Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter February 3, 2021

Herbal foodstuffs in Avicenna’s recommended diet to improve sperm quality and increase male fertility; an evidence-based approach

  • Azita Sadogh , Narjes Gorji and Reihaneh Moeini EMAIL logo

Abstract

Attention to diet was considered important issues in improvement of men infertility in Persian Medicine (PM). The purpose of this study was to extract herbal foodstuffs introduced by Avicenna, one of the greatest PM physicians to improve the semen production and to provide evidence of their impact on the basis of current studies.“Canon of Medicine”, the most important Avecinna's book, was searched with keywords equivalent to semen, fertility and infertility, main herbal foodstuffs were extracted and was searched with keywords sperm, semen, infertility, and fertility in Google scholar, PubMed and Scopus databases. Manuscripts from 1950 up to December 2019 were selected and reviewed. Almond, Onion, Chickpea, Garlic, Coconut, Palm date, Sesame, Fenugreek, Carrot, Fig, Grapes, Pistachio, Hazelnut and Walnut are among main foodstuffs which recommended by Avicenna and there is also evidence that they have positive effects on testosterone production and improvement of various sperm parameters, including count, motility and morphology. Containing large amount of different macro and micronutrients such as vitamins including vit B, C, A and E, minerals such as Mg, Se, Zn, Cu and Fe, important unsaturated fatty acids such as linoleic and oleic acids, amino acids such as lysine and arginine and phytochemicals such as polyphenols, flavonoids, triterpenes and steroids can be considered as a main factor in the effectiveness of these foodstuffs. Designing a diet based on the fruits, vegetables, nuts and seeds that Avicenna has recommended, may be effective in treating male infertility but further studies are needed to clarify this issue. Research on the effectiveness of his other recommended foodsuffs may also offer new treatments and supplements for this purpose.


Corresponding author: Reihaneh Moeini, MD, PhD, Assistant Professor, Department of Traditional Medicine, School of Iranian Traditional Medicine, Traditional Medicine and History of Medical Sciences Research Center, Babol University of Medical Science, Babol, Islamic Republic of Iran, Phone: +98 (11) 32194728 30, Fax: +98 (11) 32194728 30, E-mail:

  1. Research funding: There is no funding.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

References

1. Vander Borght, M, Wyns, C. Fertility and infertility: definition and epidemiology. Clin Biochem 2018;62:2–10. https://doi.org/10.1016/j.clinbiochem.2018.03.012.Search in Google Scholar

2. Agarwal, A, Mulgund, A, Hamada, A, Chyatte, MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol 2015;13:37. https://doi.org/10.1186/s12958-015-0032-1.Search in Google Scholar

3. Kumar, N, Singh, AK. Trends of male factor infertility, an important cause of infertility: a review of literature. J Hum Reprod Sci 2015;8:191–6. https://doi.org/10.4103/0974-1208.170370.Search in Google Scholar

4. Tang, Q, Wu, W, Zhang, J, Fan, R, Liu, M. Environmental factors and male infertility. Spermatozoa – facts and perspectives. IntechOpen; 2017.10.5772/intechopen.71553Search in Google Scholar

5. Salas-Huetos, A, Bullo, M, Salas-Salvado, J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update 2017;23:371–89. https://doi.org/10.1093/humupd/dmx006.Search in Google Scholar

6. Nassan, FL, Chavarro, JE, Tanrikut, C. Diet and men’s fertility: does diet affect sperm quality? Fertil Steril 2018;110:570–7. https://doi.org/10.1016/j.fertnstert.2018.05.025.Search in Google Scholar

7. Guttmacher, AF. Early attitudes toward infertility. Fertil Steril 1953;4:250–62. https://doi.org/10.1016/s0015-0282(16)31322-x.Search in Google Scholar

8. Ibn Sina, H. Kitab al Qanoun fi Al Toubb (The book of the canon of medicine). Beirut: American University of Beirut; 2007.Search in Google Scholar

9. Bisen, S, Emerald, M. Nutritional and therapeutic potential of garlic and onion (Allium sp.). Curr Nutr Food Sci 2016;12:190–9.10.2174/1573401312666160608121954Search in Google Scholar

10. Roldán-Marín, E, Sánchez-Moreno, C, Lloría, R, de Ancos, B, Cano, MP. Onion high-pressure processing: flavonol content and antioxidant activity. LWT – Food Sci Technol 2009;42:835–41. https://doi.org/10.1016/j.lwt.2008.11.013.Search in Google Scholar

11. Zhang, S-l, Peng, D, Xu, Y-c, Lü, S-w, Wang, J-j. Quantification and analysis of anthocyanin and flavonoids compositions, and antioxidant activities in onions with three different colors. J Integr Agric 2016;15:2175–81. https://doi.org/10.1016/s2095-3119(16)61385-0.Search in Google Scholar

12. Shokoohi, M, Madarek, EOS, Khaki, A, Shoorei, H, Khaki, AA, Soltani, M, et al.. Investigating the effects of onion juice on male fertility factors and pregnancy rate after testicular torsion/detorsion by intrauterine insemination method. Int J Womens Health Reprod Sci 2018;6:499–505. https://doi.org/10.15296/ijwhr.2018.82.Search in Google Scholar

13. Ola-Mudathir, KF, Suru, SM, Fafunso, MA, Obioha, UE, Faremi, TY. Protective roles of onion and garlic extracts on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats. Food Chem Toxicol 2008;46:3604–11. https://doi.org/10.1016/j.fct.2008.09.004.Search in Google Scholar

14. Ige, SF, Akhigbe, RE. The role of Allium cepa on aluminum-induced reproductive dysfunction in experimental male rat models. J Hum Reprod Sci 2012;5:200. https://doi.org/10.4103/0974-1208.101022.Search in Google Scholar

