzmin

Vladimir Kuzmin graduated from the Leningrad Veterinary Institute in 1976. He obtained his doctoral degree in Veterinary Science in 1995. His research interests are broad and cover planning of preventive and curative measures for different animal diseases; epizootic monitoring; studying of novel pharmaceutical drugs for animal treatment, etc. he is the author of over 170 publications and holds five patents.

Victoria Ryzhikh

Victoria Ryzhikh has a in Membrane Technology. She is a senior researcher and international certification manager of Grand Harvest Research International Development Ltd. Her research interests include physical chemistry of polymers, membrane technology and nanotechnology and nanomaterials. She is the author of several publications on the physical chemistry of polymers.

Alexander Gusev

Alexander Gusev, PhD is the director of the Research Institution for Ecology and Biotechnology, Derzhavin’s Tambov State University, Tambov, Russia; he is assistant Professor in NUST “MISiS”, Moscow, Russia. His research interests include nanobiointeractions and nanotoxicology of carbon, metallic and oxide nanoparticles. He has published over 30 peer reviewed articles, over 50 conference proceedings, textbooks, and holds two patents.

Olga Zakharova

Olga Zakharova is a specialist in environmental science, she is Deputy Director of Research Institution for Ecology and Biotechnology, Derzhavin’s Tambov State University, Tambov, Russia. Her research interests lie in the field of antibacterial nanomaterials and recycling of nanodispersed wastes. She has published 13 peer reviewed articles, over 20 conference proceedings, textbooks, and holds one patent.

George Lisichkin

George Lisichkin is Head of the Laboratory of Surface Chemistry, Department of Chemistry, Moscow State University (MSU). He graduated from the MSU in 1964. He obtained his doctoral degree in Chemical Science in 1982. His research interests include surface chemistry, heterogenic catalysis, chemistry of marine environment and problems in chemical education. He is the author of over 300 publications and over 70 inventions.

Acknowledgments

This article was not supported by grants.

  1. Conflict of interest statement: Authors state no conflict of interest. All authors have read the journal’s Publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.

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Received: 2016-6-27
Accepted: 2016-10-18
Published Online: 2016-11-26
Published in Print: 2016-10-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

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