St. John’s wort (Hypericum perforatum) has been used in traditional medicine for centuries for different conditions, including kidney and lung ailments, insomnia, depression, and to aid wound healing. The objective of the present bibliometric analysis is to capture the characteristics of research publications on the topic of St. John’s wort.
Searches were run on April 09, 2021, and results were exported on the same day to prevent discrepancies between daily database updates. Trends associated with this subset of publications were identified and presented. Bibliometric networks were constructed and visualized using the software tool VOSviewer.
A total of 1,970 publications were published by 5,849 authors across 961 journals from 1859 to 2021. Beginning in the late 1990s, a steep increase was found in the volume of publication on this topic. The journal that published the largest number of publications was Phytotherapy Research. The most productive countries included Germany and the United States.
The present study provides the characteristics of the St. John’s wort literature that allows understanding of the past, present, and future of research in this area. It is a useful evidence-based framework on which to base future research actions and academic directions.
Funding source: McMaster University
JYN was awarded a Research Scholarship and an Entrance Scholarship from the Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences at McMaster University.
Research funding: None declared.
Author contributions: JYN: designed and conceptualized the study, collected and analysed data, drafted the manuscript, and gave final approval of the version to be published.
Competing interests: The author declares that they have no competing interests.
Ethics approval: This study involved a bibliometric analysis of the literature only; it did not require ethics approval or consent to participate.
1. Centre for Agriculture and Bioscience International. Invasive Species Compendium [Internet]. Hypericum perforatum (St. John’s wort); 2015. Available from: https://www.cabi.org/isc/datasheet/28268 [Accessed 10 Apr 2021].Search in Google Scholar
2. National Center for Complementary and Integrative Health (NCCIH) [Internet]. St. John’s Wort; 2020. Available from: https://www.nccih.nih.gov/health/st-johns-wort [Accessed 10 Apr 2021].Search in Google Scholar
3. Miller, AL. St. John’s wort (Hypericum perforatum): clinical effects on depression and other conditions. Alternative Med Rev J Clin Therapeut 1998;3:18–26.Search in Google Scholar
4. Zobayed, SS, Saxena, PK. Production of St. John’s wort plants under controlled environment for maximizing biomass and secondary metabolites. In Vitro Cell Dev Biol Plant 2004;40:108–14. https://doi.org/10.1079/ivp2003498.Search in Google Scholar
5. Scotti, F, Löbel, K, Booker, A, Heinrich, M. St. John’s wort (Hypericum perforatum) products – How variable is the primary material? Front Plant Sci 2019;9:1973. https://doi.org/10.3389/fpls.2018.01973.Search in Google Scholar PubMed PubMed Central
6. German Society for Psychiatry, Psychotherapy, and Neurology (DGPPN). Guideline Group Unipolar Depression*. S3‐Guideline/National Disease Management Guideline Unipolar Depression. Short Version. Dusseldorf: Berlin; 2009. Available from: https://www.aezq.de/mdb/downloads/nvl/depression/archiv/unipolare-depression-kurz-engl-1.3.pdf.Search in Google Scholar
7. Dörks, M, Langner, I, Dittmann, U, Timmer, A, Garbe, E. Antidepressant drug use and off-label prescribing in children and adolescents in Germany: results from a large population-based cohort study. Eur Child Adolesc Psychiatry 2013;22:511–8. https://doi.org/10.1007/s00787-013-0395-9.Search in Google Scholar PubMed
8. Forsdike, K, Pirotta, M. St. John’s wort for depression: scoping review about perceptions and use by general practitioners in clinical practice. J Pharm Pharmacol 2019;71:117–28. https://doi.org/10.1111/jphp.12775.Search in Google Scholar PubMed
9. Linde, K, Berner, MM, Kriston, L. St. John’s wort for major depression. Cochrane Database Syst Rev 2008. Art. No.: CD000448. https://doi.org/10.1002/14651858.cd000448.pub3.Search in Google Scholar PubMed PubMed Central
10. Canning, S, Waterman, M, Orsi, N, Ayres, J, Simpson, N, Dye, L. The efficacy of Hypericum perforatum (St. John’s wort) for the treatment of premenstrual syndrome. CNS Drugs 2010;24:207–25. https://doi.org/10.2165/11530120-000000000-00000.Search in Google Scholar PubMed
11. Kobak, KA, Taylor, LV, Bystritsky, A, Kohlenberg, CJ, Greist, JH, Tucker, P, et al.. St. John’s wort versus placebo in obsessive – compulsive disorder: results from a double-blind study. Int Clin Psychopharmacol 2005;20:299–304. https://doi.org/10.1097/00004850-200511000-00003.Search in Google Scholar PubMed
13. Klemow, KM, Bartlow, A, Crawford, J, Kocher, N, Shah, J, Ritsick, M. Medical attributes of St. John’s Wort (Hypericum perforatum). In: Benzie IFF, Wachtel-Galor S, editors. Herbal medicine: biomolecular and clinical aspects, 2nd ed. Boca Raton, FL: CRC Press/Taylor & Francis; 2011. Chapter 11. Available from. https://www.ncbi.nlm.nih.gov/books/NBK92750/.10.1201/b10787-12Search in Google Scholar
14. Silvana, L, Mahoney, MC. St. John’s wort. Am. Fam. Phys. 2005;72:2249–54.Search in Google Scholar
