Background and aim
Gestational diabetes mellitus (GDM) poses a threat to the mother and child. The aim of this study was to examine the effect of acupressure on the glycemic control and insulin requirement of GDM females.
Materials and methods
Thirty GDM female patients were randomized to either the study group (SG; n=15), which was treated with acupressure and the standard antenatal care, or the control group (CG; n=15), which was treated with the standard antenatal care. Fasting and 2-h post-prandial blood glucose levels, requirement for insulin and insulin resistance were measured at 24 and 36 weeks’ gestation (WG). Also, neonatal outcomes were registered at delivery.
The pre intervention showed no statistically significant differences between SG and CG for baseline characteristics of participants (p>0.05). Within group analyses, after 12 weeks intervention had shown that 75 g oral glucose tolerance test (OGTT), insulin resistance, number of required insulin and measure of utilized insulin were significantly reduced (p<0.05), with significant increase in body mass index (BMI) (p<0.05) in both groups. All outcome measures were not significantly changed (p>0.05) between both groups at 24 and 36 WG. No significant differences (p>0.05) in pregnancy and neonatal outcomes between both groups at labor.
Acupressure may help to reduce gestational diabetes or insulin treatment for overweight female patients with GDM.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
 Scholl TO, Sowers M, Chen X, Lenders C. Maternal glucose concentration influences fetal growth, gestation, and pregnancy complications. Am J Epidemiol. 2001;154:514–20.10.1093/aje/154.6.514Search in Google Scholar
 Jimenez-Moleon JJ, Bueno-Cavanillas A, Luna-del-Castillo Jde D, Garcia-Martin M, Lardelli-Claret P, Galvez-Vargas R. Impact of different levels of carbohydrate intolerance on neonatal outcomes classically associated with gestational diabetes mellitus. Eur J Obstet Gynecol Reprod Biol. 2002;102:36–41.10.1016/S0301-2115(01)00575-9Search in Google Scholar
 Liu J, Wang SZ, Wang QL, Du JG, Wang BB. Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placental exosomes in the maternal circulation across gestation. Eur Rev Med Pharmacol Sci. 2018;22:2036–43.Search in Google Scholar
 Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373:1773–9.10.1016/S0140-6736(09)60731-5Search in Google Scholar
 Landon MB, Spong CY, Thom E, Carpenter MW, Ramin SM, Casey B, et al. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med. 2009;361:1339–48.10.1056/NEJMoa0902430Search in Google Scholar
 Bastani F. Effect of acupressure on maternal anxiety in women with gestational diabetes mellitus: a randomized clinical trial. Clin Nurs Res. 2016;25:325–41.10.1177/1054773815579344Search in Google Scholar
 Meyer-Hamme G, Friedemann T, Greten HJ, Plaetke R, Gerloff C, Schroeder S. ACUDIN - acupuncture and laser acupuncture for treatment of diabetic peripheral neuropathy: a randomized, placebo-controlled, partially double-blinded trial. BMC Neurol. 2018;18:40.10.1186/s12883-018-1037-0Search in Google Scholar
 Beijing college of traditional medicine, Shanghai college of traditional medicine, Nanjing college of traditional medicine and The acupuncture institute of the academy of college of traditional medicine, editors. Essentials of Chinese acupuncture. Beijing: Foreign languages press, 1980.Search in Google Scholar
 Gabrielle NB, Mitchell BF, Edmond AR, Nanette BO. Resistance exercise decreases the need for insulin in overweight women with gestational diabetes mellitus. Am J Obstet Gynecol. 2004;190:188–93.10.1016/S0002-9378(03)00951-7Search in Google Scholar
 Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.10.1007/BF00280883Search in Google Scholar
 Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539–53.10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-SSearch in Google Scholar
 National Council on Nutrition and Physical Activity in Norway. Extract from the Norwegian national report on physical activity and health. Scand J Med Sci Sports. 2001;11:255–7.Search in Google Scholar
 Jovanovic-Peterson L, Durak EP, Peterson CM. Randomized trial of diet versus diet plus cardiovascular conditioning on glucose levels in gestational diabetes. Am J Obstet Gynecol. 1989;161:415–9.10.1016/0002-9378(89)90534-6Search in Google Scholar
 Avery MD, Walker AJ. Acute effect of exercise on blood glucose and insulin levels in women with gestational diabetes. J Matern Fetal Med. 2001;10:52–8.10.1080/jmf.10.1.52.58-4Search in Google Scholar
 Helmrich SP, Ragland DR, Paffenbarger RS. Prevention of noninsulin- dependent diabetes mellitus with physical activity. Med Sci Sports Exerc. 1994;26:824–30.10.1249/00005768-199407000-00003Search in Google Scholar
 Kuhl C. Etiology and pathogenesis of gestational diabetes. Diabetes Care. 1998;21:B19–26.Search in Google Scholar
 Langer O, Levy J, Brustman L, Anyaegbunam A, Merkatz R, Divon M. Glycemic control in gestational diabetes mellitus: how tight is tight enough? Small for gestational age versus large for gestational age. Am J Obstet Gynecol. 1989;161:646–53.10.1016/0002-9378(89)90371-2Search in Google Scholar
 El-Mekawy HS, El Deeb AM, Ghareib HO. Effect of laser acupuncture combined with a diet-exercise intervention on metabolic syndrome in post-menopausal women. J Advanced Res. 2015;6:757–63.10.1016/j.jare.2014.08.002Search in Google Scholar
 Field T, Diego M, Hernandez-Reif M, Figueiredo B, Deeds O, Ascencio A, et al. Comorbid depression and anxiety effects on pregnancy and neonatal outcome. Infant Behav Dev. 2010;33:23–9.10.1016/j.infbeh.2009.10.004Search in Google Scholar
 Hui H. A review of treatment of diabetes by acupuncture during the past forty years. J Tradit Chin Med. 1995;15:145–54.Search in Google Scholar
 Farideh B. Effect of acupressure on maternal anxiety in women with gestational diabetes mellitus: a randomized clinical trial. Clin Nurs Res. 2016;25:325–41.10.1177/1054773815579344Search in Google Scholar PubMed
 Stafne N, Kjell A, Pal R, Torbjørn M, Sven M, Mørkved S. Regular exercise during pregnancy to prevent gestational diabetes a randomized controlled trial. Obstetrics Gynecol. 2012;119:29–36.10.1097/AOG.0b013e3182393f86Search in Google Scholar PubMed
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