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Licensed Unlicensed Requires Authentication Published by De Gruyter November 13, 2015

Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy

Linda Aurpibul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Virat Sirisanthana, Wanatpreeya Phongsamart, Tavitiya Sudjaritruk and Kulkanya Chokephaibulkit

Abstract

Background: Low vitamin D level is associated with adverse health outcomes and compromises HIV treatment response. We assess vitamin D status in HIV-infected Thai children receiving combination antiretroviral therapy (cART).

Methods: A cross-sectional study in perinatally HIV-infected children. Vitamin D deficiency and vitamin D insufficiency were defined as serum 25-hydroxyvitamin D (25-OHD) level <20, and 21–29 ng/mL, respectively.

Results: Eighty participants were enrolled. Their median age was 12.2 years. The median CD4 lymphocyte count was 784 cell/mm3; 95% had HIV RNA <50 copies/mL. The median (interquartile range, IQR) 25-OHD level was 33.5 (26.2–39.8) ng/mL. Thirty-four (43%) participants had low vitamin D level; 26 (33%) and 8 (10%) had vitamin D insufficiency and deficiency, respectively. In multivariate analysis, only geographic location was significantly associated with low vitamin D level.

Conclusions: Most of perinatally HIV-infected children receiving cART had low vitamin D level. Calcium and vitamin D supplement might be beneficial.


Corresponding author: Kulkanya Chokephaibulkit, MD, Faculty of Medicine Siriraj Hospital, Department of Pediatrics, Mahidol University, Bangkok, Thailand, Phone: +66-2418-0544

Acknowledgments

The authors gratefully acknowledge the participation of children and their families, as well as contributions of all study staff at both sites.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2015-5-15
Accepted: 2015-9-18
Published Online: 2015-11-13
Published in Print: 2016-4-1

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