Accessible Unlicensed Requires Authentication Published by De Gruyter March 12, 2015

Bovine colostrum: an emerging nutraceutical

Siddhi Bagwe, Leo J.P. Tharappel, Ginpreet Kaur and Harpal S. Buttar

Abstract

Nutraceutical, a term combining the words “nutrition” and “pharmaceuticals”, is a food or food product that provides health benefits as an adjuvant or alternative therapy, including the treatment and prevention of infectious diseases in children and adults. There is emerging evidence that bovine colostrum (BC) may be one of the promising nutraceuticals which can prevent or mitigate various diseases in newborns and adults. Immunity-related disorders are one of the leading causes of mortality in the world. BC is rich in immunity, growth and antimicrobial factors, which promote tissue growth and the maturation of digestive tract and immune function in neonatal animals and humans. The immunoglobulins and lactoferrin present in colostrum are known to build natural immunity in newborns which helps to reduce the mortality rate in this population. Also, the side-effect profile of colostrum proteins and possible lactose intolerance is relatively less in comparison with milk. In general, BC is considered safe and well tolerated. Since colostrum has several important nutritional constituents, well-designed, double-blind, placebo-controlled studies with colostrum products should be conducted to widen its therapeutic use. The objectives of this review are to create awareness about the nutraceutical properties of colostrum and to discuss the various ongoing alternative treatments of colostrum and its active ingredients as well as to address colostrum’s future nutraceutical and therapeutic implications in humans.

Acknowledgments

The authors would like to thank SPPSPTM NMIMS for providing the facilities utilized in this review.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. GrivennikovSI, SergeiI, GretenFR, KarinM. Immunity, inflammation, and cancer. Cell2010;140:88399.Search in Google Scholar

2. ChopraI, RobertsM. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev2001;65:23260.Search in Google Scholar

3. DaviesJ. Inactivation of antibiotics and the dissemination of resistance genes. Science1994;264:37582.Search in Google Scholar

4. BrownMR, AllisonDG, GilbertP. Resistance of bacterial biofilms to antibiotics a growth-rate related effect?. J Antimicrob Chemother1988;22:77780.Search in Google Scholar

5. NeuHC. The crisis in antibiotic resistance. Science1992;257:106473.Search in Google Scholar

6. DemerecM. Origin of bacterial resistance to antibiotics. J Bacteriol1948;56:6374.Search in Google Scholar

7. PakkanenR, AaltoJ. Growth factors and antimicrobial factors in bovine colostrum. Int Dairy J1997;7:28597.Search in Google Scholar

8. OgraSS, OgraPL. Immunological aspects of human colostrum and milk. J Pediatr1978;92:5505.Search in Google Scholar

9. van HooijdonkAC, KussendragerKD, SteijnsJM. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. Br J Nutr2000;84:S12734.Search in Google Scholar

10. TokuyamaH, TokuyamaY, MigitaS. Isolation of two new proteins from bovine colostrum which stimulate epidermal growth factor-dependent colony formation of NRK-49f cells. Growth Factors1990;3:10514.Search in Google Scholar

11. StelwagenK, CarpenterE, HaighB, HodgkinsonA, WheelerTT. Immune components of bovine colostrum and milk. J Anim Sci2009;87:39.Search in Google Scholar

12. ShahNP. Effects of milk-derived bioactives: an overview. Br J Nutr2000;84:310.Search in Google Scholar

13. de AlmeidaMF, DraqueCM. Neonatal jaundice and breastfeeding. Neoreviews2007;8:e2828.Search in Google Scholar

14. CohenSM. Jaundice in the full-term newborn. Pediatr Nurs2006;32:2028.Search in Google Scholar

15. MorrisJA, WrayC, SojkaWJ. Passive protection of lambs against enteropathogenic Escherichia coli: role of antibodies in serum and colostrums. J Med Microbiol1980;13:26571.Search in Google Scholar

16. EbinaT, OhtaM, KanamaruY, Yamamoto-OsumiY, BabaK. Passive immunizations of suckling mice and infants with bovine colostrum containing antibodies to human rotavirus. J Med Virol1992;38:11723.Search in Google Scholar

17. MajumdarAS, GhoseAC. Protective properties of anti-cholera antibodies in human colostrum. Infect Immun1982;36:9625.Search in Google Scholar

18. StephanW, DichtelmullerH, LissnerR. Antibodies from colostrum in oral immunotherapy. J Clin Chem Clin Biochem1990;28:1923.Search in Google Scholar

19. HurleyWL, TheilPK. Perspectives on immunoglobulins in colostrum and milk. Nutrients2011;3:44274.Search in Google Scholar

