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Licensed Unlicensed Requires Authentication Published by De Gruyter February 12, 2020

Knowledge and attitude: two fundamental factors that determine patient compliance in antibiotic therapy

  • Liza Pristianty EMAIL logo , Vivi Laily Kurniati and Ika Ratna Hidayati



With the development of infectious diseases, the use of antibiotics is increasing. Amoxicillin is a penicillin class of antibiotics that are widely used today. Compliance with amoxicillin can reduce the risk of microbial resistance. Two fundamental factors that determine patient compliance in antibiotic therapy are the patient's knowledge and attitude towards the antibiotic. In this study, we want to know the effect of knowledge and attitudes of patients on their compliance in using amoxicillin antibiotics.


This study was an observational study with a cross section approach, a purposive sampling method by giving questionnaires to 100 respondents who received amoxicillin in Arjuno Primary Health Care, Klojen District in April 2019. Research variables include knowledge, attitudes, and patient compliance in using amoxicillin antibiotics. Data analysis was performed to determine the effect of knowledge and attitudes of patients on compliance with amoxicillin antibiotic therapy.


The results showed that knowledge significantly influences the complience (sig = 0.00), while attitude does not significantly influence compliance in using amoxicillin antibiotics(sig = 0,136). Knowledge and attitude were known to have a significant effect on compliance with amoxicillin antibiotic therapy (sig = 0.00), the magnitude of the influence of the two variables (R2 = 16.7%).


It can be concluded that the patient's knowledge and attitude influences his compliance to antibiotic therapy.


Authors would like to thank Puskesmas Arjuno Klojen, Malang City providing the opportunity for researchers to conduct study. Also the Faculty of Pharmacy Airlangga, the host of International Joint Symposium of the 8th Asia Pacific Pharmacy Education Network (APPEN) for accepting this manuscript.

  1. Research funding: Independent funding by researchers

  2. Author contributions: All authors ( Liza Pristianty, Vvi Laily Kurniawati, Ika Ratna Hidayati) have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: There are no conflicts of interest with the publication of this article

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: Research involving human subjects complied with all relevant national regulations, institutional policies and is in accordance with the tenets of the Health Research Ethic Committee University of Muhammadiyah Malang (as revised in 2019), and has been approved by the authors’ institutional review board (2019) or equivalent committee. (No.E.5.a/065/KEPK-UMM/IV/2019).


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Received: 2019-10-31
Accepted: 2019-11-20
Published Online: 2020-02-12

© 2019 Walter de Gruyter GmbH, Berlin/Boston

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