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Licensed Unlicensed Requires Authentication Published by De Gruyter October 29, 2019

Platelets as a ‘natural factory’ for growth factor production that sustains normal (and pathological) cell biology

  • Sheila Siqueira Andrade EMAIL logo , Alessandra Valéria de Sousa Faria , Dagmar de Paulo Queluz and Carmen Veríssima Ferreira-Halder
From the journal Biological Chemistry


Platelets have attracted substantial attention in the current decade owing to their unexpected pleiotropic properties and conflicted functions. In fact, platelets participate in both health (hemostasis) and disease (thrombotic diseases). Much of the plasticity of platelets comes from the fact that platelets are the reservoir and the ‘natural factory’ of growth factors (GFs), with pivotal functions in wound repair and tissue regeneration. By combining the platelets’ plasticity and biotechnological processes, PlateInnove Biotechnology optimized the production of GFs in nanoparticle biointerfacing by platelet content, which opens an avenue of possibilities.

Award Identifier / Grant number: 2016/14459-3

Award Identifier / Grant number: 2017/26317-1

Funding statement: The authors would like to thank the support of Hemocentro de Campinas/UNICAMP, Colsan (Associação Beneficente de Coleta de Sangue), Hemocentro de Ribeirão Preto/USP, and the São Paulo Research Foundation (FAPESP) under grant 2016/14459-3 and 2017/26317-1.

  1. Conflict of interest statement: Sheila Siqueira Andrade is the founder and Executive Director of PlateInnove Biotechnology, São Paulo, Brazil.


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Supplementary Material

The online version of this article offers supplementary material (

Received: 2019-08-12
Accepted: 2019-10-24
Published Online: 2019-10-29
Published in Print: 2020-03-26

©2020 Walter de Gruyter GmbH, Berlin/Boston

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