Accessible Unlicensed Requires Authentication Published by De Gruyter January 11, 2017

Meteorological parameters and pollutants on asthma exacerbation in Bangalore, India – an ecological retrospective time-series study

Kirthana U. Kunikullaya ORCID logo, Ambarish Vijayaraghava, P. Asha, Radhika Kunnavil and B.V. MuraliMohan

Abstract

Background:

Literature has shown a significant association between asthma exacerbations and pollutant levels during that time. There is very limited evidence in India, especially Bangalore, for impacts of meteorological changes and pollution on asthma hospital admissions in adults. The objective was to study the impact of air pollution and meteorological parameters on asthma exacerbation in Bangalore.

Methods:

This study quantitatively analyzed the relation between acute exacerbations of asthma and related admissions to the hospital with the air pollution and the meteorological conditions during that time. Data regarding the daily hospital admissions in about 13 tertiary care centers in Bangalore, Karnataka and air pollutant levels and the meteorological conditions prevailing during each day over a year were collected from the Karnataka State pollution control board and meteorology departments, respectively.

Results:

An average daily asthma admission of 4.84±2.91, with clear seasonal variation and autocorrelations between meteorological parameters and pollutants was observed. Multiple linear regression analysis revealed that average temperature (p=0.005) and nitrogen dioxide (NO2) (p=0.034) were the two factors that were affecting the number of admissions. Quasi-poisson regression analysis using multi-pollutants and meteorological variables showed that particulate matter and NO2 had significant lag effect for up to 5 days (p<0.05) and rainfall for 1 day (p<0.001).

Conclusions:

In Bangalore city, levels of NO2 and particulate matter, temperature, rainfall, and season increase asthma exacerbations.


Corresponding author: Dr. Kirthana U. Kunikullaya, MD, DNB, Assistant Professor, Department of Physiology, M S Ramaiah Medical College and Teaching Hospitals, Bangalore, Karnataka, India, Phone: +91-9742334950

Acknowledgments

We acknowledge the support received by Dr. Ramesh Reddy, Dr. Kedar Hibare and Dr. Kavitha Rajarathna. We thank all the hospitals for co-operating with us during the collection of the data.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. BVM, UKK, AV and AP were responsible for the study conception and design. UKK and AP performed the data collection and compilation. UKK and RK performed the statistical analysis and interpretation of data. UKK, AV, AP and BVM were responsible for drafting and editing the manuscript. UKK agrees to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors reviewed, edited and approved the final manuscript.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Supplemental Material:

The online version of this article (DOI: 10.1515/jbcpp-2016-0074) offers supplementary material, available to authorized users.

Received: 2016-5-11
Accepted: 2016-10-27
Published Online: 2017-1-11
Published in Print: 2017-3-1

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