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Licensed Unlicensed Requires Authentication Published by De Gruyter April 19, 2018

Rabbits and men: relating their ages

Sulagna Dutta and Pallav Sengupta ORCID logo


Rabbit, a member of the Lagomorpha order, is the closest phylogenetic relative to humans, next to primates. It possesses greater acceptability as a laboratory mammal than primates in terms of husbandry, breeding ease, cost effectiveness, and legal ethical conveniences. Moreover, as a laboratory animal, the rabbit also owns its advantages over mice or rats, in terms of phylogenetic resemblance to human, size, blood volume, responsiveness, and other congruences enabling them to better imitate human physiological characteristics in biomedical research. A specific research aspires to effectuate its outcome on a particular human age group, for which it is pivotal to select a laboratory rabbit of exact age, which will correlate with that specific age of a human, which is currently based on mere approximation. This article is the first ever scientific venture, focused to swap this approximation of laboratory rabbit age with accuracy by relating it with that of humans analyzing different phases of life individually. Considering the diminutive lifespan of rabbits compared to humans, the correlation of their age with respect to the entire lifespan, which we found out to be 45.625 days compared to one human year, is not enough. Thereby, like our previous articles that formulated concise relation of age of laboratory rats and mice with human age, in this article also, we aim to aid biomedical research specificity in the selection of laboratory model age, separately correlating different life phases of humans with that of rabbits, the second mostly used mammal in 2016 in the United States.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


1. Liebschner MA. Biomechanical considerations of animal models used in tissue engineering of bone. Biomaterials 2004;25:1697–714.10.1016/S0142-9612(03)00515-5Search in Google Scholar PubMed

2. Pritchett-Corning K, Girod A, Avellaneda G, Fritz PE, Chou S, Brown M. Handbook of clinical signs in rodents and rabbits, 1st ed. Wilmington: Charles River, 2010.Search in Google Scholar

3. Graur D, Duret L, Gouy M. Phylogenetic position of the order Lagomorpha (rabbits, hares and allies). Nature 1996;379:333–5.10.1038/379333a0Search in Google Scholar PubMed

4. Mapara M, Thomas BS, Bhat KM. Rabbit as an animal model for experimental research. Dent Res J (Isfahan) 2012;9:111–8.10.4103/1735-3327.92960Search in Google Scholar PubMed PubMed Central

5. Stone LM. Rabbit breeds: a pocket guide to 49 essential breeds, 1st ed. North Adams, MA: Storey Publishing, 2016.Search in Google Scholar

6. American Rabbit Breeders Association (ARBA), 2016. ARBA recognized breeds. ( [Last accessed on September 12, 2017].Search in Google Scholar

7. Fox RR. The biology of the laboratory rabbit. In: S.H. Weisbroth REF, A.L. Kraus, editors. Toxonomy and genetics. New York: Academic Press, 1974:1–22.Search in Google Scholar

8. Sengupta P. The laboratory rat: relating its age with human’s. Int J Prev Med 2013;4:624–30.Search in Google Scholar

9. USDA/APHIS. The statistics on the number of animals used for experimental and other scientific purposes. Report of European Union, 2010.Search in Google Scholar

10. USDA/APHIS. Annual report animal usage by fiscal year. United States Department of Agriculture (USDA): Animal and Plant Health Inspection Service (APHIS), 2016:1–10.Search in Google Scholar

11. USDA/APHIS. Annual report animal usage by fiscal year. United States Department of Agriculture (USDA): Animal and Plant Health Inspection Service (APHIS), 2015:1–10.Search in Google Scholar

12. USDA/APHIS. Number of animals used in research from the first reporting year (FY 1973) to the present, in Animal Care Annual Report of Activities: Fiscal Year 2007. U. S. Department of Agriculture: Animal and Plant Healthcare Inspection Service.Search in Google Scholar

13. National Anti-vivisection Society (NAVS). Rabbits in Research. 2017. ( [Last accessed on September 12, 2017].Search in Google Scholar

14. National Anti-vivisection Society (NAVS). Animal Research Numbers Continue Downward Trend According to Newly-Released Report. 2017. ( [Last accessed on September 12, 2017].Search in Google Scholar

15. USDA/APHIS. Annual report animal usage by fiscal year. United States Department of Agriculture (USDA): Animal and Plant Health Inspection Service (APHIS), 2014:1–10.Search in Google Scholar

16. Russell RJ, Schilling PW. The rabbit. San Antonio, TX: Aeromed. USAF School of Aerospace Medicine, Brooks Airforce Base, 1973.Search in Google Scholar