15. Izawa, H, Kohara, M, Aizawa, K, Suganuma, H, Inakuma, T, Watanabe, G, et al.. Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles. Biosci Biotechnol Biochem 2008;72:1235–41. https://doi.org/10.1271/bbb.70705.Search in Google Scholar

16. Khaki, A, Farzadi, L, Ahmadi, S, Ghadamkheir, E, afshin Khaki, A, Sahizadeh, R. Recovery of spermatogenesis by Allium cepa in Toxoplasma gondii infected rats. Afr J Pharm Pharmacol 2011;5:903–7. https://doi.org/10.5897/ajpp11.277.Search in Google Scholar

17. Chae, MR, Kang, SJ, Lee, KP, Choi, BR, Kim, HK, Park, JK, et al.. Onion (Allium cepa L.) peel extract (OPE) regulates human sperm motility via protein kinase C-mediated activation of the human voltage-gated proton channel. Andrology 2017;5:979–89. https://doi.org/10.1111/andr.12406.Search in Google Scholar

18. Valente, C, Aboua, G, Duplessis, SS. Garlic and its effects on health with special reference to the reproductive system. ABOUA G antioxidant-antidiabetic agents and human health 3a edição Africa do Sul. IntechOpen; 2014:259–577 p.10.5772/57191Search in Google Scholar

19. Oi, Y, Imafuku, M, Shishido, C, Kominato, Y, Nishimura, S, Iwai, K. Garlic supplementation increases testicular testosterone and decreases plasma corticosterone in rats fed a high protein diet. J Nutr 2001;131:2150–6. https://doi.org/10.1093/jn/131.8.2150.Search in Google Scholar

20. Okoro, VMO, Mbajiorgu, CA, Mbajiorgu, EF. Semen quality characteristics of Koekoek breeder cocks influenced by supplemental inclusion levels of onion and garlic mixture at 35-41 weeks of age. Rev Bras Zootec 2016;45:433–40. https://doi.org/10.1590/s1806-92902016000800002.Search in Google Scholar

21. Al-Bekairi, AM, Shah, AH, Qureshi, S. Effect of Allium sativum on epididymal spermatozoa, estradiol-treated mice and general toxicity. J Ethnopharmacol 1990;29:117–25. https://doi.org/10.1016/0378-8741(90)90049-y.Search in Google Scholar

22. Abdelmalik, SW. Histological and ultrastructural changes in the adult male albino rat testes following chronic crude garlic consumption. Ann Anat 2011;193:134–41. https://doi.org/10.1016/j.aanat.2010.12.003.Search in Google Scholar PubMed

23. Hammami, I, Nahdi, A, Atig, F, Kouidhi, W, Amri, M, Mokni, M, et al.. Effects of garlic fractions consumption on male reproductive functions. J Med Food 2013;16:82–7. https://doi.org/10.1089/jmf.2011.0335.Search in Google Scholar PubMed

24. Hammami, I, Amara, S, Benahmed, M, El May, MV, Mauduit, C. Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action. Reprod Biol Endocrinol 2009;7:65. https://doi.org/10.1186/1477-7827-7-65.Search in Google Scholar PubMed PubMed Central

25. Hammami, I, Nahdi, A, Mauduit, C, Benahmed, M, Amri, M, Ben Amar, A, et al.. The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding. Asian J Androl 2008;10:593–601. https://doi.org/10.1111/j.1745-7262.2008.00358.x.Search in Google Scholar PubMed

26. Ghalehkandi, JG. Garlic (Allium sativum) juice protects from semen oxidative stress in male rats exposed to chromium chloride. Anim Reprod 2018;11:526–32.Search in Google Scholar

27. Nasr, AY. The impact of aged garlic extract on adriamycin-induced testicular changes in adult male Wistar rats. Acta Histochem 2017;119:648–62. https://doi.org/10.1016/j.acthis.2017.07.006.Search in Google Scholar PubMed

28. El-Akabawy, G, El-Sherif, NM. Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis. Acta Histochem 2016;118:456–63. https://doi.org/10.1016/j.acthis.2016.04.008.Search in Google Scholar PubMed

29. Lee, SC, Hwang, SY, Kim, SW, Kim, SK. Ethanol extract of Allium sativum attenuates testicular and liver toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. J Med Food 2009;12:93–9. https://doi.org/10.1089/jmf.2007.0620.Search in Google Scholar PubMed

30. Asadpour, R, Azari, M, Hejazi, M, Tayefi, H, Zaboli, N. Protective effects of garlic aquous extract (Allium sativum), vitamin E, and N-acetylcysteine on reproductive quality of male rats exposed to lead. Vet Res Forum 2013;4:251–7.Search in Google Scholar

31. Ouarda, M, Abdennour, C. Evaluation of the therapeutic efficiency of raw garlic on reproduction of domestic rabbits under lead induced toxicity. Ann Biol Res 2011;2:38993.Search in Google Scholar

32. Parween, S, Nawaz, K, Roy, R, Pole, AK, Venkata Suresh, B, Misra, G, et al.. An advanced draft genome assembly of a desi type chickpea (Cicer arietinum L.). Sci Rep 2015;5:12806. https://doi.org/10.1038/srep12806.Search in Google Scholar PubMed PubMed Central

33. Jukanti, AK, Gaur, PM, Gowda, CL, Chibbar, RN. Nutritional quality and health benefits of chickpea (Cicer arietinum L.): a review. Br J Nutr 2012;108(Suppl 1):S11–26. https://doi.org/10.1017/s0007114512000797.Search in Google Scholar

34. Iqbal, A, Ateeq, N, Khalil, IA, Perveen, S, Saleemullah, S. Physicochemical characteristics and amino acid profile of chickpea cultivars grown in Pakistan. J Foodserv 2006;17:94–101. https://doi.org/10.1111/j.1745-4506.2006.00024.x.Search in Google Scholar

