With the development of infectious diseases, the use of antibiotics is increasing. Amoxicillin is a penicillin class of antibiotics that are widely used today. Compliance with amoxicillin can reduce the risk of microbial resistance. Two fundamental factors that determine patient compliance in antibiotic therapy are the patient's knowledge and attitude towards the antibiotic. In this study, we want to know the effect of knowledge and attitudes of patients on their compliance in using amoxicillin antibiotics.
This study was an observational study with a cross section approach, a purposive sampling method by giving questionnaires to 100 respondents who received amoxicillin in Arjuno Primary Health Care, Klojen District in April 2019. Research variables include knowledge, attitudes, and patient compliance in using amoxicillin antibiotics. Data analysis was performed to determine the effect of knowledge and attitudes of patients on compliance with amoxicillin antibiotic therapy.
The results showed that knowledge significantly influences the complience (sig = 0.00), while attitude does not significantly influence compliance in using amoxicillin antibiotics(sig = 0,136). Knowledge and attitude were known to have a significant effect on compliance with amoxicillin antibiotic therapy (sig = 0.00), the magnitude of the influence of the two variables (R2 = 16.7%).
It can be concluded that the patient's knowledge and attitude influences his compliance to antibiotic therapy.
Authors would like to thank Puskesmas Arjuno Klojen, Malang City providing the opportunity for researchers to conduct study. Also the Faculty of Pharmacy Airlangga, the host of International Joint Symposium of the 8th Asia Pacific Pharmacy Education Network (APPEN) for accepting this manuscript.
Research funding: Independent funding by researchers
Author contributions: All authors ( Liza Pristianty, Vvi Laily Kurniawati, Ika Ratna Hidayati) have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: There are no conflicts of interest with the publication of this article
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: Research involving human subjects complied with all relevant national regulations, institutional policies and is in accordance with the tenets of the Health Research Ethic Committee University of Muhammadiyah Malang (as revised in 2019), and has been approved by the authors’ institutional review board (2019) or equivalent committee. (No.E.5.a/065/KEPK-UMM/IV/2019).
 Radji M. Microbiology. Jakarta: ECG Medical Book, 2011.Search in Google Scholar
 André M, Vernby Å, Berg J, Lundborg CS. A survey of public knowledge and awareness related to antibiotic use and resistance in Sweden. J Antimic Chem 2010;65:1292–6.10.1093/jac/dkq104Search in Google Scholar PubMed
 Grigoryan L, Burgerhof JG, Degener JE, Deschepper R, Lundborg CS, Monnet DL, et al. On behalf of the SAR consortium attitudes, beliefs and knowledge concerning antibiotic use and self-medication: a comparative European study. Pharm Drug Saf 2007;16:1234–43.10.1002/pds.1479Search in Google Scholar
 Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. Pharm Therap 2015;40:277–83.Search in Google Scholar
 RI Ministry of Health (Kemenkes). RI Minister of Health Regulation No. 2406/Menkes/Per/XII/2011 Regarding General Guidelines for the Use of Antibiotics. Jakarta: RI Ministry of Health, 2011:874.Search in Google Scholar
 Glanz K, Rimer BK, Viswanath K. Health behavior and health education, theory, research, and practice, 4th ed. San Francisco: Jossey-Bass A Willey Imprint, 2008.Search in Google Scholar
 UNICEF. Amoxicillin dispersible tablets: product profile, availability and guidance. København: UNICEF, 2013.Search in Google Scholar
 Graves AK, Liwimbi L, Israel LD, Heugten EV, Robinson B, Cahoon CW, et al. Distribution of ten antibiotic resistance genes in e colli isolates from swine manure, lagoon effluent and soli collected from a lagoon waste application field. Folia Microbiol 2011;56:131–7.10.1007/s12223-011-0019-zSearch in Google Scholar PubMed
 Central Statistics Agency (BPS). 2018. https://malangkota.bps.go.id/dynamictable/2019/07/23/35/percentage-population-age-10-years-to-top-in-town-Malang-according-to-highest-education-completed-2005-2018.html. Accessed: 17 September 2018.Search in Google Scholar
 Rahmayanti SN, Tri A. Karakteristik responden dalam penggunaan jaminan kesehatan pada era BPJS di Puskesmas Cisoka Kabupaten Tangerang Januari-Agustus 2015. Jurnal Medicoeticolegal dan Manajemen Rumah Sakit 2017;6:61–5.10.18196/jmmr.6128Search in Google Scholar
 Pristianty L, Fasich F, Wibowo A, Mufarrihah M. The influence of pharmaceutical care to improve the knowledge and attitude of clients by self medication of non-steroidal anti-inflammatory drug (studies in several pharmacies in surabaya-indonesia). Int J Pharm. 2015;5:87–92.Search in Google Scholar
 Whittaker A, Lohm D, Lemoh C, Allen C, Cheng AC, Davis M. Investigating understandings of antibiotics and antimicrobial resistance in diverse ethnic communities in Australia: findings from a qualitative study. Antibiotics (Basel) 2019;8:135.10.3390/antibiotics8030135Search in Google Scholar PubMed PubMed Central
 Yusef D, Babaa AI, Bashaireh AZ, Al-Bawayeh HH, Al-Rijjal K, Nedal M, et al. Knowledge, practices & attitude toward antibiotics use and bacterial resistance in Jordan: a cross-sectional study. Infect Dis Health 2018;23:33–40.10.1016/j.idh.2017.11.001Search in Google Scholar PubMed
 Jifar A, Ayele Y. Assessment of knowledge, attitude, and practice toward antibiotic use among harar city and its surrounding community, Eastern Ethiopia. Interdiscip Perspect Infect Dis 2018;2018:8492740.10.1155/2018/8492740Search in Google Scholar PubMed PubMed Central
 Rogers EM. Diffusion of Innovations, 3rd ed. London: Collier Macmillan Publishing, 1995:163–206.Search in Google Scholar
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