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Licensed Unlicensed Requires Authentication Published by De Gruyter July 24, 2018

Biological and medical applications of plasma-activated media, water and solutions

  • Nagendra Kumar Kaushik EMAIL logo , Bhagirath Ghimire , Ying Li , Manish Adhikari , Mayura Veerana , Neha Kaushik , Nayansi Jha , Bhawana Adhikari , Su-Jae Lee , Kai Masur , Thomas von Woedtke , Klaus-Dieter Weltmann and Eun Ha Choi EMAIL logo
From the journal Biological Chemistry


Non-thermal atmospheric pressure plasma has been proposed as a new tool for various biological and medical applications. Plasma in close proximity to cell culture media or water creates reactive oxygen and nitrogen species containing solutions known as plasma-activated media (PAM) or plasma-activated water (PAW) – the latter even displays acidification. These plasma-treated solutions remain stable for several days with respect to the storage temperature. Recently, PAM and PAW have been widely studied for many biomedical applications. Here, we reviewed promising reports demonstrating plasma-liquid interaction chemistry and the application of PAM or PAW as an anti-cancer, anti-metastatic, antimicrobial, regenerative medicine for blood coagulation and even as a dental treatment agent. We also discuss the role of PAM on cancer initiation cells (spheroids or cancer stem cells), on the epithelial mesenchymal transition (EMT), and when used for metastasis inhibition considering its anticancer effects. The roles of PAW in controlling plant disease, seed decontamination, seed germination and plant growth are also considered in this review. Finally, we emphasize the future prospects of PAM, PAW or plasma-activated solutions in biomedical applications with a discussion of the mechanisms and the stability and safety issues in relation to humans.


The presented work was supported by a grant from the National Research Foundation of Korea (NRF), which is funded by the Korean Government, Ministry of Science, ICT and Future Planning (MSIP), Funder Id: 10.13039/501100003725, NRF-2016K1A4A3914113 and NRF-2016R1C1B2010851 and as well as supported by TBI-V-1-234-VBW-081. This work was also supported by Kwangwoon University in 2018 and Ministry of Trade; Industry and Energy grant No. 20131610101840.


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Received: 2018-04-18
Accepted: 2018-07-11
Published Online: 2018-07-24
Published in Print: 2018-12-19

©2019 Walter de Gruyter GmbH, Berlin/Boston

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