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Effect of 6 months intense Yoga practice on lipid profile, thyroxine medication and serum TSH level in women suffering from hypothyroidism: A pilot study

Savitri Nilakanthan, Kashinath Metri, Nagaratna Raghuram and Nagendra Hongasandra

Abstract

Background: A significant number of women in India are suffering from hypothyroidism. Hypothyroidism is characterized by elevated lipid profiles and thyroid stimulation hormone (TSH). It leads many comorbid conditions such as coronary artery disease, obesity, depression, osteoporosis, sleep apnea, and etc. Yoga is proven to be effective in reducing weight, dyslipidemia, depression and it brings the balance in autonomous nervous system. We aimed to study the effect of 6 months yoga practice on lipid profile, thyroxine requirement and serum TSH in women suffering from hypothyroidism.

Methods: Twenty-two household women suffering from hypothyroidism between the age range of 30 and 40 (mean±SD; 36.7±3.2) years, with average 4±1.12-year history of hypothyroidism were included in this study. Subjects with known cardiac issues, hypertension, history, recent surgery, slip disc and low back pain were excluded from this study. None of the subjects were on any other medication except thyroxine which was kept during the intervention phage (mean 65.78±22.74 mcg). All the subjects underwent 6 months of yoga practice 1 h daily for 4 days a week. Lipid profile, thyroxine dosage and serum TSH level were assessed before and after intervention. Data was analyzed using paired sample t test & Wilcoxon’s signed rank test.

Results: The paired sample t-test showed significant reduction in total cholesterol (p=0.006; –8.99 %), low-density lipoprotein (LDL) (p=0.002; –9.81 %) and triglycerides (p=0.013; –7.6 %), and there was a significant improvement in high-density lipoprotein (HDL) (p=0.02; +9.65 %) along with nonsignificant reduction in TSH level (p=0.452; –9.72 %). Wilcoxon signed-rank test showed significant reduction in thyroxine medication score (p=0.029; –15.30 %) from.

Conclusion: 6 months practice of yoga may help in improving cholesterol level, serum TSH, may also help in reducing the thyroxine requirement in female patients suffering from hypothyroidism. However, further randomized controlled studies need to be conducted to confirm the present finding.

Acknowledgments

The authors are thankful to all the subjects who have participated in this study without whose cooperation this study would not have been completed. We are grateful to all the endocrinologist who have helped in monitoring the thyroxine medication in the study.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. Vedavathi KJ, Shekharappa KR, Venkatesh G. Reaction time study as a tool to identify central nervous system affect due to hypothyroidism. Int J Health Sci Res 2013;3:29–32. Search in Google Scholar

2. Unnikrishnan AG, Kalra S, Sahay RK. Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Indian J Endocrinol Metab 2013 Jul–Aug; 17:647. Search in Google Scholar

3. Singh P, Singh B, Dave R, Udainiya R. The impact of yoga upon female patients suffering from hypothyroidism. Complement Ther Clin Pract 2011;17:132–4. Search in Google Scholar

4. Michalopoulou G, Alevizaki M, Piperingos G, Mitsibounas D, Mantzos E, Adamopoulos P, et al. High serum cholesterol levels in persons with ‘high-normal’ TSH levels: should one extend the definition of subclinical hypothyroidism? Eur J Endocrinol 1998;138:141–5. Search in Google Scholar

5. Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab 2003;88:2438–44. Search in Google Scholar

6. Ribot C, Tremollieres F, Pouilles JM, Louvet JP. Bone mineral density and thyroid hormone therapy. Clin Endocrinol 1990;33:143–54. Search in Google Scholar

7. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Int Med 2000;160:526–34. Search in Google Scholar

8. Guarracino JL, Savino S, Edelstein S. Yoga participation is beneficial to obesity prevention, hypertension control, and positive quality of life. Top Clin Nutr 2006;21:108–13. Search in Google Scholar

9. Kozasa EH, Santos RF, Rueda AD, Benedito-Silva AA, Ornellas FL, Leite JR. Evaluation of Siddha Samadhi yoga for anxiety and depression symptoms: a preliminary study 1, 2. Psychol Rep 2008;103:271–4. Search in Google Scholar

10. Swami G, Singh S, Singh KP, Gupta M. Effect of yoga on pulmonary function tests of hypothyroid patients. Indian J Physiol Pharmacol 2010 Jan–Mar;54:51–6. Search in Google Scholar

11. Telles S, Naveen, VK, Balkrishna, A, Kumar S. Short term health impact of a yoga and diet change program on obesity. Medical Science Monitor 2009;16:CR35–CR40. Search in Google Scholar

12. Nagaratna R, Nagendra HR. Yoga for obesity. Bangalore, India: Swami Vivekananda Yoga Prakashan, 2013. Search in Google Scholar

13. Mody BS. Acute effects of Surya Namaskar on the cardiovascular & metabolic system. J Bodyw Mov Ther 2011;15:343–7. Search in Google Scholar

14. Patra BS, Telles S. Positive impact of cyclic meditation on subsequent sleep. Med Sci Monit 2009;15:381. Search in Google Scholar

15. Dhansoia V, Bhargav H, Metri K. Immediate effect of mind sound resonance technique on state anxiety and cognitive functions in patients suffering from generalized anxiety disorder: A self-controlled pilot study. Int J Yoga 2014;6:1–8. Search in Google Scholar

16. Sukanta S. Effects of yogic practice on lipid profile in elderly women with type 2 diabetes mellitus. Indian J Res 2015;4:1. Search in Google Scholar

17. Rani M, Singh U, Agrawal G, Natu S, Kala S, Ghildiya A. Impact of Yoga Nidra on menstrual abnormalities in female of reproductive age. J Altern Complement Med 2013;19:925–9. Search in Google Scholar

18. Malhotra V, Singh S, Singh KP, Sharma SB, Madhu SV, Gupta P, et al. Effects of yoga asanas and pranayama in non-insulin dependent diabetes mellitus. Indian J Tradit Know 2004;3:162–7. Search in Google Scholar

19. Yoshihara K, Hiramoto T, Sudo N, Kubo C. Profile of mood states and stress-related biochemical indices in long-term yoga practitioners. Biopsychosoc Med 2011;5:1–8. Search in Google Scholar

Received: 2014-12-31
Accepted: 2016-2-23
Published Online: 2016-4-7
Published in Print: 2016-6-1

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