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Licensed Unlicensed Requires Authentication Published by De Gruyter May 10, 2021

Herbal supplement (Combi-5) in the management of COVID 19 individual with mild to moderate symptoms: a case report

  • Augustine Anayochukwu Onyeaghala ORCID logo EMAIL logo , Emmanuella Ogechi Onyeaghala , Chinedum Peace Babalola ORCID logo , Oluwasanmi Olayinka Aina and Dadik Jelpe



To explore repurposing known natural products for managing patients with mild to moderate symptoms of COVID-19.

Case presentation

We present a case report of a middle aged woman, who was positive to COVID 19, with mild to moderate symptoms; who self –managed at home using well formulated herbal supplement (Combi-5) taken along with vitamin C and Zinc supplements. She recovered within a short time.


While we may not conclude from this report that Combi-5 was solely responsible for the recovery of the patient, we strongly believe that it played significant role through different mechanisms in facilitating early recovery from the infection. Further studies are needed to evaluate the phytochemical and pharmacological constituents of the supplement; investigate its direct effect(s) on SARS CoV-2 and conduct randomized controlled trial to elucidate its clinical benefits.

Corresponding author: Dr. Augustine Anayochukwu Onyeaghala, Unit of Clinical Chemistry, Department of Medical Laboratory Science, University College Hospital, Ibadan, Nigeria; and Unit of Clinical Chemistry, Department of Medical Laboratory Science, Lead City University, Ibadan, Nigeria, E-mail:


We thank the patient who volunteered to take the herbal supplement and for giving her consent to document this report.

  1. Research funding: Nil.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Nil.


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Received: 2020-10-15
Accepted: 2020-11-16
Published Online: 2021-05-10

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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