35. Sayed, AA, Ali, AA, Mohamed, HRH. Fertility enhancing efficacy of Cicer arietinum in male albino mice. Cell Mol Biol (Noisy-le-grand) 2018;64:29–38. https://doi.org/10.14715/cmb/2018.64.4.6.Search in Google Scholar

36. Sajja, R, Venkatesh, V, Suneetha, B, Srinivas, N. Evaluation of aphrodisiac activity of methanolic extract of Cicer arietinum seeds in sexually sluggish male albino rats. Int J Pharm 2014;4:309–13.Search in Google Scholar

37. Darwish, A, Elsaid, TA, Mohamed, FF. Protective effect of Cicer arietinum on infertility of male rats induced by gibrillic acid. Egypt J Chem Environ Health 2015:1;153–62.10.21608/ejceh.2015.232336Search in Google Scholar

38. Xiao, Y, Xu, P, Fan, H, Baudouin, L, Xia, W, Bocs, S, et al.. The genome draft of coconut (Cocos nucifera). GigaScience 2017;6:gix095. https://doi.org/10.1093/gigascience/gix095.Search in Google Scholar PubMed PubMed Central

39. Lima, EB, Sousa, CN, Meneses, LN, Ximenes, NC, Santos Junior, MA, Vasconcelos, GS, et al.. Cocos nucifera (L.) (Arecaceae): a phytochemical and pharmacological review. Braz J Med Biol Res 2015;48:953–64. https://doi.org/10.1590/1414-431x20154773.Search in Google Scholar PubMed PubMed Central

40. Kunle-Alabi, OT, Akindele, OO, Odoh, MI, Oghenetega, BO, Raji, Y. Comparative effects of coconut water and N-acetyl cysteine on the hypothalamo-pituitary-gonadal axis of male rats. Songklanakarin J Sci Technol 2017;39:759–64.Search in Google Scholar

41. Nair, SVG, Rajamohan, T. The role of coconut water on nicotine-induced reproductive dysfunction in experimental male rat model. Food Nutr Sci 2014;2014.10.4236/fns.2014.512122Search in Google Scholar

42. Kunle-Alabi, OT, Akindele, OO, Oyovwi, MO, Duro-Ladipo, MA, Raji, Y. Cocos nucifera L. water improves reproductive indices in Wistar Rats. Afr J Med Med Sci 2014;43:305–13.Search in Google Scholar

43. Kunle-Alabi, O, Akindele, O, Oyovwi, M, Duro-Ladipo, M, Raji, Y. Effects of coconut water on reproductive functions in danazol treated wistar rats. FASEB J 2015;29(1 Suppl):685–1.10.1096/fasebj.29.1_supplement.685.1Search in Google Scholar

44. Ogedengbe, O, Naidu, E, Akang, E, Offor, U, Onanuga, I, Peter, A, et al.. Virgin coconut oil extract mitigates testicular‐induced toxicity of alcohol use in antiretroviral therapy. Andrology 2018;6:616–26. https://doi.org/10.1111/andr.12490.Search in Google Scholar PubMed

45. Abarikwu, S, Benjamin, S, Ebah, S, Obilor, G, Agbam, G. Oral administration of Moringa oleifera oil but not coconut oil prevents mercury‐induced testicular toxicity in rats. Andrologia 2017;49:e12597. https://doi.org/10.1111/and.12597.Search in Google Scholar PubMed

46. Oliveira, KG, Miranda, SA, Leao, DL, Brito, AB, Santos, RR, Domingues, SF. Semen coagulum liquefaction, sperm activation and cryopreservation of capuchin monkey (Cebus apella) semen in coconut water solution (CWS) and TES-TRIS. Anim Reprod Sci 2011;123:75–80. https://doi.org/10.1016/j.anireprosci.2010.11.002.Search in Google Scholar PubMed

47. Silva, MA, Peixoto, GC, Santos, EA, Castelo, TS, Oliveira, MF, Silva, AR. Recovery and cryopreservation of epididymal sperm from agouti (Dasyprocta aguti) using powdered coconut water (ACP-109c) and Tris extenders. Theriogenology 2011;76:1084–9. https://doi.org/10.1016/j.theriogenology.2011.05.014.Search in Google Scholar PubMed

48. Viveiros, AT, Nascimento, AF, Orfao, LH, Isau, ZA. Motility and fertility of the subtropical freshwater fish streaked prochilod (Prochilodus lineatus) sperm cryopreserved in powdered coconut water. Theriogenology 2010;74:551–6. https://doi.org/10.1016/j.theriogenology.2010.03.018.Search in Google Scholar PubMed

49. Uchoa, DC, Silva, TF, Mota Filho, AC, Silva, LD. Intravaginal artificial insemination in bitches using frozen/thawed semen after dilution in powdered coconut water (ACP-106c). Reprod Domest Anim 2012;47(Suppl 6):289–92. https://doi.org/10.1111/rda.12077.Search in Google Scholar PubMed

50. Bottone, A, Cerulli, A, D’Urso, G, Masullo, M, Montoro, P, Napolitano, A, et al.. Plant specialized metabolites in hazelnut (Corylus avellana) kernel and byproducts: an update on chemistry, biological activity, and analytical aspects. Planta Med 2019;85:840–55. https://doi.org/10.1055/a-0947-5725.Search in Google Scholar PubMed

51. Taş, NG, Gökmen, V. Bioactive compounds in different hazelnut varieties and their skins. J Food Compos Anal 2015;43:203–8.10.1016/j.jfca.2015.07.003Search in Google Scholar

52. Li, H, Parry, JW. Phytochemical compositions, antioxidant properties, and colon cancer antiproliferation effects of Turkish and Oregon hazelnut. Food Nutr Sci 2011;2011.10.4236/fns.2011.210153Search in Google Scholar

53. Kati, B, Oguz, F, Yilmaz, I, Akdemir, E, Altintas, R, Akpolat, N, et al.. How do vegetable oils (hazelnut and canola) affect the reproductive system in male rats? Arch Ital Urol Androl 2018;90:54–8. https://doi.org/10.4081/aiua.2018.1.54.Search in Google Scholar PubMed

