Detrimental and protective fat: body fat distribution and its relation to metabolic disease

References

1. Sanada H, Yokokawa H, Yoneda M, Yatabe J, Sasaki Yatabe M, Williams SM, Felder RA, Jose PA. High body mass index is an important risk factor for the development of type 2 diabetes. Intern Med 2012;51:1821–6.10.2169/internalmedicine.51.7410Search in Google Scholar PubMed PubMed Central

2. Brown CD, Higgins M, Donato KA, Rohde FC, Garrison R, Obarzanek E, Ernst ND, Horan M. Body mass index and the prevalence of hypertension and dyslipidemia. Obes Res 2000;8:605–19.10.1038/oby.2000.79Search in Google Scholar PubMed

3. Miyake T, Kumagi T, Hirooka M, Furukawa S, Koizumi M, Tokumoto Y, Ueda T, Yamamoto S, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M. Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community-based retrospective longitudinal cohort study. J Gastroenterol 2013;48:413–22.10.1007/s00535-012-0650-8Search in Google Scholar PubMed

4. Lamon-Fava S, Wilson PW, Schaefer EJ. Impact of body mass index on coronary heart disease risk factors in men and women. The Framingham Offspring Study. Arterioscler Thromb Vasc Biol 1996;16:1509–15.10.1161/01.ATV.16.12.1509Search in Google Scholar

5. Haffner SM. Relationship of metabolic risk factors and development of cardiovascular disease and diabetes. Obesity (Silver Spring) 2006;14:121S–7S.10.1038/oby.2006.291Search in Google Scholar PubMed

6. Anjana M, Sandeep S, Deepa R, Vimaleswaran KS, Farooq S, Mohan V. Visceral and central abdominal fat and anthropometry in relation to diabetes in Asian Indians. Diabetes Care 2004;27:2948–53.10.2337/diacare.27.12.2948Search in Google Scholar PubMed

7. Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE, Fujimoto WY. Visceral adiposity and the risk of impaired glucose tolerance: a prospective study among Japanese Americans. Diabetes Care 2003;26:650–5.10.2337/diacare.26.3.650Search in Google Scholar PubMed

8. Wei M, Gaskill SP, Haffner SM, Stern MP. Waist circumference as the best predictor of noninsulin dependent diabetes mellitus (NIDDM) compared to body mass index, waist/hip ratio and other anthropometric measurements in Mexican Americans—a 7-year prospective study. Obes Res 1997;5:16–23.10.1002/j.1550-8528.1997.tb00278.xSearch in Google Scholar PubMed

9. Dowse GK, Zimmet PZ, Gareeboo H, George K, Alberti MM, Tuomilehto J, Finch CF, Chitson P, Tulsidas H. Abdominal obesity and physical inactivity as risk factors for NIDDM and impaired glucose tolerance in Indian, Creole, and Chinese Mauritians. Diabetes Care 1991;14:271–82.10.2337/diacare.14.4.271Search in Google Scholar PubMed

10. Araneta MR, Barrett-Connor E. Ethnic differences in visceral adipose tissue and type 2 diabetes: filipino, African-American, and white women. Obes Res 2005;13:1458–65.10.1038/oby.2005.176Search in Google Scholar PubMed

11. Mamo JC, Watts GF, Barrett PH, Smith D, James AP, Pal S. Postprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression? Am J Physiol Endocrinol Metab 2001;281:E626–32.10.1152/ajpendo.2001.281.3.E626Search in Google Scholar PubMed

12. Chan DC, Barrett HP, Watts GF. Dyslipidemia in visceral obesity: mechanisms, implications, and therapy. Am J Cardiovasc Drugs 2004;4:227–46.10.2165/00129784-200404040-00004Search in Google Scholar PubMed

13. Zambon A, Marchiori M, Manzato E. Dyslipidemia in visceral obesity: pathophysiological mechanisms, clinical implications and therapy. G Ital Cardiol (Rome) 2008;9:29S–39S.Search in Google Scholar

14. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006;113:898–918.10.1161/CIRCULATIONAHA.106.171016Search in Google Scholar PubMed

15. Kim SK, Kim HJ, Hur KY, Choi SH, Ahn CW, Lim SK, Kim KR, Lee HC, Huh KB, Cha BS. Visceral fat thickness measured by ultrasonography can estimate not only visceral obesity but also risks of cardiovascular and metabolic diseases. Am J Clin Nutr 2004;79:593–9.10.1093/ajcn/79.4.593Search in Google Scholar PubMed

16. Matsuzawa Y, Nakamura T, Shimomura I, Kotani K. Visceral fat accumulation and cardiovascular disease. Obes Res 1995;3:645S–7S.10.1002/j.1550-8528.1995.tb00481.xSearch in Google Scholar PubMed

17. Speliotes EK, Massaro JM, Hoffmann U, Vasan RS, Meigs JB, Sahani DV, Hirschhorn JN, O’Donnell CJ, Fox CS. Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study. Hepatology 2010;51:1979–87.10.1002/hep.23593Search in Google Scholar PubMed PubMed Central

18. Despres JP, Lemieux S, Lamarche B, Prud’homme D, Moorjani S, Brun LD, Gagne C, Lupien PJ. The insulin resistance-dyslipidemic syndrome: contribution of visceral obesity and therapeutic implications. Int J Obes Relat Metab Disord 1995;19:S76–86.Search in Google Scholar

19. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS, Murabito JM, Meigs JB, Cupples LA, D’Agostino RB, Sr., O’Donnell CJ. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 2007;116:39–48.10.1161/CIRCULATIONAHA.106.675355Search in Google Scholar PubMed

20. Porter SA, Massaro JM, Hoffmann U, Vasan RS, O’Donnel CJ, Fox CS. Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care 2009;32:1068–75.10.2337/dc08-2280Search in Google Scholar PubMed PubMed Central

21. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Grundy SM. Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 1995;96:88–98.10.1172/JCI118083Search in Google Scholar PubMed PubMed Central

22. Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 1997;46:1579–85.10.2337/diacare.46.10.1579Search in Google Scholar PubMed

23. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Adams-Huet B, Grundy SM. Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes 1996;45:1684–93.10.2337/diab.45.12.1684Search in Google Scholar PubMed

24. Ferreira I, Henry RM, Twisk JW, van Mechelen W, Kemper HC, Stehouwer CD, Amsterdam GS. Health Longitudinal. The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: the Amsterdam Growth and Health Longitudinal Study. Arch Intern Med 2005;165:875–82.10.1001/archinte.165.8.875Search in Google Scholar PubMed

25. Wildman RP, Janssen I, Khan UI, Thurston R, Barinas-Mitchell E, El Khoudary SR, Everson-Rose SA, Kazlauskaite R, Matthews KA, Sutton-Tyrrell K. Subcutaneous adipose tissue in relation to subclinical atherosclerosis and cardiometabolic risk factors in midlife women. Am J Clin Nutr 2011;93:719–26.10.3945/ajcn.110.007153Search in Google Scholar PubMed PubMed Central

26. Snijder MB, Visser M, Dekker JM, Goodpaster BH, Harris TB, Kritchevsky SB, De Rekeneire N, Kanaya AM, Newman AB, Tylavsky FA, Seidell JC, A. B. C. S. Health. Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study. Diabetologia 2005;48:301–8.10.1007/s00125-004-1637-7Search in Google Scholar PubMed

27. McLaughlin T, Lamendola C, Liu A, Abbasi F. Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity. J Clin Endocrinol Metab 2011;96:E1756–60.10.1210/jc.2011-0615Search in Google Scholar PubMed PubMed Central

28. Koster A, Stenholm S, Alley DE, Kim LJ, Simonsick EM, Kanaya AM, Visser M, Houston DK, Nicklas BJ, Tylavsky FA, Satterfield S, Goodpaster BH, Ferrucci L, Harris TB, Health AB. Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (Silver Spring) 2010;18:2354–61.10.1038/oby.2010.86Search in Google Scholar PubMed PubMed Central

29. Gallagher D, Kelley DE, Yim JE, Spence N, Albu J, Boxt L, Pi-Sunyer FX, Heshka S, M. R. I. A. S. G. o. t. L. A. R. Group, Adipose tissue distribution is different in type 2 diabetes. Am J Clin Nutr 2009;89:807–14.10.3945/ajcn.2008.26955Search in Google Scholar PubMed PubMed Central

30. Yim JE, Heshka S, Albu JB, Heymsfield S, Gallagher D. Femoral-gluteal subcutaneous and intermuscular adipose tissues have independent and opposing relationships with CVD risk. J Appl Physiol 2008;104:700–7.10.1152/japplphysiol.01035.2007Search in Google Scholar PubMed PubMed Central

31. Manolopoulos KN, Karpe F, Frayn KN. Gluteofemoral body fat as a determinant of metabolic health. Int J Obes (Lond) 2010;34:949–59.10.1038/ijo.2009.286Search in Google Scholar PubMed

32. Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R. Waist circumference and cardiometabolic risk: a consensus statement from shaping America’s health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Diabetes Care 2007;30:1647–52.10.2337/dc07-9921Search in Google Scholar PubMed

33. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996;271:665–8.10.1126/science.271.5249.665Search in Google Scholar PubMed

34. Bergman RN. Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein? Diabetologia 2000;43:946–52.10.1007/s001250051474Search in Google Scholar PubMed

35. Williamson JR, Kreisberg RA, Felts PW. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci USA 1966;56:247–54.10.1073/pnas.56.1.247Search in Google Scholar PubMed PubMed Central

36. Nemecz M, Preininger K, Englisch R, Furnsinn C, Schneider B, Waldhausl W, Roden M. Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 1999;29:166–72.10.1002/hep.510290110Search in Google Scholar PubMed

37. Borba-Murad GR, Mario EG, Bassoli BK, Bazotte RB, de Souza HM. Comparative acute effects of leptin and insulin on gluconeogenesis and ketogenesis in perfused rat liver. Cell Biochem Funct 2005;23:405–13.10.1002/cbf.1163Search in Google Scholar PubMed

38. Bassil MS, Mrayati MM, Hwalla NC, Obeid OA. Acute effect of leptin and ghrelin injection on postprandial glycogen and lipid synthesis in rats. Ann Nutr Metab 2007;51:14–21.10.1159/000100816Search in Google Scholar PubMed

39. Gerner RR, Wieser V, Moschen AR, Tilg H. Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver. Can J Physiol Pharmacol 2013;91:867–72.10.1139/cjpp-2013-0050Search in Google Scholar PubMed

40. Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 2010;52:774–88.10.1002/hep.23719Search in Google Scholar PubMed

41. Topping DL, Mayes PA. Insulin and non-esterified fatty acids. Acute regulators of lipogenesis in perfused rat liver. Biochem J 1982;204:433–9.10.1042/bj2040433Search in Google Scholar PubMed PubMed Central

