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Publicly Available Published by De Gruyter November 30, 2016

Lomefloxacin Degradation: Antimicrobial Activity, Toxicity and Byproducts

Amanda M. D. de Oliveira , Milena G. Maniero and José R. Guimarães EMAIL logo

Abstract

Lomefloxacin (LOM) is an important antimicrobial drug. It has been detected in aqueous matrices in several countries. Its continuous introduction into the environment is a potential risk to aquatic and terrestrial organisms. The aim of this study was to evaluate the degradation of LOM by photolysis, peroxidation, and peroxidation assisted by ultraviolet radiation; moreover, the residual antimicrobial activity, the toxicity, and the byproducts formed during degradation processes were evaluated. Peroxidation was inefficient for LOM degradation and was not able to reduce antimicrobial activity. Both photolysis and UV/H2O2 were able to degrade more than 95% of LOM in 60 min (radiation dose of 5267 mJ cm-2). However, toxicity increased while these processes were being applied. For all processes evaluated, antimicrobial activity was still detected in the solution after 60 min of testing. Four byproducts were identified: m/z 332, 336, 348, and 350.

Received: 2014-11-4
Revised: 2015-2-20
Accepted: 2015-2-21
Published Online: 2016-11-30
Published in Print: 2015-7-1

© 2016 by Walter de Gruyter Berlin/Boston

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