54. Kara, H, Orem, A, Yulug, E, Yucesan, FB, Kerimoglu, G, Yaman, SO, et al.. Hazelnut consumption improves testicular antioxidant function and semen quality in young and old male rats. Food Chem 2019;294:1–8. https://doi.org/10.1016/j.foodchem.2019.04.087.Search in Google Scholar PubMed

55. Salas-Huetos, A, Moraleda, R, Giardina, S, Anton, E, Blanco, J, Salas-Salvado, J, et al.. Effect of nut consumption on semen quality and functionality in healthy men consuming a Western-style diet: a randomized controlled trial. Am J Clin Nutr 2018;108:953–62. https://doi.org/10.1093/ajcn/nqy181.Search in Google Scholar PubMed

56. Prasad, K, Haq, R, Bansal, V, Siddiqui, MW, Ilahy, R. Carrot secondary metabolites and their prospective health benefits. Plant Secondary Metabolites 2016;2.10.1201/9781315366319-5Search in Google Scholar

57. Arscott, SA, Tanumihardjo, SA. Carrots of many colors provide basic nutrition and bioavailable phytochemicals acting as a functional food. Compr Rev Food Sci Food Saf 2010;9:223–39. https://doi.org/10.1111/j.1541-4337.2009.00103.x.Search in Google Scholar

58. Zareba, P, Colaci, DS, Afeiche, M, Gaskins, AJ, Jorgensen, N, Mendiola, J, et al.. Semen quality in relation to antioxidant intake in a healthy male population. Fertil Steril 2013;100:1572–9. https://doi.org/10.1016/j.fertnstert.2013.08.032.Search in Google Scholar PubMed PubMed Central

59. Fakhrildin, MBM, AL-Zubaidi, UI, Hussein, ZM, Al-Saadi, RR. Role of alcoholic extract of Black Carrot in improvement of human sperm parameters during in vitro activation. Iraqi J Embryos Infertil Res 2014;4:56–60.Search in Google Scholar

60. Nouri, M, Khaki, A, Fathiazar, F, RASHIDI, MR. The protective effects of carrot seed extract on spermatogenesis and cauda epididymal sperm reserves in gentamicin treated rats. Cell 2009;11:327–33.Search in Google Scholar

61. Oh, H-G, Lee, H-Y, Seo, M-Y, Kang, Y-R, Kim, J-H, Park, J-W, et al.. Effects of Ficus carica paste on constipation induced by a high-protein feed and movement restriction in beagles. Lab Anim Res 2011;27:275–81. https://doi.org/10.5625/lar.2011.27.4.275.Search in Google Scholar PubMed PubMed Central

62. Palaniyappan, V, Bommireddy, EP, Gudipudi, H, Chitturi, RD, Yandamala, N. In vivo fertility enhancing activity (aprodisiac) of Ficus carica fruit on male wistar rats. Int J Pharm Pharm Sci 2013;5:516–8.Search in Google Scholar

63. Zaenuri, LA, Susilawati, T, Sumitro, S, Wahyuningsih, S. Effects of additional crude extract of fig fruit (Ficus carica L.) into tris egg yolk based extender on quality of buck semen. J Biol Agric Healthcare 2014;4:21–7.Search in Google Scholar

64. Zaenuri, LA, Susilawati, T, Sumitro, S, Wahyuningsih, S. Preservation effect of crude fig fruit filtrate (Ficus carica L.) added in to tris egg yolk based extender on capacitating, acrosome and fertility of half blood boer buck spermatozoa. J Agric Vet Sci 2014;7:60–8. https://doi.org/10.9790/2380-07526068.Search in Google Scholar

65. Jahanban-Esfahlan, A, Ostadrahimi, A, Tabibiazar, M, Amarowicz, R. A comparative review on the extraction, antioxidant content and antioxidant potential of different parts of walnut (Juglans regia L.) fruit and tree. Molecules 2019;24:2133. https://doi.org/10.3390/molecules24112133.Search in Google Scholar PubMed PubMed Central

66. Arcan, I, Yemenicioğlu, A. Antioxidant activity and phenolic content of fresh and dry nuts with or without the seed coat. J Food Compos Anal 2009;22:184–8. https://doi.org/10.1016/j.jfca.2008.10.016.Search in Google Scholar

67. Abedinzade, M, Mokhtari, M, Zarbakhsh, S, Nasseran, S. The effect of the alcoholic extract of walnut on the testis tissue of adult male rats. Armaghane-Danesh 2012;17:215–24.Search in Google Scholar

68. Ghorbani, R, Mokhtari, T, Khazaei, M, Salahshoor, M, Jalili, C, Bakhtiari, M. The effect of walnut on the weight, blood glucose and sex hormones of diabetic male rats. Int J Morphol 2014;32. https://doi.org/10.4067/s0717-95022014000300015.Search in Google Scholar

69. Elgazar, AF. Protective role of walnut seeds extract and vitamin E against testicular toxicity induced by cyclophosphamide in male rats. J Adv Med Med Res 2016:1–10. https://doi.org/10.9734/bjmmr/2016/29765.Search in Google Scholar

70. Robbins, WA, Xun, L, FitzGerald, LZ, Esguerra, S, Henning, SM, Carpenter, CL. Walnuts improve semen quality in men consuming a Western-style diet: randomized control dietary intervention trial. Biol Reprod 2012;87:101. https://doi.org/10.1095/biolreprod.112.101634.Search in Google Scholar PubMed

71. Robbins, W, Kim, H, Houman, J, Lee, G-W. Randomized clinical trial: effect of walnuts on semen parameters and male fertility (P18-042-19). Curr Dev Nutr 2019;3(Suppl 1):nzz039. https://doi.org/10.1093/cdn/nzz039.p18-042-19.Search in Google Scholar

