Accessible Requires Authentication Published by De Gruyter June 13, 2014

Hypoglycemic effect of Rhizophora mucronata in streptozotocin induced diabetic rats

Awanish K. Pandey, Prem P. Gupta and Vijay K. Lal


Rhizophora mucronata, plant of Mangroove family, found on the coastal region of India and used in treatment of various diseases. Different parts of plants are used in treatment of diabetes as folkloric medicine. The present study was designed to evaluate the hypoglycemic effect of hydro-alcoholic extract of R. mucronata. Streptozotocin (STZ)-induced diabetic rats were treated with RME (100 mg/kg and 200 mg/kg) and glibenclamide (0.5 mg/kg). Blood glucose levels were evaluated for the acute and sub-acute studies and body weight of rats were also monitored. All the treatments showed the highly significant (p<0.01) hypoglycemic effect in both the acute and the sub-acute studies. RME and glibenclamide treated rats were maintained the body weight during the study period while as the body weight of diabetic rats had gone down. The result of this study scientifically proved the hypoglycemic folkloric use of leaves of R. mucronata in treatment of diabetes.


1. BaileyCJ. Potential new treatments for type 2 diabetes. Trends Pharmacol Sci2000;21:25965. Search in Google Scholar

2. AragaoDM, GuarizeL, LaniniJ, Da CostaJC, GarciaRM, ScioE. Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats. J Ethnopharmacol2010;128:62933. Search in Google Scholar

3. BirariRB, BhutaniKK. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov Today2007;12:87989. Search in Google Scholar

4. MetcalfeA, WilliamsJ, McChesneyJ, PattenSB, JetteN. Use of complementary and alternative medicine by those with a chronic disease and the general population–results of a national population based survey. BMC Complement Altern Med2010;10:58. Search in Google Scholar

5. FernandesNP, LagishettyCV, PandaVS, NaikSR. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern Med2007;7:29. Search in Google Scholar

6. MukherjeePK, VenkateshP, PonnusankarS. Ethnopharmacology and integrative medicine – let the history tell the future. J Ayurveda Integr Med2010;1:1009. Search in Google Scholar

7. RaoNK, NammiS. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complement Altern Med2006;6:17. Search in Google Scholar

8. JayakarB, SureshB. Anti-hyperglycemic and hypoglycemic effect of Aporosa lindleyana in normal and alloxan induced diabetic rats. J Ethnopharmacol2003;84:2479. Search in Google Scholar

9. Kameswara RaoB, RajasekharMD, SreelathaA, ApparaoC. Treatment of diabetes mellitus: plant drugs vs. Oral hypoglycemic agents and insulin, chapter 13. In: Recent progress in medicinal plants. Biopharmaceuticals, vol. 14. Studium Press, 2006:27996. Search in Google Scholar

10. MukherjeePK, MaitiK, MukherjeeK, HoughtonPJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol2006;106:128. Search in Google Scholar

11. World Health Organization. The WHO experts committee on diabetes mellitus. Technical report series. Geneva: World Health Organization, 1980. Search in Google Scholar

12. AnjaneyuluAS, AnjaneyuluV, RaoVL. New beyerane and isopimarane diterpenoids from Rhizophora mucronata. J Asian Nat Prod Res2002;4:5361. Search in Google Scholar

13. LaphookhieoS, KaralaiC, PonglimanontC. New sesquiterpenoid and triterpenoids from the fruits of Rhizophora mucronata. Chem Pharm Bull2004;52:8835. Search in Google Scholar

14. CacéresA, LópezBR, JuarezX, del AguilaJ, GarcíaS. Plants used in Guatemala for the treatment of dermatophytic infections. 2. Evaluation of antifungal activity of seven American plants. J Ethnopharmacol1993;40:20713. Search in Google Scholar

15. MelchorG, ArmenterosM, FernándezO, LinaresE, FragasI. Antibacterial activity of Rhizophora mangle bark. Fitoterapia2001;17:68991. Search in Google Scholar

16. MarreroE, SánchezJ, de ArmasE, EscobarA, MelchorG, AbadMJ, et al. COX-2 and sPLA2 inhibitory activity of aqueous extract and polyphenols of Rhizophora mangle (red mangrove). Fitoterapia2006;77:31315. Search in Google Scholar

17. BerenguerB, SánchezLM, QuílezA, López-BarreiroM, de HaroO, GálvezJ, et al. Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers. J Ethnopharmacol2006;103:194200. Search in Google Scholar

18. FernándezO, CapdevilaJZ, DallaG, MelchorG. Efficacy of Rhizophora mangle aqueous bark extract in the healing of open surgical wounds. Fitoterapia2002;73:5648. Search in Google Scholar

19. VijayavelK, AnbuselvamC, BalasubramanianMP. Free radical scavenging activity of the marine mangrove Rhizophora apiculata bark extract with reference to naphthalene induced mitochondrial dysfunction. Chem Biol Interact2006;163:1705. Search in Google Scholar

20. MatsuiT, TanakaT, TamuraS, ToshimaA, MiyataY, TanakaK, et al. Alpha-glucosidase inhibitory profile of catechins and theaflavins. J Agric Food Chem2007;55:99105. Search in Google Scholar

21. KuriyanR, RajendranR, BantwalG, KurpadAV. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diab care2008;31:21620. Search in Google Scholar

22. MarlesRJ, FarnsworthNR. Antidiabetic plants and their active constituents. Phytomedicine1995;2:13789. Search in Google Scholar

23. ChanHT, SallehMN. Traditional uses of the mangrove ecosystems. Mangrove ecosystems: occasional papers no. 1. New Delhi: UNESCO, 1987:31. Search in Google Scholar

24. FieldC. Journeys amongst mangroves. International Society for Mangrove Ecosystems, Okinawa, Japan. Hong Kong: South China Printing Co., 1995:140. Search in Google Scholar

25. RolletB. Bibliography on mangrove research 1600–1975. Paris and London: UNESCO and Information Retrieval Ltd., 1981:479. Search in Google Scholar

26. TomlinsonPB. The botany of mangroves. Cambridge: Cambridge University Press, 1986:41314. Search in Google Scholar

27. VannucciM. The mangroves and us. New Delhi: Indian Association for the Advancement of Science, 1989:203. Search in Google Scholar

28. DukeJA, WainKK. Medicinal plants of the world. Computer index with more than 85,000 entries, 1981:3. Search in Google Scholar

29. BrahmachariG. Bio-flavonoids with promising antidiabetic potentials: a critical survey. Opportunity, challenge and scope of natural products in medicinal chemistry, 2011:187212. Search in Google Scholar

30. IvorraMD, D’OconMP, PayaM, VillarA. Antihyperglycemic and insulin-releasing effects of beta-sitosterol 3-beta-D-glucoside and its aglycone, beta-sitosterol. Arch Int Pharmacodyn Ther2011;296:22431. Search in Google Scholar

31. BalamuruganR, DuraipandiyanV, IgnacimuthuS. Antidiabetic activity of γ-sitosterol isolated from Lippia nodiflora L. in streptozotocin induced diabetic rats. Eur J Pharmacol2011;667:41018. Search in Google Scholar

Received: 2012-12-20
Accepted: 2014-5-19
Published Online: 2014-6-13
Published in Print: 2014-9-1

©2014 by De Gruyter