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Licensed Unlicensed Requires Authentication Published by De Gruyter May 29, 2015

Hepatitis C virus and autophagy

Linya Wang and Jing-hsiung James Ou
From the journal Biological Chemistry

Abstract

Autophagy is a catabolic process by which cells remove protein aggregates and damaged organelles for recycling. It can also be used by cells to remove intracellular microbial pathogens, including viruses, in a process known as xenophagy. However, many viruses have developed mechanisms to subvert this intracellular antiviral response and even use this pathway to support their own replications. Hepatitis C virus (HCV) is one such virus and is an important human pathogen that can cause severe liver diseases. Recent studies indicated that HCV could activate the autophagic pathway to support its replication. This review summarizes the current knowledge on the interplay between HCV and autophagy and how this interplay affects HCV replication and host innate immune responses.


Corresponding author: Jing-hsiung James Ou, Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA, e-mail:

Acknowledgments

This work is supported by National Institutes of Diabetes and Digestive and Kidney Diseases grants DK094652, DK100257 and National Cancer Institute CA177337.

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Received: 2015-5-2
Accepted: 2015-5-26
Published Online: 2015-5-29
Published in Print: 2015-11-1

©2015 by De Gruyter

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