72. Ghnimi, S, Umer, S, Karim, A, Kamal-Eldin, A. Date fruit (Phoenix dactylifera L.): an underutilized food seeking industrial valorization. NFS J 2017;6:1–10. https://doi.org/10.1016/j.nfs.2016.12.001.Search in Google Scholar

73. Parvin, S, Easmin, D, Sheikh, A, Biswas, M, Sharma, SCD, Jahan, MGS, et al.. Nutritional analysis of date fruits (Phoenix dactylifera L.) in perspective of Bangladesh. Am J Life Sci 2015;3:274–8. https://doi.org/10.11648/j.ajls.20150304.14.Search in Google Scholar

74. Rasekh, A, Jashni, HK, Rahmanian, K, Jahromi, AS. Effect of palm pollen on sperm parameters of infertile man. Pak J Biol Sci 2015;18:196–9. https://doi.org/10.3923/pjbs.2015.196.199.Search in Google Scholar PubMed

75. Marbeem, MI, Marbut, MM, Bahaaldean, EF, Al-sanafi, AE. The effect of date palm pollen & zinc sulphate in the treatment of human male infertility. Tikrit J Pharm Sci 2006;2:31–4.Search in Google Scholar

76. Mehraban, F, Jafari, M, Akbartabar Toori, M, Sadeghi, H, Joodi, B, Mostafazade, M, et al.. Effects of date palm pollen (Phoenix dactylifera L.) and Astragalus ovinus on sperm parameters and sex hormones in adult male rats. Iran J Reprod Med 2014;12:705–12.Search in Google Scholar

77. Hosseini, SE, Mehrabani, D, Al Sadat, RF. The effect of palm pollen extract on sexual hormones and the numbers of spermatozoa dynastic cell in adult male mice. Majallah-i pizishki-i Danishgah-i Ulum-i Pizishki va Khadamat-i Bihdashti-i. Darmani-i Tabriz 2015;37:20.Search in Google Scholar

78. Al-Samarrai, RRH, Al-Samarrai, ASM, Al-Samarrai, A-MH. Effect evaluation of Iraqi date palm pollen on sex hormones level of male local rabbits. Chem Adv Mater 2017;2.Search in Google Scholar

79. Selmani, C, Chabane, D, Bouguedoura, N. Ethnobotanical survey of Phoenix dactylifera L. pollen used for the treatment of infertility problems in Algerian oases. Afr J Tradit, Complementary Altern Med 2017;14:175–86. https://doi.org/10.21010/ajtcam.v14i3.19.Search in Google Scholar PubMed PubMed Central

80. Hassan, WA, El-kashlan, AM, Mohamed, NA. Egyptian date palm pollen ameliorates testicular dysfunction induced by cadmium chloride in adult male rats. J Am Sci 2012;8:659–69.Search in Google Scholar

81. El-Kashlan, AM, Nooh, MM, Hassan, WA, Rizk, SM. Therapeutic potential of date palm pollen for testicular dysfunction induced by thyroid disorders in male rats. PLoS One 2015;10:e0139493. https://doi.org/10.1371/journal.pone.0139493.Search in Google Scholar PubMed PubMed Central

82. Jahromi, AR, Rasooli, R, Kamali, Y, Ahmadi, N, Sattari, E. Short-term effects of date palm extract (Phoenix dactylifera) on ischemia/reperfusion injury induced by testicular torsion/detorsion in rats. Pharmacognosy Res 2017;9:69–73. https://doi.org/10.4103/0974-8490.199769.Search in Google Scholar PubMed PubMed Central

83. Khalifa, WH, El-Sisy, GA, El-Nattat, WS, Mourad, A, Maghraby, N. Effect of water extract of dates palm (Phoenix dactylifera) on semen characteristics and oxidative status in serum of male New Zealand rabbits under heat stress. Asian Pac J Reprod 2019:22–6.10.4103/2305-0500.220981Search in Google Scholar

84. Khatib, S, Vaya, J. Fig, carob, pistachio, and health. Bioactive foods in promoting health. Academic press; 2010:245–63 p.10.1016/B978-0-12-374628-3.00017-7Search in Google Scholar

85. Kashaninejad, M, Tabil, L. Pistachio (Pistacia vera L.). Postharvest biology and technology of tropical and subtropical fruits. Woodhead Publishing; 2011:218–47e p.10.1533/9780857092618.218Search in Google Scholar

86. Shariati, M, Sepehrara, L. Effect of Pistacia vera oil on pituitary gonad axis and histological testis changes in adult male rats. Armaghane Danesh 2013;18:641–9.Search in Google Scholar

87. Aldemir, M, Okulu, E, Neselioglu, S, Erel, O, Kayigil, O. Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction. Int J Impot Res 2011;23:32–8. https://doi.org/10.1038/ijir.2010.33.Search in Google Scholar PubMed

88. Li, S, Geng, F, Wang, P, Lu, J, Ma, M. Proteome analysis of the almond kernel (Prunus dulcis). J Sci Food Agric 2016;96:3351–7. https://doi.org/10.1002/jsfa.7514.Search in Google Scholar PubMed

89. Sahib, ZH. Assessment of anxiolytic activity of nuts of Prunus amygdalus Dulcis (almond) in mice. Med J Babylon 2014;11:817–24.Search in Google Scholar

90. Hussein, RH, Raheem, SA. Effects of almond seed oil extraction and some antioxidant agents on sperm quality in alloxan-induced diabetes mellitus rat. Int J Curr Microbiol Appl Sci 2015;4:93–104.Search in Google Scholar

91. Amoo, S, Okorogbona, A, Du Plooy, C, Venter, S. Sesamum indicum. In Medicinal spices and vegetables from Africa. Elsevier; 2017:549–79 pp.10.1016/B978-0-12-809286-6.00026-1Search in Google Scholar

