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Licensed Unlicensed Requires Authentication Published by De Gruyter July 16, 2015

Kocher-Debré-Semelaigne syndrome with rhabdomyolysis and increased creatinine

  • Emine Ayça Cimbek EMAIL logo , Yaşar Şen , Sevil Arı Yuca , Demet Çam , Celal Gür and Harun Peru

Abstract

Association of Kocher-Debré-Semelaigne syndrome–a myopathy of hypothyroidism in childhood characterized by muscular hypertrophy, with rhabdomyolysis is very rare. We present a case of Kocher-Debré-Semelaigne syndrome with rhabdomyolysis secondary to Hashimoto’s thyroiditis. He had muscular symptoms simulating poly/dermatomyositis, massively elevated creatine kinase (CK) levels and high creatinine levels. All of the findings reversed on treatment of hypothyroidism. The response to the therapy strongly suggested that Kocher-Debré-Semelaigne (KDS) syndrome was the underlying etiology. Serum thyroid- stimulating hormone levels should be routinely determined in all patients with muscular symptoms and/or elevation of CK and creatinine, keeping KDS syndrome in mind.


Corresponding author: Emine Ayça Cimbek, MD, Division of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey, Phone: +90 332 22 43 998, E-mail:

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Received: 2014-10-3
Accepted: 2015-5-14
Published Online: 2015-7-16
Published in Print: 2015-11-1

©2015 by De Gruyter

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