42. Bjorntorp P. “Portal” adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 1990;10:493–6.10.1161/01.ATV.10.4.493Search in Google Scholar

43. Williamson JR. Mechanism for the stimulation in vivo of hepatic gluconeogenesis by glucagon. Biochem J 1966;101:11C–4C.10.1042/bj1010011CSearch in Google Scholar

44. Clarke SD, Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance. Br J Nutr 2000;83:Suppl 1:S59–66.10.1017/S0007114500000969Search in Google Scholar PubMed

45. Xu J, Nakamura MT, Cho HP, Clarke SD. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem 1999;274:23577–83.10.1074/jbc.274.33.23577Search in Google Scholar PubMed

46. Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 1997;46:1768–74.10.2337/diab.46.11.1768Search in Google Scholar PubMed

47. Svedberg J, Bjorntorp P, Smith U, Lonnroth P. Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. Diabetes 1990;39:570–4.10.2337/diab.39.5.570Search in Google Scholar PubMed

48. Dobbins RL, Szczepaniak LS, Bentley B, Esser V, Myhill J, McGarry JD. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes 2001;50:123–30.10.2337/diabetes.50.1.123Search in Google Scholar PubMed

49. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997;46:3–10.10.2337/diab.46.1.3Search in Google Scholar

50. Heilbronn L, Smith SR, Ravussin E. Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Int J Obes Relat Metab Disord 2004;28:Suppl 4:S12–21.10.1038/sj.ijo.0802853Search in Google Scholar PubMed

51. Voshol PJ, Rensen PC, van Dijk KW, Romijn JA, Havekes LM. Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models. Biochim Biophys Acta 2009;1791:479–85.10.1016/j.bbalip.2008.12.015Search in Google Scholar PubMed

52. Nielsen S, Guo Z, Johnson CM, Hensrud DD, Jensen MD. Splanchnic lipolysis in human obesity. J Clin Invest 2004;113:1582–8.10.1172/JCI21047Search in Google Scholar PubMed PubMed Central

53. Guo Z, Hensrud DD, Johnson CM, Jensen MD. Regional postprandial fatty acid metabolism in different obesity phenotypes. Diabetes 1999;48:1586–92.10.2337/diabetes.48.8.1586Search in Google Scholar PubMed

54. Roust LR, Jensen MD. Postprandial free fatty acid kinetics are abnormal in upper body obesity. Diabetes 1993;42:1567–73.10.2337/diab.42.11.1567Search in Google Scholar PubMed

55. Jensen MD, Haymond MW, Rizza RA, Cryer PE, Miles JM. Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 1989;83:1168–73.10.1172/JCI113997Search in Google Scholar PubMed PubMed Central

56. Fernandez-Veledo S, Nieto-Vazquez I, Vila-Bedmar R, Garcia-Guerra L, Alonso-Chamorro M, Lorenzo M. Molecular mechanisms involved in obesity-associated insulin resistance: therapeutical approach. Arch Physiol Biochem 2009;115: 227–39.10.1080/13813450903164330Search in Google Scholar PubMed

57. Magkos F, Fabbrini E, Patterson BW, Eagon JC, Klein S. Portal vein and systemic adiponectin concentrations are closely linked with hepatic glucose and lipoprotein kinetics in extremely obese subjects. Metabolism 2011;60:1641–8.10.1016/j.metabol.2011.03.019Search in Google Scholar PubMed PubMed Central

58. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007;56:1010–3.10.2337/db06-1656Search in Google Scholar PubMed

59. Weigert J, Neumeier M, Wanninger J, Filarsky M, Bauer S, Wiest R, Farkas S, Scherer MN, Schaffler A, Aslanidis C, Scholmerich J, Buechler C. Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. Clin Endocrinol (Oxf) 2010;72:342–8.10.1111/j.1365-2265.2009.03664.xSearch in Google Scholar PubMed

60. Karbaschian Z, Hosseinzadeh-Attar MJ, Giahi L, Golpaie A, Masoudkabir F, Talebpour M, Kosari F, Karbaschian N, Hoseini M, Mazaherioun M. Portal and systemic levels of visfatin in morbidly obese subjects undergoing bariatric surgery. Endocrine 2013;44:114–8.10.1007/s12020-012-9821-xSearch in Google Scholar PubMed

61. Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R, CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009;15:914–20.10.1038/nm.1964Search in Google Scholar PubMed

62. Satoor SN, Puranik AS, Kumar S, Williams MD, Ghale M, Rahalkar A, Karandikar MS, Shouche Y, Patole M, Bhonde R, Yajnik CS, Hardikar AA. Location, location, location: beneficial effects of autologous fat transplantation. Sci Rep 2011;1:81.10.1038/srep00081Search in Google Scholar PubMed PubMed Central

63. Dolinkova M, Dostalova I, Lacinova Z, Michalsky D, Haluzikova D, Mraz M, Kasalicky M, Haluzik M. The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Mol Cell Endocrinol 2008;291:63–70.10.1016/j.mce.2008.05.001Search in Google Scholar PubMed

64. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998;394:897–901.10.1038/29795Search in Google Scholar PubMed

65. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996;93:14564–8.10.1073/pnas.93.25.14564Search in Google Scholar PubMed PubMed Central

66. Iikuni N, Lam QL, Lu L, Matarese G, La Cava A. Leptin and Inflammation. Curr Immunol Rev 2008;4:70–9.10.2174/157339508784325046Search in Google Scholar PubMed PubMed Central

