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The effect of Salvia officinalis on blood glycemic indexes and blood lipid profile in diabetic patients: a systematic review and meta-analysis

  • Ali Abdollahi , Faeze Adelibahram , Nafiseh Ghassab-Abdollahi , Mostafa Araj-khodaei , Zahra Parsian and Mojgan Mirghafourvand EMAIL logo


Diabetes is one of the most common endocrine disorders that increases the economic burden on the public health system. In this regard, understanding the effect of available herbs on diabetes can be useful. This systematic review was performed to determine the effect of Salvia officinalis on blood glycemic indexes and blood lipid profile (primary outcomes) and 2 h postprandial blood glucose (2HPPG), alanine transaminase (ALT) (U/L) and aspartate transaminase (AST) (U/L) and its side effects (secondary outcomes) in diabetic patients. A systematic search was conducted in the English (Cochrane Library, Medline (PubMed), Scopus, CINAHL, ProQuest and Persian databases since inception to March 2021, without publication time restriction. Two authors separately evaluated the quality of the articles using Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials and extracted the data. Heterogeneity of data was evaluated by squared I (I2). Three studies included in the review and all of them included in meta-analysis. The results of meta-analysis showed that S. officinalis reduced fasting blood sugar (FBS) (mg/dL) (MD: −31.15; 95% CI: −37.56 to −24.73; p<0.00001). It also reduced HbA1c (%) (MD: −0.94; 95% CI: −1.25 to −0.63; p<0.00001) and total cholesterol (mg/dL) (MD: −43.64; 95% CI: −83.26 to −4.02; p=0.03) and reduction of low-density protein (LDL) (mg/dL) (MD: −19.23; 95% CI: −35.81 to −2.65; p=0.02) but it did not have a significant effect on triglyceride (mg/dL) (p=0.09), and high-density lipoprotein (HDL) (mg/dL) (p=0.18). Regarding the secondary outcomes, S. officinalis also had significant effect on 2HPPG, but it did not have a significant effect on ALT (U/L) and AST (U/L). No specific side effects for this plant were reported in these three studies. The results showed that S. officinalis has a positive effect on blood glycemic status and blood lipid profile in diabetes except for triglyceride and HDL. However, due to the small number of included articles, it is recommended that stronger clinical trials be conducted in this field.

Corresponding author: Mojgan Mirghafourvand, Social Determinants of Health Research Center, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran, E-mail:

Award Identifier / Grant number: 65126


Hereby, we thank all of the authors and researchers of the surveys that are used in this article and we would like to thank Student Research Committee, Tabriz University of Medical Sciences for their support.

  1. Research funding: This research was funded by Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran (Grant No. 65126).

  2. Author contribution: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


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Supplementary Material

The online version of this article offers supplementary material (

Received: 2021-09-14
Revised: 2021-12-09
Accepted: 2022-01-05
Published Online: 2022-01-25

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