15. Galeotti, N. Hypericum perforatum (St. John’s wort) beyond depression: a therapeutic perspective for pain conditions. J Ethnopharmacol 2017;200:136–46. https://doi.org/10.1016/j.jep.2017.02.016.Search in Google Scholar PubMed
16. Ernst, E, Rand, JI, Barnes, J, Stevinson, C. Adverse effects profile of the herbal antidepressant St. John’s wort (Hypericum perforatum L.). Eur J Clin Pharmacol 1998;54:589–94. https://doi.org/10.1007/s002280050519.Search in Google Scholar PubMed
17. Maher, AR, Hempel, S, Apaydin, E, Shanman, RM, Booth, M, Miles, JN, et al.. St. John’s wort for major depressive disorder: a systematic review. Rand Health Quart 2016;5:1–25. https://doi.org/10.1186/s13643-016-0325-2.Search in Google Scholar PubMed PubMed Central
18. Tanaka, E. Clinically significant pharmacokinetic drug interactions with benzodiazepines. J Clin Pharm Therapeut 1999;24:347–55. https://doi.org/10.1046/j.1365-2710.1999.00247.x.Search in Google Scholar PubMed
19. Gurley, BJ, Swain, A, Williams, DK, Barone, G, Battu, SK. Gauging the clinical significance of P‐glycoprotein‐mediated herb‐drug interactions: comparative effects of St. John’s wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics. Mol Nutr Food Res 2008;52:772–9. https://doi.org/10.1002/mnfr.200700081.Search in Google Scholar PubMed PubMed Central
20. Henderson, L, Yue, QY, Bergquist, C, Gerden, B, Arlett, P. St. John’s wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol 2002;54:349–56. https://doi.org/10.1046/j.1365-2125.2002.01683.x.Search in Google Scholar PubMed PubMed Central
22. Madabushi, R, Frank, B, Drewelow, B, Derendorf, H, Butterweck, V. Hyperforin in St. John’s wort drug interactions. Eur J Clin Pharmacol 2006;62:225–33. https://doi.org/10.1007/s00228-006-0096-0.Search in Google Scholar PubMed
23. Gordon, JB. SSRIs and St. John’s wort: possible toxicity? Am Family Phys 1998;57:950.Search in Google Scholar
24. Lantz, MS, Buchalter, E, Giambanco, V. St. John’s wort and antidepressant drug interactions in the elderly. J Geriatr Psychiatry Neurol 1999;12:7–10. https://doi.org/10.1177/089198879901200103.Search in Google Scholar PubMed
25. Pfrunder, A, Schiesser, M, Gerber, S, Haschke, M, Bitzer, J, Drewe, J. Interaction of St. John’s wort with low‐dose oral contraceptive therapy: a randomized controlled trial. Br J Clin Pharmacol 2003;56:683–90. https://doi.org/10.1046/j.1365-2125.2003.02005.x.Search in Google Scholar PubMed PubMed Central
26. Murphy, PA, Kern, SE, Stanczyk, FZ, Westhoff, CL. Interaction of St. John’s wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. Contraception 2005;71:402–8. https://doi.org/10.1016/j.contraception.2004.11.004.Search in Google Scholar PubMed
27. Pritchard, A. Statistical bibliography or bibliometrics. J Doc 1969;25:348–9.Search in Google Scholar
29. Hicks, D, Wouters, P, Waltman, L, De Rijcke, S, Rafols, I. Bibliometrics: the Leiden Manifesto for research metrics. Nat News 2015;520:429. https://doi.org/10.1038/520429a.Search in Google Scholar PubMed
30. St. John’s Wort. Natural Medicines [database on the Internet]. Somerville (MA): Therapeutic Research Center; 2021. Available from: https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=329 [Accessed 10 Apr 2021]. Subscription required to view.Search in Google Scholar
32. Gusenbauer, M, Haddaway, NR. Which academic search systems are suitable for systematic reviews or meta‐analyses? Evaluating retrieval qualities of Google Scholar, PubMed, and 26 other resources. Res Synth Methods 2020;11:181–217. https://doi.org/10.1002/jrsm.1378.Search in Google Scholar PubMed PubMed Central
34. Van Eck, NJ, Waltman, L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 2010;84:523–38. https://doi.org/10.1007/s11192-009-0146-3.Search in Google Scholar PubMed PubMed Central
36. Ekor, M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014;4:177. https://doi.org/10.3389/fphar.2013.00177.Search in Google Scholar PubMed PubMed Central
37. Garcia-Garcia, P, Lopez-Munoz, F, Rubio, G, Martin-Agueda, B, Alamo, C. Phytotherapy and psychiatry: bibliometric study of the scientific literature from the last 20 years. Phytomedicine 2008;15:566–76. https://doi.org/10.1016/j.phymed.2008.04.014.Search in Google Scholar PubMed
38. Salmerón-Manzano, E, Garrido-Cardenas, JA, Manzano-Agugliaro, F. Worldwide research trends on medicinal plants. Int J Environ Res Public Health 2020;17:3376.10.3390/ijerph17103376Search in Google Scholar PubMed PubMed Central
39. Yeung, AW, Mocan, A, Atanasov, AG. Let food be thy medicine and medicine be thy food: a bibliometric analysis of the most cited papers focusing on nutraceuticals and functional foods. Food Chem 2018;269:455–65. https://doi.org/10.1016/j.foodchem.2018.06.139.Search in Google Scholar PubMed
40. Yeung, AW, Heinrich, M, Atanasov, AG. Ethnopharmacology—a bibliometric analysis of a field of research meandering between medicine and food science? Front Pharmacol 2018;9:215. https://doi.org/10.3389/fphar.2018.00215.Search in Google Scholar PubMed PubMed Central
41. Dauncey, EA, Irving, JT, Allkin, R. A review of issues of nomenclature and taxonomy of Hypericum perforatum L. and Kew’s Medicinal Plant Names Services. J Pharm Pharmacol 2019;71:4–14. https://doi.org/10.1111/jphp.12831.Search in Google Scholar PubMed PubMed Central
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