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Licensed Unlicensed Requires Authentication Published by De Gruyter November 21, 2013

Gene functional dynamics: environment as a trigger?

  • Eliyahu G. Stoupel EMAIL logo


Recent decades have seen the deciphering of the human genome and, also, progress in studies related to the effects of space-weather on humans. The progress in genetics allows us to connect many human pathologies with specific gene abnormalities. Concomitantly it has been shown that many congenital and adherent diseases, and the timing of death are connected with space factors such as solar activity (SA), geomagnetic activity (GMA), cosmic ray activity (CRA), and space neutron and proton flux. Here arises the question to what extent gene expression is affected by the aforementioned space physical activity parameters. This is the motto of this hypothetical paper. In conclusion, the space-weather-related timing of many medical events invites presumption that gene activity is a changing phenomenon and space weather components may be playing a regulatory role in these changes.

Corresponding author: Eliyahu G. Stoupel, Rabin Medical Center, Division of Cardiology, Sackler Faculty of Medicine, Tel Aviv University, Denmark 2 Petah Tiqwa 49100, Israel, Phone: +972-3-9377351, E-mail:


1. Human genome project genomic energy. US Department of Energy, 2012:1–4.Search in Google Scholar

2. Read AP, Donnai D. New clinical genetics. Banbury: Scion, 2011:442pp.Search in Google Scholar

3. Firth H, Hurst JA, Hall JG. Clinical genetics. Oxford: Oxford University Press, 2005:851pp.Search in Google Scholar

4. Jorde LB, Carrey JC, Bamshad MJ. Medical Genetics. Philadelphia: Mosby/Elsevier, 2010:350pp.10.1016/B978-0-323-05373-0.00011-7Search in Google Scholar

5. NOAA SWPC-USAF. Preliminary report and forecast of solar geophysical data, weekly. Available at: http://www.SWPC.Search in Google Scholar

6. NOAA National Geophysical Data Center. Solar indices bulletin, monthly. Available at: http://www.SWPC.Search in Google Scholar

7. NOAA National Geophysical Data Center. Geomagnetic indices bulletin, monthly. Available at: http://www.SWPC.Search in Google Scholar

8. NOAA-USAF. SESC glossary of solar-terrestrial terms. Boulder, 1992:69pp. Available at: http://www.SWPC.Search in Google Scholar

9. Russian Academy of Sciences. Izmiran Institute cosmic data, monthly.Search in Google Scholar

10. Russian Academy of Sciences. Moscow Neutron Monitoring Station daily, monthly, yearly neutron monitoring data.Search in Google Scholar

11. Oulu University. Neutron monitoring data, daily, monthly.Search in Google Scholar

12. Rochman B. The DNA dilemma: a test that could change your life. Time Magazine 2012;26:30–35.Search in Google Scholar

13. Doblhammer G, Vaupel JW. Lifespan depends on month of birth. PNAS 2001;98:2934–9.10.1073/pnas.041431898Search in Google Scholar

14. Gavrilov LA, Gavrilova NS. Season of birth and exceptional longevity: comparative study of american centenarians, their siblings and spouses. J Aging Res 2011;104616:1–11.Search in Google Scholar

15. Stoupel E, Abramson E, Israelevich P, Sulkes J. Birth month and longevity-monthly birth distribution in acute coronary events provoked by atherothrombosis in patients treated with percutaneous coronary intervention (PCI). J Basic Clin Physiol Pharmacol 2011;23:43–7.10.1515/jbcpp.2011.003Search in Google Scholar

16. Stoupel E, Tamoshiunas A, Radishauskas R, Bernotiene G, Abramson E, Israelevich P. Acute myocardial Infarction (AMI) in context with the paradigm-month of birth and longevity. Health 2011;3:732–6.10.4236/health.2011.312121Search in Google Scholar

17. Stoupel E, Abramson E, Fenig E. Birth month of patients with malignant neoplasms: links to longevity? J Basic Clin Physiol Pharmacol 2012;23:57–60.10.1515/jbcpp-2012-0025Search in Google Scholar

18. Stoupel E, Tamoshiunas A, Radishauskas R, Abramson E, Bernotiene G, Bacevichiene M. Birth month and longevity: birth month of victims of sudden (SCD ≤1h.) and rapid (≤24h.) cardiac death. J Basic Clin Physiol Pharmacol 2013;24:1–5.Search in Google Scholar

19. Stoupel E, Kalediene R, Petrauskiene J, Starkuviene S, Abramson E, Israelevich P, et al. Twenty years study of solar, geomagnetic, cosmic ray activity links with monthly deaths number (n-850304). J Biomedic Sci Eng 2011;4:426–34.10.4236/jbise.2011.46054Search in Google Scholar

20. Stoupel E. Effect of geomagnetic activity on cardiovascular parameters. Biomed Pharmacother 2002;56:247s–56s.10.1016/S0753-3322(02)00299-8Search in Google Scholar

