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Licensed Unlicensed Requires Authentication Published by De Gruyter June 18, 2020

Endocannabinoids release after Osteopathic Manipulative Treatment. A brief review

  • Andrea Buscemi , Simona Martino , Santi Scirè Campisi , Alessandro Rapisarda and Marinella Coco EMAIL logo



Since 70’s, scientific research has analyzed how many acute and chronic issues can affect body systems. In case of depression, chronic pain and overtraining, centrals and peripherals systems act to manage and maintain body adaptations. The aim of this study is to evaluate if the osteopathic treatment can increase the release of Cannabinoid receptor (CB) and promote the linkage with their receptors.


Documents research is based on PubMed and Google Scholar databases. Keywords used were “osteopathic treatment”, “manual therapy”, “endocannabinoid”, “beta endorphin (BE)”, and “ CB1” “massage”. From 70 articles collected (published in the last 10 years) 52 were excluded as non-relevant to the study aim.


The Key points have been the similar results found by different authors during different treatment periods and with different doses. From 22 articles examined, 13 have established positive effects on CB increasing post osteopathic treatment, three articles have indicated the most targeted tissues in which the substances are most expressed, two articles indicate how physical activities produce antalgic effects by increasing CB’s values.


As a result of this review, osteopathic manipulation treatment seems to be a valid and effective instrument for the treatment of a series of pathologies such as chronic low back pain, fibromyalgia, spinal cord lesions, myofascial graft point, migraine, GI tract dysfunctions, and depression.

Corresponding author: Marinella Coco, Department of Biomedical and Biotechnological Sciences, University of Catania and Research Center on Motor Activities (CRAM), University of Catania Torre Biologica, Via Santa Sofia, 89, 95123, Catania, Italy, E-mail:


The authors thank the CSDOI (Centro StudiOsteopatiaItaliano) of Catania for providing technical and scientific support for the study, and Dr. Andrea Buscemi for following the research step by step.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical statement: Primary data for human nor for animals were not collected for this research work.


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Received: 2019-09-20
Accepted: 2020-01-30
Published Online: 2020-06-18

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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