20. SarkerSA, CasswallTH, MahalanabisD, AlamNH, AlbertMJ, BrüssowH, et al. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrums. Pediatr Infect Dis J1998;17:114954.Search in Google Scholar

21. ElfstrandL, Lindmark-MånssonH, PaulssonM, NybergL, ÅkessonB. Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing. Int Dairy J2002;12:87987.Search in Google Scholar

22. SabinAB, FieldsteelAH. Antipoliomyelitic activity of human and bovine colostrum and milk. Pediatrics1962;29:10515.Search in Google Scholar

23. NitschA, NitschFP. The clinical use of bovine colostrum. J Orthomol Med1998;13:11018.Search in Google Scholar

24. AfzalA, MahmoodMS, HussainI, AkhtarM. Adulteration and microbiological quality of milk (a review). Pak J Nutr2011;10:1195202.Search in Google Scholar

25. KorhonenH, Pihlanto-LeppälaA, RantamäkiP, TupaselaT. Impact of processing on bioactive proteins and peptides. Trends Food Sci Tech1998;9:30719.Search in Google Scholar

26. JennyBF, HodgeSE, O’DellGD, EllersJE. Influence of colostrum preservation and sodium bicarbonate on performance of dairy calves. J Dairy Sci1984;67:31318.Search in Google Scholar

27. FoleyJA, OtterbyDE. Availability, storage, treatment, composition, and feeding value of surplus colostrum: a review. J Dairy Sci1978;61:103360.Search in Google Scholar

28. GoddenS, McMartinS, FeirtagJ, StabelJ, BeyR, GoyalS, et al. Heat-treatment of bovine colostrum. II: effects of heating duration on pathogen viability and immunoglobulin G. J Dairy Sci2006;89:347683.Search in Google Scholar

29. SethR, DasA. Colostrum powder and its health benefits. In: SharmaR, MannB, editors. Chemical analysis of value added dairy products and their quality assurance. Karnal, Haryana, India: Division of Dairy Chemistry, National Dairy Research Institute, 2011:5967.Search in Google Scholar

30. ThompsonJ, RulofsonF, HansenD. Artificial rearing of lambs on milk replacer diets. Available at . Accessed:29 Aug 2014.Search in Google Scholar

31. Colostrum. Available at: . Accessed:29 Aug 2014.Search in Google Scholar

32. ChristensenRD. Infant formula compositions for neonates lacking mother’s own colostrum and method of making. US 20100183769 A1 (2010).Search in Google Scholar

33. MacyIG. Composition of human colostrum and milk. Am J Dis Child1949;78:589603.Search in Google Scholar

34. JennessR. The composition of human milk. Semin Perinatol1979;3:22539.Search in Google Scholar

35. EddlemanH. Composition of Human, Cow and Goat Milks (B120A). Available at: . Accessed:30 Aug 2014.Search in Google Scholar

36. AhmadS, AnjumFM, HumaN, SameenA, ZahoorT. Composition and physico-chemical characteristics of buffalo milk with particular emphasis on lipids, proteins, minerals, enzymes and vitamins. J Anim Plant Sci2013;23:6274.Search in Google Scholar

37. HenryKM, KonSK. A note on the vitamin D content of cow’s colostrum. Biochem J1937;31:2199201.Search in Google Scholar

38. HaroonY, ShearerMJ, RahimS, GunnWG, McEneryG, BarkhanP. The content of phylloquinone (vitamin K1) in human milk, cow’s milk and infant formula foods determined by high-performance liquid chromatography. J Nutr1982;112:110517.Search in Google Scholar

39. APS BioGroup. Available at: . Accessed:30 Aug 2014.Search in Google Scholar

40. Biostrum Nutritech Pvt Ltd. Available at: . Accessed:30 Aug 2014.Search in Google Scholar

41. Mt. Capra Wholefood Nutritionals. Available at: . Accessed:30 Aug 2014.Search in Google Scholar

42. BachJF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med2002;347:91120.Search in Google Scholar

43. KeechA. Novel immunologically active peptide fragments of a proline-rich polypeptide isolated from colostral mammalian fluids for treatment of viral and non-viral diseases or diseased conditions. US 20070212367 A1 (2007).Search in Google Scholar

44. RonaZP. Bovine colostrum emerges as immunity modulator. Am J Nat Med1998;5:1923.Search in Google Scholar

45. KaurG, SomaiyaR, WasimM, ButtarHS. Cardioprotective effects of bovine colostrum against isoproterenol-induced myocardial infarction in rats. J Pharmacol Toxicol2014;9:3745.Search in Google Scholar

