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Licensed Unlicensed Requires Authentication Published by De Gruyter January 11, 2020

The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension

  • Nursela Hijriani EMAIL logo , Lilik Yusetyani and Didik Hasmono



Hypertension is a cardiovascular disease which has become a major health problem in Indonesia. Left ventricle hypertrophy is one of the cardiac complications of hypertension that is characterized by thickening of the left ventricle and increasing the mass of cardiac muscle.


This study was an experimental study with a posttest group design. Twenty-four mice were divided into four groups. The normal group was given distilled water, the negative control group was given L-NAME 1.75 mg/25 g BW/day, the positive control group was given L-NAME 1.75 mg/25 g BW/day + captopril 0.04875 mg/30 g BW/day, and the adjuvant captopril group was given L-NAME 1.75 mg/25 g BW/day + captopril 0.04875 mg/30 g BW/day + curcuma extract 31.25 mg/30 g BW for 30 days.


The results of one-way analysis of variance (ANOVA) test analysis on the adjuvant treatment of the captopril group revealed no significant effect on cardiac muscle mass (p > 0.05), while the thickness of the left ventricle was significant (p < 0.05).


Captopril-Curcuma group resulted in a decrease of cardiac muscle and the thickness of the left ventricle in male mice with hypertension.


The author thanks the Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga and Pharmacy Departement, Health Science Faculty, University of Muhammadiyah Malang.

  1. Research funding: There is no funding in this research.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval: Research involving animals complied with all relevant national regulations and institutional policies (Animal Research Laboratory of Faculty of Medicine, Universitas Brawijaya, Malang, Idnonesia) for the care and use of animals. The study has passed the ethical clearance from Brawijaya University on 8th July 2015 with No. 370/EC/KEPK/07/2015.


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Received: 2019-09-24
Accepted: 2019-11-29
Published Online: 2020-01-11

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