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Licensed Unlicensed Requires Authentication Published by De Gruyter December 17, 2015

An adolescent girl referred with Cushing syndrome – does she or does she not have the syndrome?

  • Kung-Ting Kao EMAIL logo and Margaret Zacharin


Cushing syndrome and lipodystrophy syndromes share similar clinical features. This report describes an adolescent girl with newly diagnosed familial partial lipodystrophy type 2 (FPLD2) who was initially referred for Cushing syndrome. The type of abnormal fat deposition syndrome can be elucidated by careful clinical examination. FPLD2 can lead to type 2 diabetes mellitus and early cardiovascular events. Partial lipodystrophy presenting for the first time in adolescence can be mistaken for corticosteroid excess. Early diagnosis and preventative management of cardiovascular risk factors are crucial.

Corresponding author: Dr. Kung-Ting Kao, MBChB, Department of Endocrinology and Diabetes, Royal Children’s Hospital, Flemington Road, Parkville, Victoria 3052, Australia, Phone: + 61 3 9345 5951, Fax: + 61 3 9345 6240, E-mail: ; Murdoch Children’s Research Institute, Melbourne, Victoria, Australia; and University of Melbourne, Victoria, Australia


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Received: 2015-6-10
Accepted: 2015-7-6
Published Online: 2015-12-17
Published in Print: 2016-1-1

©2016 by De Gruyter

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