46. KwonOY, LeeJS, ChoiHS, HongHP, JangK-H, PaekJH, et al. Antioxidant and anticytokine effects of bovine colostrum in intestinal ischemia/reperfusion injured rat model. Food Sci Biotechnol2010;19:1295301.Search in Google Scholar

47. UndaleVR, DesaiSS, SangamnerkarSK, UpasaniCD. Neuroprotective effect of cow colostrum and tetramethylpyrazine against global cerebral ischemia reperfusion injury. Int J Nutr Pharmacol Neurol Dis2012;2:11120.Search in Google Scholar

48. ChoiHS, KoYG, LeeJS, KwonOY, KimS-K, CheongC, et al. Neuroprotective effects of consuming bovine colostrum after focal brain ischemia/reperfusion injury in rat model. Nutr Res Pract2010;4:196202.Search in Google Scholar

49. KimSE, KoIG, ShinMS, KimCJ, KoYG, ChoHJ. Neuroprotective effects of bovine colostrum on intracerebral haemorrhage-induced apoptotic neuronal cell death in rats. Neural Regen Res2012;7:171521.Search in Google Scholar

50. RatheM, MullerK, SangildPT, HusbyS. Clinical applications of bovine colostrum therapy: a systematic review. Nutr Rev2014;72:23754.Search in Google Scholar

51. DavidsonGP, WhytePB, DanielsE, FranklinK, NunanH, McCloudPI, et al. Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus. Lancet1989;334:70912.Search in Google Scholar

52. MitraAK, MahalanabisD, AshrafH, UnicombL, EeckelsR, TziporiS. Hyperimmune cow colostrum reduces diarrhoea Due To rotavirus: a double-blind, controlled clinical trial. Acta Paediatr1995;84:9961001.Search in Google Scholar

53. InagakiM, MuranishiH, YamadaK, KakehiK, UchidaK, SuzukiT, et al. Bovine κ-casein inhibits human rotavirus (HRV) infection via direct binding of glycans to HRV. J Dairy Sci2014;97:265361.Search in Google Scholar

54. GunaydinG, ZhangR, HammarstromL, MarcotteH. Engineered Lactobacillus rhamnosus GG expressing IgG-binding domains of protein G: capture of hyperimmune bovine colostrum antibodies and protection against diarrhea in a mouse pup rotavirus infection model. Vaccine2014;32:4707.Search in Google Scholar

55. TziporiS, RobertonD, ChapmanC. Remission of diarrhea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrum. Br Med J (Clin Res Ed)1986;296:12767.Search in Google Scholar

56. PanY, LeeA, WanJ, CoventryMJ, MichalskiWP, ShiellB, et al. Antiviral properties of milk proteins and peptides. Int Dairy J2006;16:125261.Search in Google Scholar

57. PatirogluT, KondolotM. The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency. Clin Respir J2013;7:216.Search in Google Scholar

58. WongEB, MalletJF, DuarteJ, MatarC, RitaBW. Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4. Nutr Res2014;34:31825.Search in Google Scholar

59. Cairangzhuoma, YamamotoM, MuranishiH, InagakiM, UchidaK, YamashitaK, et al. Skimmed, sterilized and concentrated bovine late colostrum promotes both prevention and recovery from intestinal tissue damage in mice. J Dairy Sci2013;96:134755.Search in Google Scholar

60. UchidaK, HirutaN, YamaguchiH, YamashitaK, FujimuraK, YasuiH. Augmentation of cellular immunity and protection against influenza virus infection by bovine late colostrum in mice. Nutrition2012;28:4426.Search in Google Scholar

61. NgWC, WongV, MullerB, RawlinG, BrownLE. Prevention and treatment of influenza with hyperimmune bovine colostrum antibody. PLoS ONE2010;5:e13622. doi:10.1371/journal.pone.0013622.Search in Google Scholar

62. KimJH, JungWS, ChoiNJ, KimDO, ShinDH, KimYJ. Health-promoting effects of bovine colostrum in type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketones. J Nutr Biochem2009;20:298303.Search in Google Scholar

63. Bovine colostrum. Healthline.com. Available at: . Accessed 21 Jan 2014.Search in Google Scholar

64. AntonioJ, SandersMS, Van GammerenD. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition2001;17: 2437.Search in Google Scholar

65. MeroA, KahkonenJ, NykanenT, ParviainenT, JokinenenI, TakalaT, et al. IGF-I, IgA and IgG responses to bovine colostrum supplementation during training. J Appl Physiol2002;93:7329.Search in Google Scholar

66. JonesAW, CameronSJ, ThatcherR, BeecroftMS, MurLA, DavisonG. Effects of bovine colostrum supplementation on upper respiratory illness in active males. Brain Behav Immun2014;39:194203.Search in Google Scholar

