Accessible Requires Authentication Published by De Gruyter July 19, 2014

Antiplasmodial potential of homeopathic drugs Chelidonium and nosode against Plasmodium berghei infection

Upma Bagai and Neha S. Walter

Abstract

Background: Malaria remains a major global health concern in developing regions of the world. Homeopathy, a holistic system of medicine, has a lot to offer in protecting against malaria.

Methods: In the present study, antimalarial efficacy of combination of two homeopathic drugs Chelidonium 30 and nosode 30 has been evaluated in vivo against Plasmodium berghei (P. berghei) infection using Peters 4-day test. Biochemical assays have been performed to assess the levels of hepatic and renal function biomarkers upon drug treatment using diagnostic kits.

Results: The combination of the drugs demonstrated considerable in vivo antimalarial activity with chemosuppression of 91.45% on day 7. The combination also significantly (p<0.0005) enhanced the mean survival time of mice which was calculated to be 22.5±6.31 days, whereas it was 8.55±0.83 days in infected control. The increase in levels of the liver function marker enzymes tested in serum of treated mice were significantly less (p<0.0005) than those observed in infected control on day 10. The serum urea and creatinine used for assessment of renal sufficiency were slightly elevated above normal, but were statistically significant (p<0.0005) as compared to infected control.

Conclusions: The study establishes the effectiveness of the combination against P. berghei in vivo along with the safety of the drugs to the liver and kidney functions of the host.

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Received: 2013-2-11
Accepted: 2014-5-20
Published Online: 2014-7-19
Published in Print: 2014-9-1

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