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Licensed Unlicensed Requires Authentication Published by De Gruyter December 5, 2017

Emblica officinalis – Anti-obesity activity

Iram Nazish and Shahid H Ansari

Abstract

Context

Emblica officinalis Gaertn. (family-Phyllanthaceae) fruits, known commonly as amla, is extensively used in Indian traditional system of medicine for the treatment of various disorders. The ethanolic E. officinalis extract is reported to have various activity such as antidiabetic, antihyperlipidemic and antioxidant activity in experimental animals.

Objective

To evaluate anti-obesity effect of aqueous E. officinalis extract in murine model of high fat diet (HFD)-induced obesity.

Materials and methods

Male Wistar rats fed with HFD (20 g/day/rat, p.o) for a period of 42 days were used to induce obesity. Aqueous E. officinalis extract (20 mg/kg bw) administered orally to HFD-fed rats from day 8 to 50 days for a period of 42 days. Body weight gain, serum lipids, insulin and leptin parameters were measured.

Results

Oral feeding of the aqueous E. officinalis extract (20 mg/kg) to HFD-induced obese rats for a period of 42 days resulted in significant reduction in body weight gain, insulin, leptin, lipids as compared to rats fed HFD alone. Further, the extract also showed significant increase in high density lipoprotein (HDL-C) levels.

Discussion and conclusions

These results show that aqueous E. officinalis extract possess significant anti-obesity potential.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-5-31
Accepted: 2017-10-9
Published Online: 2017-12-5

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