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Licensed Unlicensed Requires Authentication Published by De Gruyter May 19, 2020

The effects of omega-3 on the sleep quality of patients with uremic pruritus undergoing hemodialysis: a randomized crossover study

  • Mansoureh Heydarbaki , Monireh Amerian , Ali Abbasi , Farzaneh Amanpour , Reza Mohammadpourhodki and Hossein Ebrahimi EMAIL logo

Abstract

Objectives

Information on sleep quality and its effective factors in the patients undergoing hemodialysis are important factors in future planning for improving sleep quality and ultimately the quality of life in these patients. The present study investigated the effect of omega-3 on the sleep quality of hemodialysis patients.

Methods

The 52 hemodialysis patients were randomized into two groups and underwent two different treatment modes (A and B). The first group was given omega-3 and cetirizine and the second group only received cetirizine for six weeks. After one week wash out, the study was followed by crossover treatment in both groups for six weeks. Sleep quality and pruritus severity were evaluated in patients before the intervention and at the end of each treatment period using the Pittsburgh Sleep Quality Index and the Yosipovitch Itch Questionnaire. The collected data was analyzed using repeated measures ANOVA and the Pearson correlation coefficient.

Results

The results of the study showed that majority of the patients (94.2%) had poor sleep quality (sleep score > 5 based on the questionnaire) and 5.8% of the patients had favorable sleep quality (sleep score < 5). Repeated measures ANOVA showed that sleep quality scores were different in two groups in phases 0, I and II (p <0.001).

Conclusions

Sleep quality improved in both modes but more improvement was observed in mode A. Therefore, omega-3 fatty acids can be used as a suitable method for improving sleep quality in hemodialysis patients.


Corresponding author: Hossein Ebrahimi, PhD, Randomized Controlled Trial Research Center, Shahroud University of Medical Sciences, 7th Sq., Shahroud, Islamic Republic of Iran, Phone: 0098 233 2393811, Fax: 0098 233 2394852, E-mail:

Acknowledgements

This article is derived from a master thesis in nursing care in Shahroud University of Medical Sciences. We appreciate the helps of the deputy of research department in this university, the staff and patients of the Hemodialysis Center in Shahroud Imam Hossein Hospital.

  1. Research funding: None declared.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Employment or leadership: None declared.

  5. Honorarium: None declared.

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Received: 2019-02-19
Accepted: 2020-02-16
Published Online: 2020-05-19

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