The active component in cullilawan oil can be synthesized into curcumin analogue product, which has pharmacological activity. The synthesis process by using conventional and microwave methods can produce different isomer products. Different synthesis products and models of animal are used to provide different hepatoprotective effects. The aim of this study was to use the curcumin analogue synthetic products (AKS-k and AKS-m) from cullilawan oil in male mice (Mus musculus L.) liver damage treatment induced by carbon tetrachloride (CCl4). The in vivo method was employed using biochemical of blood and histopathological images of liver cells as indicators. The results showed that the curcumin analogue synthetic product using microwave methods had better pharmacological effects than the conventional method product in terms of the results of blood biochemical analysis and microscopic images of liver cells.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Research funding: This research fund is supported by Directorate of Research and Community Service, The Ministry of Research, Technology, and Higher Education for giving Research Post-Doctoral.
Competing interests: The authors state no conflict of interest.
Ethical approval: Research involving animals complied with all relevant national regulations and institutional policies for the care and use of animals (614/ETIK2019).
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