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Licensed Unlicensed Requires Authentication Published by De Gruyter April 21, 2014

Gastroprotective activity of essential oils from turmeric and ginger

  • Vijayasteltar B. Liju , Kottarapat Jeena and Ramadasan Kuttan EMAIL logo


Background: Turmeric (Curcuma longa) and ginger (Zingiber officianale) are widely used in Asian countries as traditional medicine and food ingredients. In the present study, we have evaluated the gastroprotective activity of turmeric essential oil (TEO) and ginger essential oil (GEO) in rats.

Methods: Turmeric and ginger were evaluated for their antiulcer activity against ethanol-induced ulcers in male Wistar rats at different doses: 100, 500 and 1000 mg/kg body weight. Ethanol was used to induce gastric ulcer in Wistar rats. Parameters such as ulcer index, histopathology and levels of antioxidant enzymes such as glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase and glutathione (GSH) levels were measured to assess the degree of protection produced by the essential oils.

Results: TEO and GEO inhibited ulcer by 84.7% and 85.1%, respectively, as seen from the ulcer index. Reduced antioxidant enzymes such as GPx, SOD, catalase and GSH produced by alcohol administration were significantly (p<0.001) increased by simultaneous administration of TEO and GEO. Histopathological examination showed that ethanol-induced lesions such as necrosis, erosion and hemorrhage of the stomach wall were significantly reduced after oral administration of essential oils.

Conclusions: Results suggest that TEO and GEO could reduce the gastric ulcer in rat stomach as seen from the ulcer index and histopathology of the stomach. Moreover, oxidative stress produced by ethanol was found to be significantly reduced by TEO and GEO.

Corresponding author: Dr. Ramadasan Kuttan, PhD, Research Director, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala-680 555, India, Phone: +91-487-2307968, Fax: +91-487-2307968, E-mail: ;


The authors thank Spices Board, Cochin, India for providing funds (grant no. MD/M&H/01/2008-09) to carry out this work.

Conflict of interest statement

Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article. Research funding played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Research funding: The financial support for this work was provided by Spices Board, Cochin, India.

Employment or leadership: None declared.

Honorarium: None declared.


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Received: 2013-12-20
Accepted: 2014-3-5
Published Online: 2014-4-21
Published in Print: 2015-1-1

©2015 by De Gruyter

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