Skip to content
BY-NC-ND 3.0 license Open Access Published by De Gruyter March 9, 2018

SBML Level 3 Package: Flux Balance Constraints version 2

Brett G. Olivier ORCID logo EMAIL logo and Frank T. Bergmann ORCID logo


Constraint-based modeling is a well established modeling methodology used to analyze and study biological networks on both a medium and genome scale. Due to their large size and complexity such steady-state flux models are, typically, analyzed using constraint-based optimization techniques, for example, flux balance analysis (FBA). The Flux balance constraints (FBC) Package extends SBML Level 3 and provides a standardized format for the encoding, exchange and annotation of constraint-based models. It includes support for modeling concepts such as objective functions, flux bounds and model component annotation that facilitates reaction balancing. Version two expands on the original release by adding official support for encoding gene-protein associations and their associated elements. In addition to providing the elements necessary to unambiguously encode existing constraint-based models, the FBC Package provides an open platform facilitating the continued, cross-community development of an interoperable, constraint-based model encoding format.

Received: 2017-12-21
Accepted: 2018-2-8
Published Online: 2018-3-9

©2018 Brett G. Olivier et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Downloaded on 29.1.2023 from
Scroll Up Arrow