21. Stoupel E, Tamoshiunas A, Radishauskas R, Bernotiene G, Abramson E, Israelevich P. Neutrons and the plaque: AMI (n-8920) at days of zero GMA/high neutron activity (n-36) and the following days and week. Kaunas, Lithuania, 2000–2007. J Clin & Exper Cardiology 2011;2:1–4.Search in Google Scholar

22. Stoupel E. Solar-terrestrial predictions-aspects for preventive medicine. In: Donnelly RF, editor. Solar-terrestrial prediction proceedings, vol. 4. Boulder: National Oceanic Atmospheric Administration, Environmental Research Laboratories, 1980:G29–40.Search in Google Scholar

23. Stoupel E, Petrauskiene J, Kalediene R, Domarkiene S, Abramson E, Sulkes J. Distribution of deaths from ischemic heart disease and stroke. Environmental and aging influences in men and women. J Basic Clin Physiol Pharmacol 1996;7:303–19.10.1515/JBCPP.1996.7.4.303Search in Google Scholar

24. Stoupel E, Domarkiene S, Radishauskas R, Abramson E, Sulkes J. Deaths from ischemic and hemorrhagic stroke on days of different levels of geomagnetic activity (GMA). Semin Cardiol 2003;9:46–51.Search in Google Scholar

25. Stoupel E. Clinical cosmobiology. BEMI Currents (Newsletter of the Bio-Electro-Magnetics Institute) 1989;1:1–2.Search in Google Scholar

26. Stoupel E, Shimshoni M. Some strange changes in hospital mortality from acute myocardial infarction (1981–1986/versus 1974–1980). Abstracts of European Congress of Cardiology. Eur Heart J 1988;9(Suppl 1):161.Search in Google Scholar

27. Stoupel E, Kalediene R, Petrauskiene J, Domarkiene S, Radishauskas R, Abramson E, et al. Three kinds of cosmophysical activity-links to temporal distribution of deaths and occurrence of acute myocardial infarction. Med Sci Monit 2004;10:CR80–4.Search in Google Scholar

28. Stoupel E. Forecasting in cardiology. New York, Toronto, Jerusalem: John Wiley & Sons, 1976:141pp.Search in Google Scholar

29. Stoupel E. Atherothrombosis: environmental links. J Basic Clin Physiol Pharmacol 2008;19:37–45.10.1515/JBCPP.2008.19.1.37Search in Google Scholar

30. Stoupel E, Domarkiene S, Radishauskas R, Bernotiene G, Abramson E, Israelevich P, et al. Links between monthly rates of four subtypes of acute myocardial infarction and their corresponding cosmophysical activity parameters. J Basic Clin Physiol Pharmacol 2004;15:175–84.10.1515/JBCPP.2004.15.3-4.175Search in Google Scholar PubMed

31. Stoupel E, Babayev E, Mustafa F, Abramson E, Israelevich P, Sulkes J. Acute myocardial infarction occurrence: Environmental links-Baku, 2003–2005. Med Sci Monit 2007;13 175–79.Search in Google Scholar

32. Stoupel E, Assali A, Teplitzky I, Israelevich P, Abramson E, Sulkes J, et al. The culprit artery in acute myocardial infarction in different environmental physical activity levels. Int J Cardiol 2008;126:288–90.10.1016/j.ijcard.2007.05.050Search in Google Scholar PubMed

33. Stoupel E, Abramson E, Israelevich P. Left anterior descending (LAD)/right coronary artery (RCA) as culprit arteries in acute myocardial infarction (AMI) (n-2011) in changing physical environment, percutaneous coronary intervention (PCI) data, 2000–2010. J Basic Clin Physiol Pharmacol 2011;22:91–6.10.1515/JBCPP.2011.024Search in Google Scholar PubMed

34. Stoupel E, Joshua H, Lahav J. Human blood coagulation and geomagnetic activity. Eur J Int Med 1996;7:217–20.Search in Google Scholar

35. Stoupel E, Abramson E, Israelevich P, Sulkes J, Harell D. Dynamics of C-reactive protein (CRP) – environmental links. Eur J Int Med 2007;18:124–8.10.1016/j.ejim.2006.09.010Search in Google Scholar PubMed

36. Stoupel E. Sudden cardiac deaths and ventricular extrasystoles on days with four levels of geomagnetic activity. J Basic Clin Physiol Pharmacol 1993;4:357–66.10.1515/JBCPP.1993.4.4.357Search in Google Scholar PubMed

37. Stoupel E, Domarkiene S, Radishauskas R, Abramson E. Bastille Day event and sudden cardiac death. Semin Cardiol 2002;8: 18–21.Search in Google Scholar

38. Stoupel E. Cardiac arrhythmia and geomagnetic activity. Indian Pacing Electrophysiol J 2006;6:49–53.Search in Google Scholar

39. Stoupel E, Kusniec J, Mazur A, Zabarsky R, Golovchiner G, Abramson E, et al. Temporal relationship of implantable cardioverter defibrillator discharges and environmental physical activity. Pacing Clin Electrophysiol 2005;28:771–81.10.1111/j.1540-8159.2005.00187_2.xSearch in Google Scholar PubMed

