Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter September 4, 2013

The underexamined association between posttraumatic stress disorder, medical illness and suicidal behavior

  • Yuriy Dobry EMAIL logo and Leo Sher

Abstract

Posttraumatic stress disorder (PTSD) is concerning not only because of the severity and chronicity of its symptoms – including distressing nightmares, flashbacks, anxiety attacks and maladaptive patterns of avoidant and nearly paranoid behavior – but also because of the wide spectrum of clinical and social impairments it is tightly associated with. The most striking example of clinical morbidity associated with PTSD is the well-known increase in the risk of suicidal behavior. Given that PTSD and medical illnesses increase the likelihood of suicide separately and independently, it is reasonable to suggest that the risk of suicidal behavior differs between patients suffering from PTSD comorbid with medical illnesses and patients having either condition alone. The available data point toward a novel clinical notion, an altered risk of suicidal behavior in patients suffering from comorbid PTSD and medical illnesses. This area of overlap between medicine and psychiatry is still in its infancy, with many unanswered questions about the rate, patterns and psychobiological mechanisms of suicidal behavior in this patient population. The positive association between PTSD, medical illness and suicidal behavior that appears to exist in the adult population, most likely affects the pediatric population as well. Closer investigation into the significance of the association between chronic medical illnesses, PTSD and suicidality in children, adolescents and adults is necessary.


Corresponding author: Yuriy Dobry, MD, Department of Psychiatry, Mount Sinai School of Medicine, Box 1240, New York, NY 10029, USA

References

1. Yehuda R. Post-traumatic stress disorder. N Engl J Med 2002;346:108–14.10.1056/NEJMra012941Search in Google Scholar PubMed

2. Friedman MJ, Resick PA, Bryant RA, Brewin CR. Considering PTSD for DSM-5. Depress Anxiety 2011;28:750–69.10.1002/da.20767Search in Google Scholar PubMed

3. Sher L. Recognizing post-traumatic stress disorder. QJM 2004;97:1–5.10.1093/qjmed/hch003Search in Google Scholar PubMed

4. Jones E, Hodgins RV, Mccartney H, Beech C, Palmer I, et al. Flashbacks and post-traumatic stress disorder: the genesis of a 20th-century diagnosis. Br J Psychiatry 2003;182:158–63.10.1192/bjp.182.2.158Search in Google Scholar PubMed

5. Marshall RD, Olfson M, Hellman F, Blanco C, Guardino M, et al. Comorbidity, impairment, and suicidality in subthreshold PTSD. Am J Psychiatry 2001;158:1467–73.10.1176/appi.ajp.158.9.1467Search in Google Scholar PubMed

6. Breslau N, Lucia VC, Davis GC. Partial PTSD versus full PTSD: an empirical examination of associated impairment. Psychol Med 2004;34:1205–14.10.1017/S0033291704002594Search in Google Scholar PubMed

7. Hendin H, Haas AP. Suicide and guilt as manifestations of PTSD in Vietnam combat veterans. Am J Psychiatry 1991;148:586–91.10.1176/ajp.148.5.586Search in Google Scholar PubMed

8. Gradus JL, Qin P, Lincoln AK, Miller M, Lawler E, et al. Posttraumatic stress disorder and suicide. Am J Epidemiol 2010;171:721–7.10.1093/aje/kwp456Search in Google Scholar PubMed

9. Sareen J, Houlahan T, Cox BJ, Asmundson GJG. Anxiety disorders associated with suicidal ideation and suicide attempts in the National Comorbidity Survey. J Nerv Ment Dis 2005;193:450–4.10.1097/01.nmd.0000168263.89652.6bSearch in Google Scholar PubMed

10. Krysinska K, Lester D. Post-traumatic stress disorder and suicide risk: a systematic review. Arch Suicide Res 2010; 14:1–23.10.1080/13811110903478997Search in Google Scholar PubMed

11. Sareen J, Cox BJ, Stein MB, Afifi TO, Fleet C, et al. Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample. Psychosom Med 2007;69:242–8.10.1097/PSY.0b013e31803146d8Search in Google Scholar

12. Wentworth BA, Stein M, Redwine L, Xue, Y, Taub P, et al. Post-traumatic stress disorder: a fast track to premature cardiovascular disease? Cardiol Rev 2013;21:16–22.10.1097/CRD.0b013e318265343bSearch in Google Scholar

13. Tseng MC, Cheng IC, Hu FC. Standardized mortality ratio of inpatient suicide in a general hospital. J Formos Med Assoc 2011;110:267–9.10.1016/S0929-6646(11)60040-5Search in Google Scholar

14. Freeman TW, Roca V, Moore WM. A comparison of chronic combat-related posttraumatic stress disorder (PTSD) patients with and without a history of suicide attempt. J Nerv Ment Dis 2000;188:460–3.10.1097/00005053-200007000-00011Search in Google Scholar PubMed

15. Brenner LA, Betthauser LM, Homaifar BY, Villarreal E, Harwood JE, et al. Posttraumatic stress disorder, traumatic brain injury, and suicide attempt history among veterans receiving mental health services. Suicide Life Threat Behav 2011;41:416–23.10.1111/j.1943-278X.2011.00041.xSearch in Google Scholar PubMed

16. Barnes SM, Walter KH, Chard KM. Does a history of mild traumatic brain injury increase suicide risk in veterans with PTSD? Rehabil Psychol 2012;57:18–26.10.1037/a0027007Search in Google Scholar PubMed

17. McGarvey EL, Canterbury RJ, Koopman C, Clavet GJ, Cohen R, et al. Acute stress disorder following acute stress. Int J Rehab Health 2005;73:360–4.Search in Google Scholar

18. Seckl JR, Meaney MJ. Glucocorticoid “programming” and PTSD risk. Ann NY Acad Sci 2006;171:351–78.Search in Google Scholar

19. von Känel R, Begré S, Abbas CC, Saner H, Gander ML, et al. Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms. Neuroimmunomodulation 2010;17: 39–46.10.1159/000243084Search in Google Scholar PubMed

20. Stuber ML, Shemesh E. Post-traumatic stress response to life-threatening illnesses in children and their parents. Child Adolesc Psychiatr Clin North Am 2006;15:597–609.10.1016/j.chc.2006.02.006Search in Google Scholar PubMed

21. Seedat S, Lockhat R, Kaminer D, Zungu-Dirwayi N, Stein DJ. An open trial of citalopram in adolescents with post-traumatic stress disorder. Int Clin Psychopharm 2001;16:21–5.10.1097/00004850-200101000-00002Search in Google Scholar PubMed

22. Vajda J, Steibeck K. Factors associated with repeat suicide attempts among adolescents. Aust NZ J Psychiatry 2000;34:437–45.10.1080/j.1440-1614.2000.00712.xSearch in Google Scholar PubMed

23. Lipschitz DS. Winegar RK, Hartnick E, Foote B, Southwick SM. Posttraumatic stress disorder in hospitalized adolescents: psychiatric comorbidity and clinical correlates. J Am Acad Child Adolesc Psychiatry 1999;38:385–92.10.1097/00004583-199904000-00010Search in Google Scholar PubMed

Received: 2012-10-18
Accepted: 2012-12-3
Published Online: 2013-09-04
Published in Print: 2013-09-01

©2013 by Walter de Gruyter Berlin Boston

Downloaded on 4.6.2023 from https://www.degruyter.com/document/doi/10.1515/ijamh-2013-0063/html
Scroll to top button