92. Elleuch, M, Bedigian, D, Zitoun, A. Sesame (Sesamum indicum L.) seeds in food, nutrition, and health. Nuts and seeds in health and disease prevention. Academic Press; 2011:1029–36 p.10.1016/B978-0-12-375688-6.10122-7Search in Google Scholar

93. Ashamu, E, Salawu, E, Oyewo, O, Alhassan, A, Alamu, O, Adegoke, A. Efficacy of vitamin C and ethanolic extract of Sesamum indicum in promoting fertility in male Wistar rats. J Hum Reprod Sci 2010;3:11–4. https://doi.org/10.4103/0974-1208.63115.Search in Google Scholar PubMed PubMed Central

94. Abbasi, Z, Tabatabaei, SR, Mazaheri, Y, Barati, F, Morovvati, H. Effects of sesame oil on the reproductive parameters of diabetes mellitus-induced male rats. World J Mens Health 2013;31:141–9. https://doi.org/10.5534/wjmh.2013.31.2.141.Search in Google Scholar PubMed PubMed Central

95. Dada, AA. Dietary sesame improves reproductive performance of male African catfish. World Aquacult 2013;44:66–7.Search in Google Scholar

96. AL-Sallami, AS. Effect of sesame oil on male rats treated with acrylamide in some physiological and hormonal blood criteria. Int J Curr Pharm Rev Res 2017;8:134–40. https://doi.org/10.25258/ijcprr.v8i02.9197.Search in Google Scholar

97. Uno, UU-U, Ndifon, TB, Esua, IS, Ekaluo, UB. Ameliorating potential of sesame (Sesamum indicum L.) on caffeine induced sperm toxicity in male albino rats. Sciences 2019;12:204–9.10.3923/ajbs.2019.204.209Search in Google Scholar

98. Khaneshi, F, Nasrolahi, O, Azizi, S, Nejati, V. Sesame effects on testicular damage in streptozotocin-induced diabetes rats. Avicenna J Phytomed 2013;3:347.Search in Google Scholar

99. Sadeghi, E, Ghotbodin, Z. The effects of sesame seeds on the pituitary-gonadal axis in adult male rats. Urmia Med J 2016;27:580–8.Search in Google Scholar

100. Khani, B, Bidgoli, SR, Moattar, F, Hassani, H. Effect of sesame on sperm quality of infertile men. J Res Med Sci 2013;18:184–7.Search in Google Scholar

101. Abbasi, Z, Fatemi Tabatabaei, SR, Barati, F, Mazaheri, Y, Morovati, H. The effects of sesame oil on some reproductive parameters of male rats. Iran J Endocrinol Metab 2013;15:94–9.Search in Google Scholar

102. Cooney, RV, Custer, LJ, Okinaka, L, Franke, AA. Effects of dietary sesame seeds on plasma tocopherol levels. Nutr Cancer 2001;39:66–71. https://doi.org/10.1207/s15327914nc391_9.Search in Google Scholar PubMed

103. Rosso, B, Pagano, E. Evaluation of introduced and naturalised populations of red clover (Trifolium pratense L.) at Pergamino EEA-INTA, Argentina. Genet Resour Crop Evol 2005;52:507–11. https://doi.org/10.1007/s10722-005-0777-z.Search in Google Scholar

104. Ulkay, MB, Aktaş, A, Bozkurt, HH. The effect of Trifolium pratense L. (red clover) on rat testes. Kafkas Univ Vet Fak. 2008;14.Search in Google Scholar

105. Ghazanfarpour, M, Sadeghi, R, Roudsari, RL, Khorsand, I, Khadivzadeh, T, Muoio, B. Red clover for treatment of hot flashes and menopausal symptoms: a systematic review and meta-analysis. J Obstet Gynaecol 2016;36:301–11. https://doi.org/10.3109/01443615.2015.1049249.Search in Google Scholar PubMed

106. George, J, Turnbull, K. The effect of red clover pasture on the reproductive tract of ram lambs. Aust J Agric Res 1966;17:919–22. https://doi.org/10.1071/ar9660919.Search in Google Scholar

107. Bakirel, T, Keleş, O, Bozkurt, HH, Ak, K. The effect of Trifolium pratense on spermatogenesis and its acute toxicity (LD_ {50}) in mice. Turk J Vet Anim Sci 2002;26:555–9.Search in Google Scholar

108. Rochester, JR, Klasing, KC, Stevenson, L, Denison, MS, Berry, W, Millam, JR. Dietary red clover (Trifolium pratense) induces oviduct growth and decreases ovary and testes growth in Japanese quail chicks. Reprod Toxicol 2009;27:63–71. https://doi.org/10.1016/j.reprotox.2008.11.056.Search in Google Scholar PubMed PubMed Central

109. Srinivasan, K. Fenugreek (Trigonella foenum-graecum L.) seeds used as functional food supplements to derive diverse health benefits. Nonvitamin and nonmineral nutritional supplements. Academic press; 2019:217–21 p.10.1016/B978-0-12-812491-8.00031-XSearch in Google Scholar

110. Basu, TK, Srichamroen, A. Health benefits of fenugreek (Trigonella foenum-graecum leguminosse). Bioactive foods in promoting health. Academic press; 2010:425–35 p.10.1016/B978-0-12-374628-3.00028-1Search in Google Scholar

111. Shamshad Begum, S, Jayalakshmi, H, Vidyavathi, H, Gopakumar, G, Abin, I, Balu, M, et al.. A novel extract of fenugreek husk (FenuSMART™) alleviates postmenopausal symptoms and helps to establish the hormonal balance: a randomized, double‐blind, placebo‐controlled study. Phytother Res 2016;30:1775–84. https://doi.org/10.1002/ptr.5680.Search in Google Scholar PubMed

112. SA, S, Shalaby, S. Effect of fenugreek seed extract on carbofuran-inhibited spermatogenesis and induced apoptosis in albino rats. J Infertil Reprod Biol 2014;2:36–42.Search in Google Scholar