40. Stoupel E, Kusniec J, Mazur A, Abramson E, Israelevich P, Strasberg B. Timing of life-threatening arrhythmias detected by implatable cadioverter-defibrillators in relation to changes in cosmophysical factors. Cardiol J 2008;15:437–40.Search in Google Scholar

41. Stoupel E, Domarkiene S, Radishauskas R, Abramson E, Israelevich P, Sulkes J. Neutrons & sudden cardiac death (SCD) Codes 121-125. ICD 10. J Basic Clin Physiol Pharmacol 2006;17:45–54.Search in Google Scholar

42. Stoupel E, Babayev E, Mustafa F, Abramson E, Israelevich P, Sulkes J. Clinical Cosmobiology-sudden cardiac death and daily/monthly geomagnetic, cosmic ray, and solar activity-the Baku Study, 2003–2005. Sun Geosphere 2006;1:13–6.Search in Google Scholar

43. Stoupel E. Relationship of magnetic field and electron splitting in conditions of low geomagnetic activity with sudden cardiac death [abstract]. Europace 2000;1:Suppl A:A17.Search in Google Scholar

44. Stoupel E, Abramson E, Gabbay U, Pick AI. Relationship between immunoglobulin levels and extremes of solar activity. Int J Biometeorol 1995;38:89–91.10.1007/BF01270665Search in Google Scholar PubMed

45. Stoupel E, Monselize Y, Lahav J. Changes in autoimmune markers of the anti cardiolipin syndrome on days of extreme geomagnetic activity. J Basic Clin Physiol Pharmacol 2006;17:269–78.10.1515/JBCPP.2006.17.4.269Search in Google Scholar PubMed

46. Stoupel E, Keret R, Assa S, Kaufman H, Shimshoni M, Laron Z. Secretion of growth hormone, prolactin and corticosteroids during different levels of geomagnetic activity. Neuro Endocrinol Lett 1983;5:365–58.Search in Google Scholar

47. Stoupel E, Keret R, Gil-Ad I, Assa S, Silbergeld A, Shimshoni M, et al. Secretion of growth hormone and prolactin in extreme periods of solar activity in solar cycle 21 (1976–1986). Neuro Endocrinol Lett 1980;5:191–5.Search in Google Scholar

48. Stoupel E, Goldenfeld M, Shimshoni M, Siegel R. Intraocular pressure (IOP) in relation to four levels of daily geomagnetic and extreme yearly solar activity. Int J Biometeorol 1993;37:42–5.10.1007/BF01212766Search in Google Scholar PubMed

49. Stoupel E, Kremer I, Gutmacher L, Abramson E, Yasur I. Acute glaucoma and reticular detachment at four daily levels of geomagnetic activity. 11th International Conference on High-Power Electromagnetics, EuroEM-98, Tel Aviv, June 14–19 1998. Abstracts p.192.Search in Google Scholar

50. Kuritzky A, Zoldan Y, Hering R, Stoupel E. Geomagnetic activity and severity of the migraine attack. Headache 1987;27:87–9.10.1111/j.1526-4610.1987.hed2702087.xSearch in Google Scholar PubMed

51. Merlob P, Reisner SH, Shimshoni M, Stoupel E. Fetal growth in periods of extreme solar activity. J Foetal Med 1989;9:1–4.Search in Google Scholar

52. Galpern G, Stoupel E, Barkai G, Chaki R, Legum C, Feigin M, et al. Solar activity and the incidence of foetal chromosome abnormalities detected at prenatal diagnosis. Int J Biometeorol 1995;39:59–63.10.1007/BF01212581Search in Google Scholar PubMed

53. Stoupel E, Frimer H, Appelman Z, Ben-Neriah Z, Dar H, Feigin MD, et al. Chromosome aberration and environmental physical activity: Down syndrome and solar and cosmic ray activity. Israel 1990–2000. Int J Biometeorol 2005;28:1–9.10.1007/s00484-005-0274-2Search in Google Scholar PubMed

54. Stoupel E, Kalediene R, Petrauskiene J, Starkuviene S, Abramson E, Israelevich P, et al. Suicide-homicide interrelationship, links with other fatalities, and environmental physical activity. Crisis 2005;26:85–9.10.1027/0227-5910.26.2.85Search in Google Scholar

55. Siuniayev PA, editor. Physics of the cosmos. Moscow: Sovietskaya Encyclopedia, 1986:783pp.Search in Google Scholar

56. Kirby AJ, Hollfelder F. Enzymes under nanoscope. Nature 2008;456:45–7.10.1038/456045aSearch in Google Scholar PubMed

57. Feinmann R. The character of physical law. London: MIT Press, 1973, 1994:173pp.Search in Google Scholar

Received: 2013-7-31
Accepted: 2013-9-24
Published Online: 2013-11-21
Published in Print: 2014-5-1

©2014 by Walter de Gruyter Berlin/Boston

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