Accessible Requires Authentication Published by De Gruyter December 4, 2012

Multifunctional silica nanoparticles for optical and magnetic resonance imaging

Rajendra Joshi, Verena Feldmann, Wolfgang Koestner, Claudia Detje, Sven Gottschalk, Hermann A. Mayer, Martin G. Sauer and Jörn Engelmann
From the journal Biological Chemistry

Abstract

The surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9–16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×105 and ~5×105 /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.


Corresponding authors: Rajendra Joshi and Jörn Engelmann, High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Spemannstrasse 41, D-72076 Tübingen, Germany

Received: 2012-7-12
Accepted: 2012-8-9
Published Online: 2012-12-04
Published in Print: 2013-01-01

©2012 by Walter de Gruyter Berlin Boston