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Licensed Unlicensed Requires Authentication Published by De Gruyter June 30, 2018

The function of sphingomyelinases in mycobacterial infections

  • Yuqing Wu , Erich Gulbins and Heike Grassmé EMAIL logo
From the journal Biological Chemistry


Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest and most important infectious diseases worldwide. The sphingomyelinase/ceramide system, which has been shown several times to be a crucial factor in the internalization, processing and killing of diverse pathogens, also modulates the pro-inflammatory response and the state of mycobacteria in macrophages. Both acid and neutral sphingomyelinases are important in this activity. However, studies of the role of sphingomyelinases in TB are still at an early stage.

Award Identifier / Grant number: GR 1697/2-1

Funding statement: Deutsche Forschungsgemeinschaft, Funder Id: 10.13039/501100001659, Grant Number: GR 1697/2-1.


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Received: 2018-03-09
Accepted: 2018-06-06
Published Online: 2018-06-30
Published in Print: 2018-09-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

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