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Licensed Unlicensed Requires Authentication Published by De Gruyter July 5, 2012

Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents

  • Ioanna Partsalaki, , Alexia Karvela and Bessie E. Spiliotis EMAIL logo


Background: The effects of carbohydrate-restricted (ketogenic) diets on metabolic parameters in children have been incompletely assessed.

Objective: To compare the efficacy and metabolic impact of ketogenic and hypocaloric diets in obese children and adolescents.

Subjects: Fifty-eight obese subjects were placed on one of the two diets for 6 months.

Methods: Anthropometric measurements, body composition, oral glucose/insulin tolerance test, lipidemic profile, high molecular weight (HMW) adiponectin, whole-body insulin sensitivity index (WBISI), and homeostatic model assessment-insulin resistance (HOMA-IR) were determined before and after each diet.

Results: Both groups significantly reduced their weight, fat mass, waist circumference, fasting insulin, and HOMA-IR (p=0.009 for ketogenic and p=0.014 for hypocaloric), but the differences were greater in the ketogenic group. Both groups increased WBISI significantly, but only the ketogenic group increased HMW adiponectin significantly (p=0.025).

Conclusions: The ketogenic diet revealed more pronounced improvements in weight loss and metabolic parameters than the hypocaloric diet and may be a feasible and safe alternative for children’s weight loss.

Corresponding author: Bessie E. Spiliotis, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Patras School of Medicine, Patras, Achaea, Greece Phone: +30-2613-603-741, Fax: +30-2610-994-533

Received: 2012-4-24
Accepted: 2012-5-27
Published Online: 2012-07-05
Published in Print: 2012-08-01

©2012 by Walter de Gruyter Berlin Boston

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