Accessible Unlicensed Requires Authentication Published by De Gruyter August 10, 2013

Hypothalamic hamartoma associated with central precocious puberty and growth hormone deficiency

Isabelle Rousseau-Nepton, Sagi Kaduri, Natasha Garfield and Preetha Krishnamoorthy


Hypothalamic hamartomas (HHs) are tumors generally associated with isolated central precocious puberty (CPP). To our knowledge, we report a unique case of a girl with HH associated with CPP and growth hormone deficiency. This case highlights the complex interaction between HHs and the hypothalamic-pituitary-gonadal axis. It also emphasizes the value of close follow-up of growth velocity in these patients even after treatment of the CPP.

Corresponding author: Isabelle Rousseau-Nepton, MD, Department of Endocrinology and Metabolism, Montreal Children’s Hospital, 2300, Tupper Street, Room E315, Montreal, Quebec, H3H1P3, Canada, Phone: +1-514-412-4400 ext. 22250, E-mail:

We gratefully acknowledge Dr. Christine St-Martin for her contribution to the interpretation of the MRI.

Conflict of interests statement

Funding source: No external funding was secured for this study.

Financial disclosure: The authors have no financial relationships relevant to this article to disclose.

Conflict of interests: The authors have no conflict of interests to disclose.

Authors’ contributions: Rousseau-Nepton drafted the initial manuscript and approved the final manuscript as submitted. Kaduri reviewed and revised the manuscript, contributed to the writing of the discussion and approved the final manuscript as submitted. Garfield critically reviewed the manuscript and approved the final manuscript as submitted. Krishnamoorthy critically reviewed the manuscript and approved the final manuscript as submitted.


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Received: 2013-3-18
Accepted: 2013-6-18
Published Online: 2013-08-10
Published in Print: 2014-01-01

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