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Licensed Unlicensed Requires Authentication Published by De Gruyter July 1, 2013

The use of an anti-inflammatory supplement in patients with chronic kidney disease

Jennifer J. Moreillon, Rodney G. Bowden, Erika Deike, Jackson Griggs, Ron Wilson, Brian Shelmadine, Matt Cooke and Alexander Beaujean

Abstract

Chronic kidney disease (CKD) is characterized by a continuous reduction in kidney function, increased inflammation, and reduced antioxidant capacity. The objective of this study was to assess the effects of a herbal supplement on systemic inflammation and antioxidant status in non-dialysis CKD patients. Sixteen patients with CKD (56.0±16.0 yrs, 171.4±11.9 cm, 99.3±20.2 kg) were randomly chosen to receive a herbal supplement composed of Curcuma longa and Boswellia serrata, or placebo. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), and serum C-reactive protein (CRP) were measured at baseline and 8 weeks. Baseline data demonstrated elevated inflammation and low antioxidant levels. A significant time effect (p=0.03) and time x compliance interaction effect (p=0.04) were observed for IL-6. No significant differences were observed for any other variables. This study demonstrates that mild and moderate CKD is associated with chronic inflammation and low antioxidant activity. Systemic inflammation and impaired antioxidant status may be greater in CKD populations with multiple comorbidities. Curcumin and Boswellia serrata are safe and tolerable and helped to improve the levels of an inflammatory cytokine.

Acknowledgments

The authors thank the entire staff of the Family Health Center for making this study possible, especially CraShanta Evans, Toni Marshall, and Linda Garcia. The supplements used in this project were donated by Life Extension, Inc.

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Received: 2011-09-07
Accepted: 2012-05-17
Published Online: 2013-07-01

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