67. Martin-Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000;199:15–24.10.1006/cimm.1999.1594Search in Google Scholar PubMed

68. Van Harmelen V, Reynisdottir S, Eriksson P, Thorne A, Hoffstedt J, Lonnqvist F, Arner P. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998;47:913–7.10.2337/diabetes.47.6.913Search in Google Scholar PubMed

69. Linder K, Arner P, Flores-Morales A, Tollet-Egnell P, Norstedt G. Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women. J Lipid Res 2004;45:148–54.10.1194/jlr.M300256-JLR200Search in Google Scholar PubMed

70. Li FP, He J, Li ZZ, Luo ZF, Yan L, Li Y. Effects of resistin expression on glucose metabolism and hepatic insulin resistance. Endocrine 2009;35:243–51.10.1007/s12020-009-9148-4Search in Google Scholar PubMed

71. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature 2001;409:307–12.10.1038/35053000Search in Google Scholar PubMed

72. Rajala MW, Qi Y, Patel HR, Takahashi N, Banerjee R, Pajvani UB, Sinha MK, Gingerich RL, Scherer PE, Ahima RS. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes 2004;53:1671–9.10.2337/diabetes.53.7.1671Search in Google Scholar PubMed

73. Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C, Macphee CH, Smith SA. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun 2003;300:472–6.10.1016/S0006-291X(02)02841-3Search in Google Scholar

74. Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV, O’Rahilly S. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 2001;50:2199–202.10.2337/diabetes.50.10.2199Search in Google Scholar

75. Nagaev I, Smith U. Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun 2001;285:561–4.10.1006/bbrc.2001.5173Search in Google Scholar

76. Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, Patsch JR. Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem Biophys Res Commun 2003;309:286–90.10.1016/j.bbrc.2003.07.003Search in Google Scholar

77. Silswal N, Singh AK, Aruna B, Mukhopadhyay S, Ghosh S, Ehtesham NZ. Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem Biophys Res Commun 2005;334:1092–101.10.1016/j.bbrc.2005.06.202Search in Google Scholar

78. Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol 2005;174:5789–95.10.4049/jimmunol.174.9.5789Search in Google Scholar

79. Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R. Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res 2002;10:1095–103.10.1038/oby.2002.149Search in Google Scholar

80. Fain JN, Cheema PS, Bahouth SW, Lloyd Hiler M. Resistin release by human adipose tissue explants in primary culture. Biochem Biophys Res Commun 2003;300:674–8.10.1016/S0006-291X(02)02864-4Search in Google Scholar

81. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288–9510.1038/nm788Search in Google Scholar PubMed

82. Kwon H, Pessin JE. Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne) 2013;4:71.10.3389/fendo.2013.00071Search in Google Scholar PubMed PubMed Central

83. Degawa-Yamauchi M, Moss KA, Bovenkerk JE, Shankar SS, Morrison CL, Lelliott CJ, Vidal-Puig A, Jones R, Considine RV. Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor alpha. Obes Res 2005;13:662–9.10.1038/oby.2005.74Search in Google Scholar PubMed

84. Kovacova Z, Tencerova M, Roussel B, Wedellova Z, Rossmeislova L, Langin D, Polak J, Stich V. The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue. Int J Obes (Lond) 2012;36:1360–5.10.1038/ijo.2011.223Search in Google Scholar PubMed

85. Shaker OG, Sadik NA. Vaspin gene in rat adipose tissue: relation to obesity-induced insulin resistance. Mol Cell Biochem 2013;373:229–39.10.1007/s11010-012-1494-5Search in Google Scholar PubMed

86. Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H. Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Diabetes 2012;61: 2823–32.10.2337/db12-0232Search in Google Scholar PubMed PubMed Central

87. Auguet T, Quintero Y, Riesco D, Morancho B, Terra X, Crescenti A, Broch M, Aguilar C, Olona M, Porras JA, Hernandez M, Sabench F, del Castillo D, Richart C. New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC Med Genet 2011;12:60.10.1186/1471-2350-12-60Search in Google Scholar PubMed PubMed Central

88. de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC. Omentin plasma levels and gene expression are decreased in obesity. Diabetes 2007;56:1655–61.10.2337/db06-1506Search in Google Scholar PubMed

89. Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 2007;282:28175–88.10.1074/jbc.M700793200Search in Google Scholar PubMed

90. Alfadda AA, Sallam RM, Chishti MA, Moustafa AS, Fatma S, Alomaim WS, Al-Naami MY, Bassas AF, Chrousos GP, Jo H. Differential patterns of serum concentration and adipose tissue expression of chemerin in obesity: adipose depot specificity and gender dimorphism. Mol Cells 2012;33:591–6.10.1007/s10059-012-0012-7Search in Google Scholar PubMed PubMed Central

91. Yang RY, Havel PJ, Liu FT. Galectin-12: a protein associated with lipid droplets that regulates lipid metabolism and energy balance. Adipocyte 2012;1:96–100.10.4161/adip.19465Search in Google Scholar PubMed PubMed Central

92. Rhodes DH, Pini M, Castellanos KJ, Montero-Melendez T, Cooper D, Perretti M, Fantuzzi G. Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function. Obesity (Silver Spring) 2013;21:310–9.10.1002/oby.20016Search in Google Scholar PubMed PubMed Central

93. Wisse BE. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol: JASN 2004;15:2792–800.10.1097/01.ASN.0000141966.69934.21Search in Google Scholar PubMed

94. Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev 2013;93:1–21.10.1152/physrev.00017.2012Search in Google Scholar PubMed

95. Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y, Tanti J-F. Interleukin-1β-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 2007;148:241–51.10.1210/en.2006-0692Search in Google Scholar PubMed PubMed Central

96. Koenen TB, Stienstra R, van Tits LJ, Joosten LA, van Velzen JF, Hijmans A, Pol JA, van der Vliet JA, Netea MG, Tack CJ, Stalenhoef AF, de Graaf J. The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue. Endocrinology 2011;152:3769–78.10.1210/en.2010-1480Search in Google Scholar PubMed

97. Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, van den Berg SA, Rensen PC, Voshol PJ, Fantuzzi G, Hijmans A, Kersten S, Müller M, van den Berg WB, van Rooijen N, Wabitsch M, Kullberg B-J, van der Meer JW, Kanneganti T, Tack CJ, Netea MG. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 2010;12:593–605.10.1016/j.cmet.2010.11.011Search in Google Scholar PubMed PubMed Central

98. Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009;27:519–50.10.1146/annurev.immunol.021908.132612Search in Google Scholar PubMed

99. Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O’Mahony L, Palomares O, Rhyner C, Quaked N, Schaffartzik A, Van De Veen W, Zeller S, Zimmermann M, Akdis CA. Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases. J Allergy Clin Immunol 2011;127:701–21.e770.10.1016/j.jaci.2010.11.050Search in Google Scholar PubMed

100. Boraschi D, Dinarello CA. IL-18 in autoimmunity: review. Eur Cytokine Netw 2006;17:224–52.Search in Google Scholar

101. Mirza MS. Obesity, visceral fat, and NAFLD: querying the role of adipokines in the progression of nonalcoholic fatty liver disease. ISRN Gastroenterology2011;2011:11.10.5402/2011/592404Search in Google Scholar PubMed PubMed Central

102. Dobrian AD, Lieb DC, Ma Q, Lindsay JW, Cole BK, Ma K, Chakrabarti SK, Kuhn NS, Wohlgemuth SD, Fontana M, Nadler JL. Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. Biochem Biophys Res Commun 2010;403:485–90.10.1016/j.bbrc.2010.11.065Search in Google Scholar PubMed PubMed Central

103. Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, Yamashita S, Miura M, Fukuda Y, Takemura K, Tokunaga K, Matsuzawa Y. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996;2:800–3.10.1038/nm0796-800Search in Google Scholar PubMed

104. Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, Vernon AH, Libby P. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res 2008;103:467–76.10.1161/CIRCRESAHA.108.177105Search in Google Scholar

105. Bruun JM, Lihn AS, Pedersen SB, Richelsen B. Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocr Metab 2005;90:2282–9.10.1210/jc.2004-1696Search in Google Scholar

106. Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K-I, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006;116:1494–505.10.1172/JCI26498Search in Google Scholar

107. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548–56.10.1210/jc.2004-0395Search in Google Scholar

108. Matsushima K, Morishita K, Yoshimura T, Lavu S, Kobayashi Y, Lew W, Appella E, Kung HF, Leonard EJ, Oppenheim JJ. Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med 1988;167:1883–93.10.1084/jem.167.6.1883Search in Google Scholar

109. Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 2001;14:705–14.10.1016/S1074-7613(01)00151-0Search in Google Scholar

110. Saksela O, Rifkin DB. Cell-associated plasminogen activation: regulation and physiological functions. Annu Rev Cell Biol 1988;4:93–126.10.1146/annurev.cb.04.110188.000521Search in Google Scholar PubMed

111. Mantovani RM, Rios DR, Moura LC, Oliveira JM, Carvalho FF, Cunha SB, Viana Mde F, Lamounier JA, Castro JC, Dusse LM, Simoes e Silva AC. Childhood obesity: evidence of an association between plasminogen activator inhibitor-1 levels and visceral adiposity. J Pediatr Endocrinol Metab: JPEM 2011;24:361–7.10.1515/jpem.2011.015Search in Google Scholar PubMed

112. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, Obin MS. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005;46:2347–55.10.1194/jlr.M500294-JLR200Search in Google Scholar PubMed

113. Willard-Mack CL. Normal structure, function, and histology of lymph nodes. Toxicol Pathol 2006;34:409–24.10.1080/01926230600867727Search in Google Scholar PubMed

114. Mebius RE. Lymphoid organs for peritoneal cavity immune response: milky spots. Immunity 2009;30:670–2.10.1016/j.immuni.2009.04.005Search in Google Scholar

115. Alagumuthu MB, Pattanayak SP, Rasananda M. The omentum: an organ of exceptional versatility. Ind J Surg 2006;136–41.Search in Google Scholar

116. Pond CM, Mattacks CA. In vivo evidence for the involvement of the adipose tissue surrounding lymph nodes in immune responses. Immunol Lett 1998;63:159–67.10.1016/S0165-2478(98)00074-1Search in Google Scholar

117. Mattacks CA, Sadler D, Pond CM. The cellular structure and lipid/protein composition of adipose tissue surrounding chronically stimulated lymph nodes in rats. J Anat 2003;202:551–61.10.1046/j.1469-7580.2003.00188.xSearch in Google Scholar

118. Ali AH, Koutsari C, Mundi M, Stegall MD, Heimbach JK, Taler SJ, Nygren J, Thorell A, Bogachus LD, Turcotte LP, Bernlohr D, Jensen MD. Free fatty acid storage in human visceral and subcutaneous adipose tissue: role of adipocyte proteins. Diabetes 2011;60:2300–7.10.2337/db11-0219Search in Google Scholar

