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Licensed Unlicensed Requires Authentication Published by De Gruyter October 23, 2013

Crosstalk of lipid and protein homeostasis to maintain membrane function

Claudius Stordeur, Kristina Puth, James P. Sáenz and Robert Ernst
From the journal Biological Chemistry


Biological membranes are a defining feature of cellular life. They serve as selective diffusion barriers, compartmentalize biochemical processes and protect the cellular milieu. We are only beginning to understand the principles underlying their homeostasis and the functional relevance of their complex compositions. Here, we summarize some recent evidences that suggest an intense crosstalk between the pathways of protein quality control and lipid homeostasis. We discuss paradigms of lipid regulation by protein degradation machineries and highlight the intricate connections between lipid droplet morphology, membrane biogenesis and ER-stress.

Corresponding author: Robert Ernst, Institute of Biochemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany, e-mail:

We apologize to all of our colleagues, whose work could not be cited. R.E. acknowledges Kai Simons and his lab, especially Robin W. Klemm, for important discussions as well as the Deutsche Forschungsgemeinschaft for support (Emmy Noether Program ER608/2-1 and SFB807 Transport and Communication across Biological Membranes).


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Received: 2013-7-31
Accepted: 2013-10-21
Published Online: 2013-10-23
Published in Print: 2014-03-01

©2014 by Walter de Gruyter Berlin Boston