Accessible Requires Authentication Published by De Gruyter June 7, 2018

Functional interrelationships between the kallikrein-related peptidases family and the classical kinin system in the human neutrophil

Pamela Ehrenfeld, Kanti D. Bhoola, Carola E. Matus and Carlos D. Figueroa
From the journal Biological Chemistry

Abstract

In the human neutrophil, kallikrein-related peptidases (KLKs) have a significant functional relationship with the classical kinin system as a kinin B1 receptor agonist induces secretion of KLK1, KLK6, KLK10, KLK13 and KLK14 into the medium. Secretion of KLK1, the kinin-forming enzyme, may perpetuate formation of kinin in the inflammatory milieu by hydrolyzing extravasated kininogens present in tissue edema. Secretion of KLKs into the inflammatory milieu, induced by kinins or other proinflammatory mediators, provides the human neutrophil with a wide range of molecular interactions to hydrolyze different cellular and extracellular matrix components, which may be of critical relevance in different mechanisms involving inflammation.

Funding source: Universidad Austral de Chile

Award Identifier / Grant number: S-2015-61

Funding statement: The authors wish to thank Dirección de Investigación y Desarrollo from Universidad Austral de Chile, Funder Id: 10.13039/501100007159 (Grant No. S-2015-61 to P.E.) for its continuous support.

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Received: 2017-12-28
Accepted: 2018-04-15
Published Online: 2018-06-07
Published in Print: 2018-09-25

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