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Licensed Unlicensed Requires Authentication Published by De Gruyter July 28, 2012

A method to determine the likelihood of transition to puberty in a heterogeneous prepubertal age group

James Frane, George M. Bright and Peter A. Lee

Abstract

A model based on pubertal status and age in normal healthy children that can be used to estimate the probability that a given child will enter or progress through puberty in a given period is presented. This model could also be used to estimate the proportion of children who would be expected to have changes in their pubertal status over a given period, for example, in an interventional trial of growth promoting agents.


Corresponding author: Peter A. Lee, Penn State College of Medicine, The Milton S. Hershey Medical Center, PO Box 850, Hershey, PA 17033-0850, USA

Received: 2012-4-10
Accepted: 2012-6-25
Published Online: 2012-07-28
Published in Print: 2012-10-01

©2012 by Walter de Gruyter Berlin Boston