Accessible Unlicensed Requires Authentication Published by De Gruyter September 17, 2019

Non-pharmacological management of gestational diabetes: The role of myo-inositol

Federica Di Guardo ORCID logo, Jessica Marika Currò, Gaetano Valenti, Paola Rossetti, Luisa Maria Di Gregorio, Francesca Conway, Benito Chiofalo, Simone Garzon ORCID logo, Simone Bruni and Gianluca Rizzo


Gestational diabetes mellitus (GDM) is the most common metabolic disorder occurring in pregnancy.

GDM plays an important role in the current diabetes epidemic: exposure to a high glycemic environment during the early stages of development increases the risk of the fetus to develop type two diabetes mellitus (T2DM) in adult life.

Various cardiometabolic risk factors are linked to GDM. A thorough knowledge of the risk factors and genes involved in the development of GDM, along with an understanding of the underlying pathophysiological mechanisms are crucial to properly identify patients at risk of developing this condition. There is growing evidence showing that myo-inositol, combined with an appropriate therapeutic regimen for GDM, can provide additional benefits to the patient. The aim of this review is to analyze the role of inositol isomers – especially myo-inositol (MYO-INS) – in the treatment of patients with GDM.



  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: None declared.


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Received: 2019-05-19
Accepted: 2019-07-03
Published Online: 2019-09-17

© 2019 Walter de Gruyter GmbH, Berlin/Boston