Accessible Requires Authentication Published by De Gruyter June 12, 2013

Hericium erinaceus: an edible mushroom with medicinal values

Md. Asaduzzaman Khan, Mousumi Tania, Rui Liu and Mohammad Mijanur Rahman

Abstract

Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion’s Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in some physiologically important components, especially β-glucan polysaccharides, which are responsible for anti-cancer, immuno-modulating, hypolipidemic, antioxidant and neuro-protective activities of this mushroom. H. erinaceus has also been reported to have anti-microbial, anti-hypertensive, anti-diabetic, wound healing properties among other therapeutic potentials. This review article has overviewed the recent advances in the research and study on H. erinaceus and discussed the potential health beneficial activities of this mushroom, with the recognition of bioactive compounds responsible for these medicinal properties.

References

1. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007;70:461–77. Search in Google Scholar

2. Kaul TN. Biology and conservation of mushrooms. New Delhi: Oxford & IBH Publishing Co. Pvt. Ltd, 2001:117–45. Search in Google Scholar

3. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol 2009;10:717–42. Search in Google Scholar

4. Bisen PS, Baghel RK, Sanodiya BS, Thakur GS, Prasad GB. Lentinus edodes: a macrofungus with pharmacological activities. Curr Med Chem 2010;17:2419–30. Search in Google Scholar

5. Khan MA, Tania M, Zhang DZ, Chen HC. Cordyceps mushroom: a potent anticancer nutraceutical. Open Nutra J 2010;3:179–83. Search in Google Scholar

6. Wani BA, Bodha RH, Wani AH. Nutritional and medicinal importance of mushrooms. J Med Plants Res 2010;4:2598–604. Search in Google Scholar

7. Lindequist U, Rausch R, Füssel A, Hanssen HP. Higher fungi in traditional and modern medicine. Med Monatsschr Pharm 2010;33:40–8. Search in Google Scholar

8. Khan MA, Tania M. Nutritional and medicinal importance of Pleurotus mushrooms: an overview. Food Rev Int 2012;28:313–29. Search in Google Scholar

9. Yang BK, Park JB, Song CH. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus. Biosci Biotechnol Biochem 2003;67:1292–8. Search in Google Scholar

10. Hiwatashi K, Kosaka Y, Suzuki N, Hata K, Mukaiyama T, Sakamoto K, et al. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet. Biosci Biotechnol Biochem 2010;74:1447–51. Search in Google Scholar

11. Wang JC, Hu SH, Su CH, Lee TM. Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp. Kaohsiung J Med Sci 2001;17:461–7. Search in Google Scholar

12. Liu C, Gao P, Qian J, Yan W. Immunological study on the antitumor effects of fungus polysaccharides compounds. Wei Sheng Yan Jiu 2000;29:178–80. Search in Google Scholar

13. Lee JS, Min KM, Cho JY, Hong EK. Study of macrophageactivation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. J Microbiol Biotechnol 2009;19:951–9. Search in Google Scholar

14. Lee JS, Hong EK. Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. Cancer Lett 2010;297:144–54. Search in Google Scholar

15. Kim SP, Kang MY, Kim JH, Nam SH, Friedman M. Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. J Agric Food Chem 2011;59:9861–9. Search in Google Scholar

16. Kim SP, Kang MY, Choi YH, Kim JH, Nam SH, Friedman M. Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Food Funct 2011;2:348–56. Search in Google Scholar

17. Gu YH, Belury MA. Selective induction of apoptosis in murine skin carcinoma cells (CH72) by an ethanol extract of Lentinula edodes. Cancer Lett 2005;220:21–8. Search in Google Scholar

18. Choi WS, Kim CJ, Park BS, Lee SE, Takeoka GR, Kim DG, et al. Inhibitory effect on proliferation of vascular smooth muscle cells and protective effect on CCl(4)-induced hepatic damage of HEAI extract. J Ethnopharmacol 2005;100:176–9. Search in Google Scholar

19. Kim YO, Lee SW, Oh CH, Rhee YH. Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages. Immunopharmacol Immunotoxicol 2012;34:504–12. Search in Google Scholar

20. Mori K, Kikuchi H, Obara Y, Iwashita M, Azumi Y, Kinugasa S, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine 2010;17:1082–5. Search in Google Scholar

21. Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull 2008;31:1727–32. Search in Google Scholar

22. Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effectsof Hericium erinaceus on amyloid β(25–35) peptide-induced learning and memory deficits in mice. Biomed Res 2011;32: 67–72. Search in Google Scholar

23. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res 2010;31:231–7. Search in Google Scholar

24. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res 2009;23:367–72. Search in Google Scholar

25. Wong KH, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, et al. Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med 2011;2011:580752. Search in Google Scholar

26. Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh 2003;49:38–45. Search in Google Scholar

27. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci 1993;90:7915–22. Search in Google Scholar

28. Khan MA, Tania M, Zhang DZ, Chen HC. Antioxidant enzymes and cancer. Chin J Cancer Res 2010;22:87–92. Search in Google Scholar

29. Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF. Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evid Based Complement Alternat Med 2012;2012:464238. Search in Google Scholar

30. Wong KH, Sabaratnam V, Abdullah N, Kuppusamy UR, Naidu M. Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus (Bull.:Fr.) Pers. extracts. Food Technol Biotechnol 2009;47: 47–55. Search in Google Scholar

31. Han ZH, Ye JM, Wang GF. Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Int J Biol Macromol 2013;52:66–71. Search in Google Scholar

32. Zhang Z, Lv G, Pan H, Pandey A, He W, Fan L. Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey. Int J Biol Macromol 2012;51:1140–6. Search in Google Scholar

33. Xu CP, Liu WW, Liu FX, Chen SS, Liao FQ, Xu Z, et al. A double-blind study of effectiveness of Hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. Chin Med J 1985;98:455–6. Search in Google Scholar

34. Abdulla MA, Fard AA, Sabaratnam V, Wong KH, Kuppusamy UR, Abdullah N, et al. Potential activity of aqueous extract of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. Int J Med Mushrooms 2011;13:33–9. Search in Google Scholar

35. Wang JC, Hu SH, Wang JT, Chen KS, Chia YC. Hypoglycemic effect of extract of Hericium erinaceus. J Sci Food Agric 2005;85:641–6. Search in Google Scholar

36. Jia LM, Liu L, Dong Q, Fang JN. Structural investigation of a novel rhamnoglucogalactan isolated from the fruiting bodies of the fungus Hericium erinaceus. Carbohydr Res 2004;339:2667–71. Search in Google Scholar

37. Zhang AQ, Zhang JS, Tang QJ, Jia W, Yang Y, Liu YF, et al. Structural elucidation of a novel fucogalactan that contains 3-O-methyl rhamnose isolated from the fruiting bodies of the fungus, Hericium erinaceus. Carbohydr Res 2006;341:645–9. Search in Google Scholar

38. Qian FG, Xu GY, Du SJ, Li MH. Isolation and identification of two new pyrone compounds from the culture of Herictum erinaceus. Yao Xue Xue Bao 1990;25:522–5. Search in Google Scholar

Received: 2013-01-09
Accepted: 2013-04-29
Published Online: 2013-06-12

©2013 by Walter de Gruyter Berlin / Boston