119. Hellmer J, Marcus C, Sonnenfeld T, Arner P. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J Clin Endocrinol Metab 1992;75:15–20.Search in Google Scholar

120. Arner P, Hellstrom L, Wahrenberg H, Bronnegard M. Beta-adrenoceptor expression in human fat cells from different regions. J Clin Invest 1990;86:1595–600.10.1172/JCI114880Search in Google Scholar

121. Hoffstedt J, Arner P, Hellers G, Lonnqvist F. Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men. J Lipid Res 1997;38:795–804.10.1016/S0022-2275(20)37246-1Search in Google Scholar

122. Degerman E, Resjo S, Landstrom TR, Manganiello V. Methods to study phosphorylation and activation of the hormone-sensitive adipocyte phosphodiesterase type 3B in rat adipocytes. Methods Mol Biol 2001;155:167–80.Search in Google Scholar

123. Albu JB, Curi M, Shur M, Murphy L, Matthews DE, Pi-Sunyer FX. Systemic resistance to the antilipolytic effect of insulin in black and white women with visceral obesity. Am J Physiol 1999;277:E551–60.10.1152/ajpendo.1999.277.3.E551Search in Google Scholar PubMed

124. Bolinder J, Kager L, Ostman J, Arner P. Differences at the receptor and postreceptor levels between human omental and subcutaneous adipose tissue in the action of insulin on lipolysis. Diabetes 1983;32:117–23.10.2337/diab.32.2.117Search in Google Scholar PubMed

125. Zierath JR, Livingston JN, Thorne A, Bolinder J, Reynisdottir S, Lonnqvist F, Arner P. Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway. Diabetologia 1998;41:1343–54.10.1007/s001250051075Search in Google Scholar PubMed

126. Mittelman SD, Van Citters GW, Kirkman EL, Bergman RN. Extreme insulin resistance of the central adipose depot in vivo. Diabetes 2002;51:755–61.10.2337/diabetes.51.3.755Search in Google Scholar PubMed

127. Lefebvre AM, Laville M, Vega N, Riou JP, van Gaal L, Auwerx J, Vidal H. Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 1998;47: 98–103.10.2337/diab.47.1.98Search in Google Scholar PubMed

128. Ramis JM, Bibiloni B, Moreiro J, Garcia-Sanz JM, Salinas R, Proenza AM, Llado I. Tissue leptin and plasma insulin are associated with lipoprotein lipase activity in severely obese patients. J Nutr Biochem 2005;16:279–85.10.1016/j.jnutbio.2004.12.009Search in Google Scholar PubMed

129. Berndt J, Kovacs P, Ruschke K, Kloting N, Fasshauer M, Schon MR, Korner A, Stumvoll M, Bluher M. Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia 2007;50:1472–80.10.1007/s00125-007-0689-xSearch in Google Scholar PubMed

130. Berndt J, Kralisch S, Kloting N, Ruschke K, Kern M, Fasshauer M, Schon MR, Stumvoll M, Bluher M. Adipose triglyceride lipase gene expression in human visceral obesity. Exp Clin Endocrinol Diabetes 2008;116:203–10.10.1055/s-2007-993148Search in Google Scholar PubMed

131. Russo V, Yu C, Belliveau P, Hamilton A, Flynn LE. Comparison of human adipose-derived stem cells isolated from subcutaneous, omental, and intrathoracic adipose tissue depots for regenerative applications. Stem Cells Transl Med 2014;3:206–17.10.5966/sctm.2013-0125Search in Google Scholar PubMed PubMed Central

132. Djian P, Roncari AK, Hollenberg CH. Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture. J Clin Invest 1983;72:1200–8.10.1172/JCI111075Search in Google Scholar PubMed PubMed Central

133. Niesler CU, Siddle K, Prins JB. Human preadipocytes display a depot-specific susceptibility to apoptosis. Diabetes 1998;47:1365–8.10.2337/diab.47.8.1365Search in Google Scholar PubMed

134. Rosmond R, Bjorntorp P. Psychosocial and socio-economic factors in women and their relationship to obesity and regional body fat distribution. Int J Obes Relat Metab Disord 1999;23:138–45.10.1038/sj.ijo.0800782Search in Google Scholar PubMed

135. Speaker KJ, Fleshner M. Interleukin-1 beta: a potential link between stress and the development of visceral obesity. BMC Physiol 2012;12:8.10.1186/1472-6793-12-8Search in Google Scholar PubMed PubMed Central

136. Nov O, Shapiro H, Ovadia H, Tarnovscki T, Dvir I, Shemesh E, Kovsan J, Shelef I, Carmi Y, Voronov E, Apte RN, Lewis E, Haim Y, Konrad D, Bashan N, Rudich A. Interleukin-1beta regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability. PloS One 2013;8:e53626.10.1371/journal.pone.0053626Search in Google Scholar PubMed PubMed Central

137. Lagathu C, Yvan-Charvet L, Bastard JP, Maachi M, Quignard-Boulange A, Capeau J, Caron M. Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 2006;49:2162–73.10.1007/s00125-006-0335-zSearch in Google Scholar PubMed

138. Ranjit S, Boutet E, Gandhi P, Prot M, Tamori Y, Chawla A, Greenberg AS, Puri V, Czech MP. Regulation of fat specific protein 27 by isoproterenol and TNF-alpha to control lipolysis in murine adipocytes. J Lipid Res 2011;52:221–36.10.1194/jlr.M008771Search in Google Scholar PubMed PubMed Central