67. GodhiaML, PatelN. Colostrum – its composition, benefits as a nutraceutical: A review. Curr Res Nutr Food Sci2013;1:3747.Search in Google Scholar

68. MarchbankT, DavisonG, OakesJR, GhateiMA, PattersonM, MoyerMP, et al. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol2011;300:G47784.Search in Google Scholar

69. ShingCM, HunterDC, StevensonLM. Bovine colostrum supplementation and exercise performance: potential mechanisms. Sports Med2009;39:103354.Search in Google Scholar

70. DoillonCJ, LehanceF, BordeleauLJ, Laplante‐CampbellMP, DrouinR. Modulatory effect of a complex fraction derived from colostrum on fibroblast contractibility and consequences on repair tissue. Int Wound J2011;8:28090.Search in Google Scholar

71. TakayamaY, KitsunaiK, MizumachiK. Factors in bovine colostrum that enhance the migration of human fibroblasts in type I collagen gels. Biosci Biotechnol Biochem2001;65:27769.Search in Google Scholar

72. AaltoJU, JalkanenMT, JalonenHG, KanttinenAP, LaatoMK, PakkanenRA. Method for the improvement of wound healing and compositions therefore. WO1995000155 A1 (1995).Search in Google Scholar

73. PlayfordR, FloydD, MacdonaldC, CalnanD, AdenekanR, JohnsonW, et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut1999;44:6538.Search in Google Scholar

74. MurataM, SatohT, WakabayashiH, YamauchiK, AbeF, NomuraY. Oral administration of bovine lactoferrin attenuates ultraviolet B-induced skin photodamage in hairless mice. J Dairy Sci2013;97:6518.Search in Google Scholar

75. FassanoA. Leaky gut and autoimmune diseases. Clin Rev Allergy Immunol2012;42:718.Search in Google Scholar

76. MaesM, KuberaM, LeunisJC. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative Enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuroendocrinol Lett2008;29:11724.Search in Google Scholar

77. What is colostrum good for? Center for Nutritional Research. Available at: . Accessed 21 Jan. 2014.Search in Google Scholar

78. BolkeE, JehlePM, HausmannF, DaublerA, WiedeckH, SteinbachG, et al. Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery. Shock2002;17:912.Search in Google Scholar

79. ThapaBR. Health factors in colostrum. Ind J Pediatr2005;72:57981.Search in Google Scholar

80. BodammerP, KerkhoffC, MaletzkiC, LamprechtG. Bovine colostrums increases pore-forming claudin-2 protein expression but paradoxically not ion permeability possibly by a change of the intestinal cytokine milieu. PLoS ONE2013;8:e64210. doi:10.1371/journal.pone.0064210.Search in Google Scholar

81. RosenthalR, MilatzS, KrugSM, OelrichB, SchulzkeJD, AmashehS, et al. Claudin-2, a component of the tight junction, forms a paracellular water channel. J Cell Sci2010;123:191321.Search in Google Scholar

82. JahantighM, AtyabiN, PourkabirM, Jebelli JavanA, AfshariM. The effect of dietary bovine colostrum supplementation on serum malondialdehyde levels and antioxidant activity in alloxan-induced diabetic rats. Int J Vet Res2011;5:637.Search in Google Scholar

83. PanD, LiuH. Preventive effect of ordinary and hyperimmune bovine colostrums on mice diabetes induced by alloxan. Afr J Biotechnol2008;7:436975.Search in Google Scholar

84. De ClercqE. Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections. J Med Chem1995;38:2491517.Search in Google Scholar

85. WirtDP, AdkinsLT, PalkowetzKH, SchmalstiegFC, GoldmanAS. Activated and memory T lymphocytes in human milk. Cytometry1992;13:28290.Search in Google Scholar

86. KramskiM, CenterRJ, WheatleyAK, JacobsonJC, AlexanderMR, RawlinG, et al. Hyperimmune bovine colostrum as a low-cost, large-scale source of antibodies with broad neutralizing activity for HIV-1 envelope with potential use in microbicides. Antimicrob Agents Chemother2012;56:431019.Search in Google Scholar

87. KanwarJR, HaggartyNW, PalmanoKP, KrissansenGW. Methods of immune or haematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer. US20090202574 A1 (2009).Search in Google Scholar

88. HarmsenMC, SwartPJ, de BéthuneMP, PauwelsR, ClercqE, TheTH, et al. Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. J Infect Dis1995;172:3808.Search in Google Scholar

Received: 2014-6-20
Accepted: 2015-1-29
Published Online: 2015-3-12
Published in Print: 2015-9-1

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