17. Dutta S, Sengupta P. Men and mice: relating their ages. Life Sci 2016;152:244–8.10.1016/j.lfs.2015.10.025Search in Google Scholar PubMed

18. Sheail J. Rabbits and their history. North Pomfret, VT: David & Charles Inc., 1971.Search in Google Scholar

19. Roscoe B. The Jackson Laboratory. In: Green MC, Witham BA, editors. Handbook on genetically standardized JAX rabbits, 1st ed. Bar Harbor, ME: Jackson Laboratory, 1975.Search in Google Scholar

20. Manning PJ, Ringler DH, Newcomer CE. The biology of the laboratory rabbit, 2nd ed. San Diego, California: Academic Press, 2014.Search in Google Scholar

21. Suckow MA, Stevens KA, Wilson RP. The laboratory rabbit, guinea pig, hamster, and other rodents, 1st ed. California: Academic Press, 2012.Search in Google Scholar

22. Vinardell MP, Mitjans M. Alternative methods for eye and skin irritation tests: an overview. J Pharm Sci 2008;97:46–59.10.1002/jps.21088Search in Google Scholar PubMed

23. Tsang HG, Rashdan NA, Whitelaw CB, Corcoran BM, Summers KM, MacRae VE. Large animal models of cardiovascular disease. Cell Biochem Func 2016;34:113–32.10.1002/cbf.3173Search in Google Scholar PubMed PubMed Central

24. Woodruff-Pak DS. Animal models of Alzheimer’s disease: therapeutic implications. J Alz Dis 2008;15:507–21.10.3233/JAD-2008-15401Search in Google Scholar PubMed

25. Jiang X, Totrov M, Li W, Sampson JM, Williams C, Lu H, et al. Rationally designed immunogens targeting HIV-1 gp120 V1V2 induce distinct conformation-specific antibody responses in rabbits. J Virol 2016;90:11007–9.10.1128/JVI.01409-16Search in Google Scholar PubMed PubMed Central

26. Townsley S, Mohamed Z, Guo W, McKenna J, Cleveland B, LaBranche C, et al. Induction of heterologous tier 2 HIV-1-neutralizing and cross-reactive V1/V2-specific antibodies in rabbits by prime-boost immunization. J Virol 2016;90:8644–60.10.1128/JVI.00853-16Search in Google Scholar PubMed PubMed Central

27. Prieto V, Ludwig JM, Farris AB, Nagaraju GP, Lawal TO, El-Rayes B, et al. Establishment of human metastatic colorectal cancer model in rabbit liver: a pilot study. PLoS One 2017;12:e0177212.10.1371/journal.pone.0177212Search in Google Scholar PubMed PubMed Central

28. Eifler AC, Lewandowski RJ, Virmani S, Chung JC, Wang D, Tang RL, et al. Development of a VX2 pancreatic cancer model in rabbits: a pilot study. J Vasc Int Radiol 2009;20:1075–82.10.1016/j.jvir.2009.04.051Search in Google Scholar

29. Foote RH, Carney EW. The rabbit as a model for reproductive and developmental toxicity studies. Reprod Toxicol 2000;14:477–93.10.1016/S0890-6238(00)00101-5Search in Google Scholar PubMed

30. Del Amo EM, Urtti A. Rabbit as an animal model for intravitreal pharmacokinetics: clinical predictability and quality of the published data. Exp Eye Res 2015;137:111–24.10.1016/j.exer.2015.05.003Search in Google Scholar PubMed

31. Zhang D, He K, Raghavan N, Wang L, Mitroka J, Maxwell BD, et al. Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans. Drug Metab Dispos 2009;37:1738–48.10.1124/dmd.108.025981Search in Google Scholar PubMed

32. Southern HN. The ecology and population dynamics of the wild rabbit, Oryctolagus cuniculus (L.). Ann Appl Biol 1940;27:509–26.10.1111/j.1744-7348.1940.tb07522.xSearch in Google Scholar

33. Watson JS, Tyndale-Biscoe CH. The apophyseal line as an indicator of age for the wild rabbit (Oryctolaguscuniculus L.). New Zealand J Sci Technol 1953;34:427–35.Search in Google Scholar

34. Tyndale-Biscoe CH, Williams RM. A study of natural mortality in a wild population of the rabbit, Oryctolagus cuniculus. New Zealand J Sci Technol 1955;36:561–80.Search in Google Scholar

35. Lord RD. The lens as an indicator of age in cottontail rabbits. J Wildl Manag 1959;23:109–11.10.2307/3796900Search in Google Scholar

36. Tiemeier OW, Plenert ML. A comparison of three methods for determining the age of black-tailed jack rabbits. J Mammal 1964;45:409–16.10.2307/1377413Search in Google Scholar