113. Lamfon, HA. Effect of fenugreek seed extract on carbendazim-inhibited spermatogenesis in albino rats. J Appl Pharm Sci 2012;2:9.10.7324/JAPS.2012.2423Search in Google Scholar

114. Kaur, S, Sadwal, S. Studies on the phytomodulatory potential of fenugreek (Trigonella foenum-graecum) on bisphenol – a induced testicular damage in mice. Andrologia 2020;52:e13492. https://doi.org/10.1111/and.13492.Search in Google Scholar PubMed

115. Taha, AT. Effcet of dietary supplementation with different levels of fenugreek seeds (Trigonella foenum graecum) on semen quality and histological testis traits of Japanese quail (Coturnix coturnix japonica). Diyala J Agric Sci 2011;3:1–9.Search in Google Scholar

116. Hind, B, Zineb, M, Elbachir, H, Najat, EA, Siham, A, Driss, R. Evaluation of potential effects of the aqueous extract of fenugreek seeds on fertility in male rats. J Ayu Herbal Med 2017;3:210–5.10.31254/jahm.2017.3408Search in Google Scholar

117. Kassem, A, Al-Aghbari, A, Molham, A-H, Al-Mamary, M. Evaluation of the potential antifertility effect of fenugreek seeds in male and female rabbits. Contraception 2006;73:301–6. https://doi.org/10.1016/j.contraception.2005.08.020.Search in Google Scholar PubMed

118. Kamal, R, Yadav, R, Sharma, J. Efficacy of the steroidal fraction of fenugreek seed extract on fertility of male albino rats. Phytother Res 1993;7:134–8. https://doi.org/10.1002/ptr.2650070208.Search in Google Scholar

119. Ibrahim, M, El-Tawill, G. Possible outcome of fenugreek seeds powder administration on the fertility of female and male albino rat. J Rad Res Appl Sci 2010;3:357–72.Search in Google Scholar

120. Al-khalisy, M. Treatment of men infertility using low doses of fenugreek oil extract. Adv Life Sci 2015;29:13–7.Search in Google Scholar

121. Rao, A, Steels, E, Inder, WJ, Abraham, S, Vitetta, L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study. Aging Male 2016;19:134–42. https://doi.org/10.3109/13685538.2015.1135323.Search in Google Scholar PubMed

122. Yang, J, Martinson, TE, Liu, RH. Phytochemical profiles and antioxidant activities of wine grapes. Food Chem 2009;116:332–9. https://doi.org/10.1016/j.foodchem.2009.02.021.Search in Google Scholar

123. USDA. National nutrient data base. Available from: https://fdc.nal.usda.gov/fdc-app.html#/food-details/174683/nutrients.Search in Google Scholar

124. Lamas, CA, Cuquetto-Leite, L, do Nascimento da Silva, E, Thomazini, BF, Cordeiro, GDS, Predes, FS, et al.. Grape juice concentrate alleviates epididymis and sperm damage in cadmium-intoxicated rats. Int J Exp Pathol 2017;98:86–99. https://doi.org/10.1111/iep.12227.Search in Google Scholar PubMed PubMed Central

125. Lamas, CA, Gollücke, AP, Dolder, H. Grape juice concentrate (G8000®) intake mitigates testicular morphological and ultrastructural damage following cadmium intoxication. Int J Exp Pathol 2015;96:301–10. https://doi.org/10.1111/iep.12141.Search in Google Scholar PubMed PubMed Central

126. Pires, VC, Gollücke, APB, Ribeiro, DA, Lungato, L, D’Almeida, V, Aguiar, O. Grape juice concentrate protects reproductive parameters of male rats against cadmium-induced damage: a chronic assay. Br J Nutr 2013;110:2020–9. https://doi.org/10.1017/s0007114513001360.Search in Google Scholar PubMed

127. Halder, S, Sarkar, M, Dey, S, Kumar Bhunia, S, Ranjan Koley, A, Giri, B. Protective effects of red grape (Vitis vinifera) juice through restoration of antioxidant defense, endocrine swing and Hsf1, Hsp72 levels in heat stress induced testicular dysregulation of Wister rat. J Therm Biol 2018;71:32–40. https://doi.org/10.1016/j.jtherbio.2017.10.011.Search in Google Scholar PubMed

128. Zhao, J, Jin, Y, Du, M, Liu, W, Ren, Y, Zhang, C, et al.. The effect of dietary grape pomace supplementation on epididymal sperm quality and testicular antioxidant ability in ram lambs. Theriogenology 2017;97:50–6. https://doi.org/10.1016/j.theriogenology.2017.04.010.Search in Google Scholar PubMed

129. Eid, Y. Dietary grape pomace affects lipid peroxidation and antioxidative status in rabbit semen. World Rabbit Sci 2008;16:157–64.10.4995/wrs.2008.624Search in Google Scholar

130. Gloria, A, Contri, A, Grotta, L, Carluccio, A, Robbe, D, Ianni, A, et al.. Effect of dietary grape marc on fresh and refrigerated boar semen. Anim Reprod Sci 2019;205:18–26. https://doi.org/10.1016/j.anireprosci.2019.03.016.Search in Google Scholar PubMed

131. Sapanidou, VG, Margaritis, I, Siahos, N, Arsenopoulos, K, Dragatidou, E, Taitzoglou, IA, et al.. Antioxidant effect of a polyphenol-rich grape pomace extract on motility, viability and lipid peroxidation of thawed bovine spermatozoa. J Biol Res 2014;21:19. https://doi.org/10.1186/2241-5793-21-19.Search in Google Scholar PubMed PubMed Central

132. Juan, ME, Gonzalez-Pons, E, Munuera, T, Ballester, J, Rodriguez-Gil, JE, Planas, JM. trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J Nutr 2005;135:757–60. https://doi.org/10.1093/jn/135.4.757.Search in Google Scholar PubMed

