Accessible Requires Authentication Published by De Gruyter October 16, 2019

The effect of concurrent aerobic-resistance training on thyroid hormones, blood glucose hemostasis, and blood lipid indices in overweight girls with hypothyroidism

Sahar Mohammadi Sefat, Ramin Shabani and Marzieh Nazari ORCID logo



The present study aimed to explore the effect of 8 weeks of concurrent aerobic-resistance training on thyroid stimulating hormone (TSH), thyroxine (T4), blood lipid profile, and blood glucose hemostasis in adolescent girls with hypothyroidism.

Materials and methods

In this clinical trial, 20 adolescent girls with hypothyroidism [age: 12.10 ± 1.94 years; body mass index (BMI): 25.25 ± 2.91 kg/m2] were selected and randomly assigned to experimental and control groups. The experimental group was treated with 8 weeks of concurrent aerobic [60–80% heart rate reserve (HHR)] and resistance (40–65% of 1RM) training. Blood was sampled before and after training. Data were analyzed using a pairwise t-test and an independent t-test (α < 0.05).


Within-group comparison revealed significant decline of body index, BMI, fat percentage, fasting blood sugar, and homeostatic model assessment (HOMA) in the experimental group (p = 0.002, p = 0.001, p = 0.001, p = 0.03, and p = 0.02, respectively). Also, inter-group comparisons indicated significant differences in weight, BMI, fat percentage and HOMA (p = 0.001). But, no significant difference was observed in the blood sugar index (p > 0.05).


A short-term period of concurrent aerobic-resistance training may improve blood glucose hemostasis and body composition of adolescent girls with hypothyroidism. However, further research is necessary.


We gratefully acknowledge the contribution of the study participants.

Author Statement

  1. Research funding: Authors state no funding was involved.

  2. Conflict of interest: All authors declare no conflict of interest.

  3. Informed consent: Every participant signed an informed consent form.

  4. The protocol was registered in the Iranian Clinical Trial Registry, IRCT: 20150531022498N26.

  5. Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies, was performed in accordance to the tenets of the Helsinki Declaration, and was approved by the Ethics Committee of Islamic Azad University of Rasht, Iran (Code No: IR.IAU.RASHT.1395.23).


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Received: 2019-06-08
Accepted: 2019-09-02
Published Online: 2019-10-16

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