139. Tomlinson JW, Moore J, Cooper MS, Bujalska I, Shahmanesh M, Burt C, Strain A, Hewison M, Stewart PM. Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 2001;142:1982–9.10.1210/endo.142.5.8168Search in Google Scholar PubMed

140. Dunkelman SS, Fairhurst B, Plager J, Waterhouse C. Cortisol metabolism in obesity. J Clin Endocrinol Metab 1964;24: 832–41.10.1210/jcem-24-9-832Search in Google Scholar PubMed

141. Purnell JQ, Brandon DD, Isabelle LM, Loriaux DL, Samuels MH. Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women. J Clin Endocrinol Metab 2004;89:281–7.10.1210/jc.2003-030440Search in Google Scholar PubMed

142. Pasquali R, Cantobelli S, Casimirri F, Capelli M, Bortoluzzi L, Flamia R, Labate AM, Barbara L. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 1993;77:341–6.Search in Google Scholar

143. Duclos M, Corcuff JB, Etcheverry N, Rashedi M, Tabarin A, Roger P. Abdominal obesity increases overnight cortisol excretion. J Endocrinol Invest 1999;22:465–71.10.1007/BF03343591Search in Google Scholar PubMed

144. Mussig K, Remer T, Maser-Gluth C. Brief review: glucocorticoid excretion in obesity. J Steroid Biochem Mol Biol 2010;121: 589–93.10.1016/j.jsbmb.2010.01.008Search in Google Scholar PubMed

145. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001;294:2166–70.10.1126/science.1066285Search in Google Scholar PubMed

146. Mariniello B, Ronconi V, Rilli S, Bernante P, Boscaro M, Mantero F, Giacchetti G. Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing’s syndrome. Eur J Endocrinol 2006;155:435–41.10.1530/eje.1.02228Search in Google Scholar PubMed

147. Desbriere R, Vuaroqueaux V, Achard V, Boullu S-Ciocca, Labuhn M, Dutour A, Grino M. 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity (Silver Spring) 2006;14:794–8.10.1038/oby.2006.92Search in Google Scholar PubMed

148. Alfonso B, Araki T, Zumoff B. Is there visceral adipose tissue (VAT) intracellular hypercortisolism in human obesity? Horm Metab Res 2013;45:329–31.10.1055/s-0033-1337986Search in Google Scholar PubMed

149. Pereira CD, Azevedo I, Monteiro R, Martins MJ. 11beta-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus. Diabetes Obes Metab 2012;14:869–81.10.1111/j.1463-1326.2012.01582.xSearch in Google Scholar PubMed

150. Pedersen SB, Jonler M, Richelsen B. Characterization of regional and gender differences in glucocorticoid receptors and lipoprotein lipase activity in human adipose tissue. J Clin Endocrinol Metab 1994;78:1354–9.Search in Google Scholar

151. Rebuffe-Scrive M, Bronnegard M, Nilsson A, Eldh J, Gustafsson JA, Bjorntorp P. Steroid hormone receptors in human adipose tissues. J Clin Endocrinol Metab 1990;71:1215–9.10.1210/jcem-71-5-1215Search in Google Scholar PubMed

152. Veilleux A, Laberge PY, Morency J, Noel S, Luu-The V, Tchernof A. Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue. J Steroid Biochem Mol Biol 2010;122:28–34.10.1016/j.jsbmb.2010.02.024Search in Google Scholar PubMed

153. Peckett AJ, Wright DC, Riddell MC. The effects of glucocorticoids on adipose tissue lipid metabolism. Metabolism 2011;60:1500–10.10.1016/j.metabol.2011.06.012Search in Google Scholar PubMed

154. Matias I, Gonthier MP, Orlando P, Martiadis V, De Petrocellis L, Cervino C, Petrosino S, Hoareau L, Festy F, Pasquali R, Roche R, Maj M, Pagotto U, Monteleone P, Di Marzo V. Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. J Clin Endocrinol Metab 2006;91:3171–80.10.1210/jc.2005-2679Search in Google Scholar PubMed

155. Cota D, Marsicano G, Tschop M, Grubler Y, Flachskamm C, Schubert M, Auer D, Yassouridis A, Thone-Reineke C, Ortmann S, Tomassoni F, Cervino C, Nisoli E, Linthorst AC, Pasquali R, Lutz B, Stalla GK, Pagotto U. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 2003;112:423–31.10.1172/JCI17725Search in Google Scholar PubMed PubMed Central

156. Kola B, Hubina E, Tucci SA, Kirkham TC, Garcia EA, Mitchell SE, Williams LM, Hawley SA, Hardie DG, Grossman AB, Korbonits M. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem 2005;280:25196–201.10.1074/jbc.C500175200Search in Google Scholar PubMed

157. Osei-Hyiaman D, DePetrillo M, Pacher P, Liu J, Radaeva S, Batkai S, Harvey-White J, Mackie K, Offertaler L, Wang L, Kunos G. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest 2005;115:1298–305.10.1172/JCI200523057Search in Google Scholar

158. Engeli S, Bohnke J, Feldpausch M, Gorzelniak K, Janke J, Batkai S, Pacher P, Harvey-White J, Luft FC, Sharma AM, Jordan J. Activation of the peripheral endocannabinoid system in human obesity. Diabetes 2005;54:2838–43.10.2337/diabetes.54.10.2838Search in Google Scholar PubMed PubMed Central