133. Afzalzadeh, MR, Ahangarpour, A, Amirzargar, A, Varnamkhasti, MK, Ganjalidarani, H. The effect of Vitis vinifera L. juice on serum levels of Inhibin B, sperm count in adult male rats. World J Mens Health 2015;33:109–16. https://doi.org/10.5534/wjmh.2015.33.2.109.Search in Google Scholar PubMed PubMed Central

134. Ghalehkandi, JG, Hassanpour, S, Issabeagloo, E, Asghari, A. Assessment of the effects of red onion (Allium cepa Linn.) juice on semen oxidative status compared to Zn sulfate in rats. Anim Reprod 2018;12:298–304.Search in Google Scholar

135. Khaki, A, Fathiazad, F, Nouri, M, Khaki, AA, Khamenehi, HJ, Hamadeh, M. Evaluation of androgenic activity of allium cepa on spermatogenesis in the rat. Folia Morphol 2009;68:45–51.Search in Google Scholar

136. Hosseini, N, Khaki, A. Effect of aqueous extract of garlic (Allium sativum) on sperms morphology, motility, concentration and its antioxidant activity in rats. Afinidad 2014;80:201–4.Search in Google Scholar

137. Hajiuon, B. Effects of garlic (Allium sativum L.) hydroalcoholic extract on estrogen, progesterone and testosterone levels in rats exposed to cell phone radiation. Zahedan J Res Med Sci 2014;16:20–5.Search in Google Scholar

138. Coffua, LS, Martin-DeLeon, PA. Effectiveness of a walnut-enriched diet on murine sperm: involvement of reduced peroxidative damage. Heliyon 2017;3:e00250. https://doi.org/10.1016/j.heliyon.2017.e00250.Search in Google Scholar PubMed PubMed Central

139. Bostani, M, Aqababa, H, Hosseini, SE, Ashtiyani, SC. A study on the effects of walnut oil on plasma levels of testosterone pre and post puberty in male rats. Am J Ethnomed 2014;1:266–75.Search in Google Scholar

140. Dokhanchi, M, Jashni, HK, Tanideh, N, Azarpira, N. Effects of heart of palm (Palmito) extract on reproductive system of adult male rats. Asian Pac J Reprod2013;2:272–6. https://doi.org/10.1016/s2305-0500(13)60161-x.Search in Google Scholar

141. Tomilola Debby, O, Appenroth, K, Singh, R, Gautam, N, Mishra, A, Gupta, R, et al.. Protective effect of date palm extracts on cadmium-induced infertility in male rats. Res J Obstet Gynecol 2010;11:19–29.Search in Google Scholar

142. Iftikhar, S, Bashir, A, Anwar, MS, Mastoi, SM, Shahzad, M. Effect of date palm pollen (dpp) on serum testosterone levels in prepubertal albino rats. Pak J Med Health Sci 2011;6:639–44.Search in Google Scholar

143. Bahmanpour, S, PANJEH, SM, Talaei, T, Vojdani, Z, POUST, PA, Zareei, S, et al.. Effect of Phoenix dactylifera pollen on sperm parameters and reproductive system of adult male rats. Iran J Med Sci 2006;31:208–212.Search in Google Scholar

144. Khodaei-Motlagh, M, Zhandi, M, Kazemi-Bonchenari, M, Moradi, M, Mohamadi, A. Sperm quality parameters and fatty acid composition in Farahani rams fed pistachio by-products. J Livest Sci Technol 2019;7:39–44.Search in Google Scholar

145. Mahabadi, JA, Bafrani, HH, Nikzad, H. Effect of sesame-supplemented diet on prostate and seminal vesicle histology of adult rat. Int J Morphol 2016;34. https://doi.org/10.4067/s0717-95022016000200030.Search in Google Scholar

146. Amini Mahabadi, J, Hassani Bafrani, H, Nikzad, H, Taherian, A, Salehi, M. Effect of diet contains sesame seed on adult Wistar rat testis. Int J Morphol 2013;31:197–202. https://doi.org/10.4067/s0717-95022013000100033.Search in Google Scholar

147. Nikaein, F, Zargaran, A, Mehdizadeh, A. Rhazes’ concepts and manuscripts on nutrition in treatment and health care. Ancient Sci Life 2012;31:160.10.4103/0257-7941.107357Search in Google Scholar PubMed PubMed Central

148. Alibeigi, Z, Jafari-Dehkordi, E, Kheiri, S, Nemati, M, Mohammadi-Farsani, G, Tansaz, M. The impact of traditional medicine-based lifestyle and diet on infertility treatment in women undergoing assisted reproduction: a randomized controlled trial. Complementary Med Res 2020:1–12. https://doi.org/10.1159/000505016.Search in Google Scholar PubMed

149. Henkel, R, Sandhu, IS, Agarwal, A. The excessive use of antioxidant therapy: a possible cause of male infertility? Andrologia 2019;51:e13162. https://doi.org/10.1111/and.13162.Search in Google Scholar PubMed

150. Mendiola, J, Torres-Cantero, AM, Vioque, J, Moreno-Grau, JM, Ten, J, Roca, M, et al.. A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertil Steril 2010;93:1128–33. https://doi.org/10.1016/j.fertnstert.2008.10.075.Search in Google Scholar PubMed

151. Bahmanpour, S, Kavoosi, F, Talaei, T, Panjehshahin, MR. Effects of date palm (Phoenix dactylifera) gemmule extract on morphometric parameters of reproductive tissues, hormones and sperm quality in rat. Anat Sci J 2013;10:144–50.Search in Google Scholar

Received: 2020-08-02
Accepted: 2021-01-02
Published Online: 2021-02-03

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 2.12.2023 from https://www.degruyter.com/document/doi/10.1515/jcim-2020-0254/html
Scroll to top button