37. Bujalska G, Cabon-Raczynska K, Raczynski J. Studies on the European hare. VI. Comparison of different criteria of age. Acta Theriol 1965;10:1–10.10.4098/AT.arch.65-1Search in Google Scholar

38. Connolly GE, Dudzinski ML, Longhurst WM. The eye lens as an indicator of age in the black-tailed jack rabbit. J Wildl Manag 1969;33:159–64.10.2307/3799664Search in Google Scholar

39. Ohtaishi N, Hachiya N, Shibata Y. Age determination of the hare from annual layers in the mandibular bone. Acta Theriol 1976;21:168–71.10.4098/AT.arch.76-13Search in Google Scholar

40. Edwards WR. Tables for estimating ages and birth dates of cottontail rabbits: with suggestion for handling lenses. Urbana, Illinois: Department of Registration and Education, Natural History Survey Division, 1967:1–4.10.5962/bhl.title.15156Search in Google Scholar

41. Augusteyn RC. On the relationship between rabbit age and lens dry weight: improved determination of the age of rabbits in the wild. Mol Vis 2007;13:2030–4.Search in Google Scholar PubMed

42. Rongstad OJ. A cottontail rabbit lens-growth curve from southern Wisconsin. J Wildl Manag 1996;30:114–21.10.2307/3797890Search in Google Scholar

43. Taylor RH. Age determination in wild rabbits. Nature 1959;184:1158–9.10.1038/1841158b0Search in Google Scholar

44. Watson JS. Reproduction of the wild rabbit, Oryctolagus cuniculus (L.) in Hawke’s Bay, New Zealand. New Zealand J Sci Technol 1957;38:451.Search in Google Scholar

45. Bull PC. Incidence of coccidia (sporozoa) in wild rabbits, Oryctolagus cuniculus (L.), in Hawk’s Bay New Zealand. New Zealand J Sci 1958;1:289–329.Search in Google Scholar

46. Kohn LA, Olson P, Cheverud JM. Age of epiphyseal closure in tamarins and marmosets. Am J Primatol 1997;41:129–39.10.1002/(SICI)1098-2345(1997)41:2<129::AID-AJP5>3.0.CO;2-ZSearch in Google Scholar PubMed

47. Bernstein AD, Klevezal GA. Age determination of Ochotona rutila and Ochotona macrotis. Zool Zhurnal 1965;44:787–9.Search in Google Scholar

48. Harkness JE, Wagner JE. The biology and medicine of rabbits and rodents. Philadelphia: Lea and Febiger, 1989.Search in Google Scholar

49. Weisbroth SH, Flatt RE, Kraus AL. The biology of the laboratory rabbit. New York: Academic Press, 1974.Search in Google Scholar

50. Lebas F, Coudert P, de Rochambeau H, Thebault RG. The rabbit, husbandry, health and production. Rome: Food and Agriculture Organization of the United Nations, 1997.Search in Google Scholar

51. Sengupta P. A small-scale cross-sectional study for the assessment of cardiorespiratory fitness in relation to body composition and morphometric characters in fishermen of Araku Valley, Andhra Pradesh, India. Int J Prev Med 2014;5:557–62.Search in Google Scholar

52. Fagundes DJ, Taha MO. Animal disease model: choices criteria and current animals specimens. Acta Cirur Bras 2004;19:59–65.10.1590/S0102-86502004000100010Search in Google Scholar

53. Adams CE. Reproductive performance of rabbits on a low protein diet. Lab Anim 1983;17:340.10.1258/002367783781062244Search in Google Scholar PubMed

54. Adams CE. Induction of ovulation and A.I. techniques in the rabbit. Vet Rec 1972;1972:194.10.1136/vr.91.8.194Search in Google Scholar

55. Morton DB, Glover TD. Sperm transport in the female rabbit: the effect of inseminate volume and sperm density. J Reprod Fertil 1974;38:139–46.10.1530/jrf.0.0380139Search in Google Scholar PubMed

56. Elkomy AE, Abd El-Hady AM, Elghalid OA. Dietary boron supplementation and its impact on semen characteristics and physiological status of adult male rabbits. Asian J Poultry Sci 2015;9:85.10.3923/ajpsaj.2015.85.96Search in Google Scholar

57. Kilborn SH, Trudel G, Uhthoff H. Review of growth plate closure compared with age at sexual maturity and lifespan in laboratory animals. Contemp Top Lab Anim Sci 2002;41: 21–6.Search in Google Scholar PubMed

Received: 2018-01-05
Accepted: 2018-02-16
Published Online: 2018-04-19
Published in Print: 2018-09-25

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