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Licensed Unlicensed Requires Authentication Published by De Gruyter May 25, 2018

Premature ovarian failure of autoimmune etiology in 46XX patients: is there a hope?

  • Ayman Shehata Dawood EMAIL logo , Mohamed Ahmed El-Sharawy , Doaa Waseem Nada and Mohamed Fadel El-Sheikh


Objectives: To evaluate the efficacy of live bee stings at fertility points and acupuncture in treating symptoms and managing infertility in premature ovarian failure (POF) of autoimmune etiology.

Patients and methods: Patients with primary POF were allocated randomly into two groups: group I: subjected to acupuncture at specific fertility points and group II: subjected to live bee stings at sites of fertility points.

Results: A total of 24 cases show significant reduction of Follicle stimulating hormone (FSH) level to normal range with gradual decline over the study duration: 13 cases in group I and 11 cases in group II. Eight cases got pregnant while the other 13 cases regained normal menses but still infertile.

Conclusions: Both bee sting therapy and acupuncture were effective in reduction of FSH levels with restoration of regular menstrual patterns and restoration of fertility. The bee sting therapy was superior in the pregnancy rate, while acupuncture was superior in alleviation of symptoms.

  1. Research funding: None declared.

  2. Employment or leadership: None declared.

  3. Honorarium: None declared.

  4. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


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Received: 2017-05-21
Accepted: 2018-03-21
Published Online: 2018-05-25

© 2018 Walter de Gruyter GmbH, Berlin/Boston

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