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Licensed Unlicensed Requires Authentication Published by De Gruyter January 21, 2022

Photochemical protein modification in complex biological environments: recent advances and considerations for future chemical methods development

Michael T. Taylor ORCID logo
From the journal Biological Chemistry

Abstract

The development of organic reactions that covalently modify biological matter in complex biological mixtures has become an invaluable asset in drug discovery. Out of the techniques developed to date, optically controlled chemistries are of particular utility owing to both the spatiotemporal control afforded by optical control as well as the impressive array of transformations that are driven by the highly reactive intermediates generated upon excitation. This minireview discusses recent advances in the development of photochemical reactions for use in complex mixtures and highlights key considerations for future photochemical reaction designs.


Corresponding author: Michael T. Taylor, Department of Chemistry, University of Wyoming, 1000 E. University Ave., Laramie, WY 82071, USA, E-mail:

Funding source: NIGMS funded Sensory Biology COBREhttp://dx.doi.org./10.13039/100000057

Award Identifier / Grant number: P20 GM121310

Acknowledgments

We thank the NIGMS-funded Wyoming Sensory Biology COBRE program (P20 GM121310) for support.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This review was supported by NIGMS funded Sensory Biology COBRE program (P20 GM121310).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2021-08-20
Accepted: 2022-01-12
Published Online: 2022-01-21
Published in Print: 2022-03-28

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