Abstract
Background
In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown.
Objectives
Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM.
Methods
In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention.
Results
The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05).
Conclusions
This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.
Acknowledgments
Vice-Chancellor for Research Affairs of Ahvaz Jundishapur University of Medical Sciences financially supported this study (NRC-9505).
Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interest: Authors state no conflict of interest.
Informed consent: The informed consent was obtained from all participants.
Ethical approval: The Ethics Committee of the Ahvaz Jundishapur University of Medical Science approved this study (No. IR.AJUMS.REC.1395.548).
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