Accessible Requires Authentication Published by De Gruyter February 21, 2015

Assessment of human cartilage glycoprotein 39 (YKL-40), preptin, and nitric oxide in adolescent patients with type 1 diabetes and its relation to cardiorenal affection

Soha M. Abd El Dayem, Ahmed A. Battah, Amal El Shehaby and Nagwa Abd Allah


Aim: To evaluate new biomarkers such as YKL-40, preptin, and nitric oxide (NO) in patients with diabetes and to assess its relation to cardiorenal injury.

Patients and methods: The study included 62 patients with type 1 diabetes and 30 healthy volunteers. Blood sample was taken for assessment of glycosylated hemoglobin, lipid profile, YKL-40, preptin, and NO. Also, urine sample was taken for analysis of albumin/creatinine ratio. Echocardiography was also done.

Results: NO was lower, whereas YKL-40, preptin, and albumin/creatinine ratio were significantly higher in patients with diabetes. NO had a significant negative correlation with LVEDD, LVESD, PWT, LV mass, YKL-40, preptin, and albumin/creatinine ratio. YKL-40 had a significant positive correlation with waist/height ratio, preptin and negative correlation with E/A ratio. Stepwise multiple regression revealed that E/A ratio is the only parameter related to YKL-40. On the contrary, NO and systolic blood pressure are related to preptin.

Conclusion: A significant reduction of NO and elevation of YKL-40 and preptin was found in patients with diabetes. A decrease in NO is associated with diastolic dysfunction, LV hypertrophy, and renal impairment, whereas YKL-40 is associated with diastolic dysfunction. An increase in preptin level was associated with hypertension.

Corresponding author: Soha M. Abd El Dayem, Professor of Pediatrics, Consultant of Diabetes and Endocrinology, Medical Research Division, Pediatrics Department, National Research Centre, Cairo, Egypt, Phone: +2 0106716852, Fax: +337093, E-mail:


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Received: 2014-8-24
Accepted: 2015-1-8
Published Online: 2015-2-21
Published in Print: 2015-3-1

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