159. Bluher M, Engeli S, Kloting N, Berndt J, Fasshauer M, Batkai S, Pacher P, Schon MR, Jordan J, Stumvoll M. Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes 2006;55:3053–60.10.2337/db06-0812Search in Google Scholar PubMed PubMed Central

160. Cote M, Matias I, Lemieux I, Petrosino S, Almeras N, Despres JP, Di Marzo V. Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. Int J Obes (Lond) 2007;31:692–9.10.1038/sj.ijo.0803539Search in Google Scholar PubMed

161. Simonds SE, Cowley MA, Enriori PJ. Leptin increasing sympathetic nerve outflow in obesity: a cure for obesity or a potential contributor to metabolic syndrome? Adipocyte 2012;1:177–81.10.4161/adip.20690Search in Google Scholar PubMed PubMed Central

162. Zouhal H, Lemoine-Morel S, Mathieu ME, Casazza GA, Jabbour G. Catecholamines and obesity: effects of exercise and training. Sports Med 2013;43:591–600.10.1007/s40279-013-0039-8Search in Google Scholar PubMed

163. Muntzel MS, Al-Naimi OA, Barclay A, Ajasin D. Cafeteria diet increases fat mass and chronically elevates lumbar sympathetic nerve activity in rats. Hypertension 2012;60:1498–502.10.1161/HYPERTENSIONAHA.112.194886Search in Google Scholar PubMed PubMed Central

164. Smith MM, Minson CT. Obesity and adipokines: effects on sympathetic overactivity. J Physiol 2012;590:1787–801.10.1113/jphysiol.2011.221036Search in Google Scholar PubMed PubMed Central

165. Davy KP, Orr JS. Sympathetic nervous system behavior in human obesity. Neurosci Biobehav Rev 2009;33:116–24.10.1016/j.neubiorev.2008.05.024Search in Google Scholar PubMed PubMed Central

166. Andersson J, Karpe F, Sjostrom LG, Riklund K, Soderberg S, Olsson T. Association of adipose tissue blood flow with fat depot sizes and adipokines in women. Int J Obes 2012;36:783–9.10.1038/ijo.2011.152Search in Google Scholar PubMed

167. Viljanen AP, Lautamäki R, Järvisalo M, Parkkola R, Huupponen R, Lehtimäki T, Rönnemaa T, Raitakari OT, Iozzo P, Nuutila P. Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects. Ann Med 2009;41:152–60.10.1080/07853890802446754Search in Google Scholar PubMed

168. Gealekman O, Guseva N, Hartigan C, Apotheker S, Gorgoglione M, Gurav K, Tran KV, Straubhaar J, Nicoloro S, Czech MP, Thompson M, Perugini RA, Corvera S. Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation 2011;123:186–94.10.1161/CIRCULATIONAHA.110.970145Search in Google Scholar PubMed PubMed Central

169. Toth MJ, Tchernof A, Sites CK, Poehlman ET. Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes Relat Metab Disord 2000;24:226–31.10.1038/sj.ijo.0801118Search in Google Scholar

170. Walton C, Godsland IF, Proudler AJ, Wynn V, Stevenson JC. The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women. Eur J Clin Invest 1993;23:466–73.10.1111/j.1365-2362.1993.tb00792.xSearch in Google Scholar

171. Stevenson JC, Crook D, Godsland IF. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis 1993;98:83–90.10.1016/0021-9150(93)90225-JSearch in Google Scholar

172. Homma H, Kurachi H, Nishio Y, Takeda T, Yamamoto T, Adachi K, Morishige K, Ohmichi M, Matsuzawa Y, Murata Y. Estrogen suppresses transcription of lipoprotein lipase gene. Existence of a unique estrogen response element on the lipoprotein lipase promoter. J Biol Chem 2000;275:11404–11.10.1074/jbc.275.15.11404Search in Google Scholar

173. Machinal-Quelin F, Dieudonne MN, Pecquery R, Leneveu MC, Giudicelli Y. Direct in vitro effects of androgens and estrogens on ob gene expression and leptin secretion in human adipose tissue. Endocrine 2002;18:179–84.10.1385/ENDO:18:2:179Search in Google Scholar

174. Babaei P, Mehdizadeh R, Ansar MM, Damirchi A. Effects of ovariectomy and estrogen replacement therapy on visceral adipose tissue and serum adiponectin levels in rats. Menopause Int 2010;16:100–4.10.1258/mi.2010.010028Search in Google Scholar PubMed

175. Pedersen SB, Kristensen K, Hermann PA, Katzenellenbogen JA, Richelsen B. Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution. J Clin Endocrinol Metab 2004;89:1869–78.10.1210/jc.2003-031327Search in Google Scholar PubMed

176. Moon JH, Kim HJ, Kim SK, Kang ES, Lee BW, Ahn CW, Lee HC, Cha BS. Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment. Metabolism 2011;60:165–72.10.1016/j.metabol.2009.12.007Search in Google Scholar PubMed

177. Shadid S, Jensen MD. Effects of pioglitazone versus diet and exercise on metabolic health and fat distribution in upper body obesity. Diabetes Care 2003;26:3148–52.10.2337/diacare.26.11.3148Search in Google Scholar PubMed

178. McLaughlin TM, Liu T, Yee G, Abbasi F, Lamendola C, Reaven GM, Tsao P, Cushman SW, Sherman A. Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue. Obesity (Silver Spring) 2010;18:926–31.10.1038/oby.2009.380Search in Google Scholar PubMed