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Licensed Unlicensed Requires Authentication Published by De Gruyter April 7, 2015

The effect of Terminalia chebula extract vs. silver sulfadiazine on burn wounds in rats

  • Ebrahim Nasiri , Seyed Jalal Hosseinimehr EMAIL logo , Mohammad Azadbakht , Jafar Akbari , Reza Enayati-fard and Sohail Azizi


Background: The aim of this study was to evaluate the efficacy of ethanol extract of Terminalia chebula in the treatment of hot water-induced burn wounds and to compare the results with silver sulfadiazine (SSD) in rats.

Methods: Five groups of ten rats were burned with hot water. Animals were administrated with topical cream at control, normal saline, 5 %, 10 % T. chebula extracts and standard SSD creams. Several parameters were assessed, including wound area, visual inspection of wound, bacteriology assessment, percentage of wound contraction and histopathological examination.

Results: The average area of wound on 10th day was 11.2 ± 3.3, 11 ± 3.2, 8.5 ± 2.3, 9.5 ± 4.2 and 5.1 ± 2.2 cm2 for SSD1 %, base cream, normal saline, herbal extract 5 % and 10 %, respectively. T. chebula 10 % cream exhibited lower wound size than SSD1 % and control groups at 10th day post burn injury. On day 15, the percentage of wound contraction in T. chebula was 5 % and 10 % more than 18 % and 53 % in comparison to SSD1 % group, respectively. Histopathological results exhibited well-formed horizontally oriented collagen fibers for appropriate tension. Strength of scar on burned tissue was better in T. chebula 5 % and 10 % as compared with control and SSD groups.

Conclusions: The results of this study showed that T. chebula extract was capable of accelerating wound healing in rats by wound contraction, and had beneficial effects more than SSD 1 % cream in the management of burn injury.


This study was supported by a grant from Mazandaran University of Medical Sciences, Sari, Iran. This research was the subject of a PhD thesis of Ebrahim Nasiri, a student of Mazandaran University of Medical Sciences.

Author contributions

All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.Research funding: None declared.Employment or leadership: None declared.Honorarium: None declared.Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


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Received: 2014-11-13
Accepted: 2015-1-15
Published Online: 2015-4-7
Published in Print: 2015-6-1

©2015 by De Gruyter

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