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Publicly Available Published by De Gruyter August 31, 2013

Porous polymeric scaffolds for bone regeneration

  • Katarzyna Filipczak , Ireneusz Janik , Marek Kozicki , Piotr Ulanski EMAIL logo , Janusz M. Rosiak , Leonardo A. Pajewski EMAIL logo , Radoslaw Olkowski , Piotr Wozniak , Anna Chroscicka and Malgorzata Lewandowska-Szumiel EMAIL logo
From the journal e-Polymers


Solvent casting/particulate leaching has been used to synthesize highly porous polymeric scaffolds of controlled pore size, based on poly(methyl methacrylate) (PMMA) and poly(ε-caprolactone) (PCL). Obtained structures have a total porosity of c. 60%, with good interconnections between the pores. Porous scaffolds prepared using the greatest size of NaCl particles have the best mechanical properties. Both PMMA- and PCL-based materials can be sterilized by ionizing radiation. In the case of PCL-based scaffolds, irradiation causes cross-linking of polymer chains, which leads to an improvement of the mechanical properties of the scaffold. The compressive elastic modulus for non-porous samples increases with irradiation dose from 1.5 MPa for 0 kGy to 1.9 MPa for 280 kGy. Preliminary in vitro studies indicate good biocompatibility of both materials.

Published Online: 2013-8-31
Published in Print: 2005-12-1

© 2013 by Walter de Gruyter GmbH & Co.

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